Enamel rod relations in the developing rat incisor

Jodaikin, A.; Weiner, Stephen; Traub, W.

doi:10.1016/s0022-5320(84)80048-9

Cited by 25 publications

(18 citation statements)

References 10 publications

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“…4C). This texture is well documented and has been observed previously in the most mature region of canonical enamel [68]. Energy dispersive X-ray spectroscopy (EDS) revealed the mineral components to be composed primarily of calcium and phosphorus (Fig.…”

Section: 0 Results and Discussionsupporting

confidence: 77%

Biological synthesis of tooth enamel instructed by an artificial matrix

et al. 2010

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The regenerative capability of enamel, the hardest tissue in the vertebrate body, is fundamentally limited due to cell apoptosis following maturation of the tissue. Synthetic strategies to promote enamel formation have the potential to repair damage, increase the longevity of teeth and improve the understanding of the events leading to tissue formation. Using a self-assembling bioactive matrix, we demonstrate the ability to induce ectopic formation of enamel at chosen sites adjacent to a mouse incisor cultured in vivo under the kidney capsule. The resulting material reveals the highly organized, hierarchical structure of hydroxyapatite crystallites similar to native enamel. This artificially triggered formation of organized mineral demonstrates a pathway for developing cell fabricated materials for treatment of dental caries, the most ubiquitous disease in man. Additionally, the artificial matrix provides a unique tool to probe cellular mechanisms involved in tissue formation further enabling the development of tooth organ replacements.

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Section: 0 Results and Discussionsupporting

confidence: 77%

Biological synthesis of tooth enamel instructed by an artificial matrix

et al. 2010

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“…Needlelike enamel rods might be tens of microns long (up to 100 lm) but sometimes only 50 nm wide and 30 nm thick (Fig. 15 bottom; Avery 2001; Nanci 2012; Jandt 2006; Chen et al 2004;Rönnholm 1962;Nylen et al 1963;Miake et al 1993;Daculsi et al 1984;Jodaikin et al 1984;Bres and Hutchison 2002). They are quite different from the much smaller crystals of dentine and bone (Table 3), but all of them consist of biological apatite (Schroeder and Frank 1985;Brès et al 1990).…”

Section: Teethmentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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“…[5] The formation of crystal aggregates exhibiting such modes of construction and elaborately curved forms is however not confined to the living world or, more generally speaking, the influence of organic chemistry. There are some, but few, examples where mineralization in purely inorganic environments can give rise to unusual noncrystallographic architecAbstract: Upon slow crystallization from silica-containing solutions or gels at elevated pH, alkaline-earth carbonates spontaneously self-assemble into remarkable nanocrystalline ultrastructures.…”

Section: Introductionmentioning

confidence: 99%

Growth Behavior and Kinetics of Self‐Assembled Silica–Carbonate Biomorphs

Kellermeier

Melero‐García

Glaab

et al. 2012

Chemistry A European J

150

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Upon slow crystallization from silica-containing solutions or gels at elevated pH, alkaline-earth carbonates spontaneously self-assemble into remarkable nanocrystalline ultrastructures. These so-called silica biomorphs exhibit curved morphologies beyond crystallographic symmetry and ordered textures reminiscent of the hierarchical design found in many biominerals. The formation of these fascinating materials is thought to be driven by a dynamic coupling of the components' speciations in solution, which causes concerted autocatalytic mineralization of silica-stabilized nanocrystals over hours. In the present work, we have studied the precipitation kinetics of this unique system by determining growth rates of individual aggregates using video microscopy, and correlated the results with time-dependent data on the concentration of metal ions and pH acquired online during crystallization. In this manner, insight to the evolution of chemical conditions during growth was gained. It is shown that crystallization proceeds linearly with time and is essentially reaction controlled, which fits well in the proposed morphogenetic scenario, and thus, indirectly supports it. Measurements of the silica concentration in solution, combined with analyses of crystal aggregates isolated at distinct stages of morphogenesis, further demonstrate that the fraction of silica coprecipitated with carbonate during active growth is rather small. We discuss our findings with respect to the role of silica in the formation of biomorphs, and moreover, prove that the external silica skins that occasionally sheath the aggregates--previously supposed to be involved in the growth mechanism--originate from secondary precipitation after growth is already terminated.

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Enamel rod relations in the developing rat incisor

Cited by 25 publications

References 10 publications

Biological synthesis of tooth enamel instructed by an artificial matrix

Biological synthesis of tooth enamel instructed by an artificial matrix

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Growth Behavior and Kinetics of Self‐Assembled Silica–Carbonate Biomorphs

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