Enantiomer self‐disproportionation and chiral stationary phase based selective chiral separation of organic compounds

Abstract

In modern chromatography, chiral stationary phase (CSP) and enantiomer selfdisproportionation (ESD) are new inventions of packing material offer a guarantee for a successful enantiomeric separation. All CSPs were synthesized by chemical bonding of the relevant organic moieties onto a porous parent silica material for the separation of various racemic mixtures whereas achiral silica matrix was used for separation of non-racemic mixtures in ESD. Our present study provides to establish an understanding on the entire enantio-selective profile of amino alcohol based CSP as well as ESD and their precise utilization for high success rates for selective enantiomer separation with its appropriateness. Chirality 23:300-306, 2011. V V C 2010 Wiley-Liss, Inc.

Resolution of enantiomers with both achiral phases in chromatography: conceptual challenge

“…The sporadic reports till 1992 on such separations by liquid chromatography with both achiral phases were presented as a short review by Martens and Bhushan. 2 Since then there appeared a few more reports on enantioresolution of certain non racemic mixtures in achiral environment, these included some antihistamines, 3 binaphthol, 4,5 certain heterocyclic compounds 6 mandelic acid, 7,8 different uoro derivatives [9][10][11] and amine derivatives. 12 Martens and Bhushan 13 addressed the basic question and the concept 'why separation of one particular enantiomer (i.e., enantiomeric enrichment) should take place under achiral phase chromatography from the non-racemic mixture', discussed briey the technical terms used in literature and application of scientic terminology in the bounds of IUPAC while focusing on overlooked errors and scientic basis of separation in achiral environment during purication of enantiomeric mixtures in enantioselective synthesis.…”

Novel layered crystalline organic polymer-inorganic hybrid material comprising calcium phosphate with unique architectures for superior performance catalyst support

“…[27][28][29][30] However, the confinement effects have not been understood. This work could provide some fundamental insights.…”

“…As is known, the confinement effect of nanopores can contribute to a superior catalytic behavior from catalyst confined in nanopores. [27][28][29][30] However, the confinement effects have not been understood. This work could provide some fundamental insights.…”

Enantioseparations in Achiral Environments and Chromatographic Systems

“…(xiii) Enrichment of ( R )‐(−)‐mandelic acid with 28 % ee to 89.8 % ee using mesoporous silica M41S column (ground and sieved using 170 mesh size test sieves);, and…”