Abstract:An electrophilic enantioselective catalytic method for the a-pentafluoroethylation
of alkyl 1-indanone-2-carboxylates is
described. Under the use of La(OTf)<sub>3</sub> in combination with (<i>S,R</i>)-indanyl-<i>pybox</i> ligand good
results in terms of yield and enantioselectivities were achieved (up to 89% <i>ee</i>).
The reaction proceeds under mild conditions leading to the formation of
enantioenriched quaternary centers. This methodology uses an hypervalent… Show more
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