Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines

Abstract

Nanoparticulate delivery systems represent an area of particular promise for nanoneuromedicines. They possess significant potential for desperately needed therapies designed to combat a range of disorders associated with aging. As such, the field was selected as the focus for the 2014 meeting of the American Society for Nanomedicine. Regenerative, protective, immune modulatory, anti-microbial and anti-inflammatory products, or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the blood-brain barrier. Diagnostic imaging serves to precisely monitor disease onset and progression while neural stem cell replacement can regenerate damaged tissue through control of stem cell fates. These, taken together, can improve disease burden and limit systemic toxicities. Such enabling technologies serve to protect the nervous system against a broad range of degenerative, traumatic, metabolic, infectious and immune disorders.

Tetronic ® 904-Containing Polymeric Micelles Overcome the Overexpression of ABCG2 in the Blood–Brain Barrier of Rats and Boost the Penetration of the Antiretroviral Efavirenz into the CNS

“…Thus, conceiving innovative strategies to optimize the treatment of disease with drugs available on the market is of great value, especially when a direct translation into the clinical phase is envisioned. In this sense, the extensive development that has had clinical pharmacology, dealing with the effectiveness and safety of drugs in humans [44] has enabled the improvement of pharmacotherapy against HIV in children and pregnant women using the TDM as a fundamental tool [45][46][47][48][49]. However, it is known that drug levels in plasma often not reliably correlate with the accumulation thereof in tissues separated by barriers such as the BBB.…”

“…It is for this reason that in the last decade a large number of investigations that focus on nanotechnology have been developed. Regenerative, protective, immune modulatory, antimicrobial and anti-inflammatory products or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the BBB [49] in order to optimize pharmacotherapy.…”

Nanotechnology for mesenchymal stem cell therapies

“…Extensive studies have been published regarding the impact of nanotechnology in a broad spectrum of stem cell types, including pluripotent [47], neural [48,49], and hematopoietic [50] cells-driven tissue engineering.…”

Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo

“…Micro/nanoparticle formulations have been successfully developed for delivering therapeutic molecules, such as drugs, antibiotics, growth factors, and cytokines [22]. Both natural and synthetic polymers can be used for nanoparticle fabrication and encapsulating bioactive molecules.…”