Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition

Abstract

An efficient strategy has been established for the enantiodivergent synthesis of natural product inspired compounds embodying both tropane and pyrrolidine natural product fragments.T his strategy includes the enantioselective kinetic resolution of racemic tropanes by means of acopper(I)catalyzed[ 3 + +2] cycloaddition and allows the preparation of two enantiopure products in ao ne-pot reaction in high yield and with high diastereo-and enantioselectivity by using one chiral catalyst.