A machine learning framework is developed to estimate ocean-wave conditions. By supervised training of machine learning models on many thousands of iterations of a physics-based wave model, accurate representations of significant wave heights and period can be used to predict ocean conditions. A model of Monterey Bay was used as the example test site; it was forced by measured wave conditions, ocean-current nowcasts, and reported winds.These input data along with model outputs of spatially variable wave heights and characteristic period were aggregated into supervised learning training and test data sets, which were supplied to machine learning models. These machine learning models replicated wave heights with a root-mean-squared error of 9 cm and correctly identify over 90% of the characteristic periods for the test-data sets. Impressively, transforming model inputs to outputs through matrix operations requires only a fraction (< 1/1, 000 th ) of the computation time compared to forecasting with the physics-based model. There are myriad reasons why predicting wave conditions is important to the economy. Surfers aside, there are fundamental reasons why knowledge of wave conditions for the next couple of days is important. For example, shipping routes can be optimized by avoiding rough seas thereby reducing shipping times. Another industry that benefits from knowledge of wave conditions is the $160B (2014) aquaculture industry [1], which could optimize harvesting operations accordingly. Knowledge of littoral conditions is critical to military and amphibious operations by Navy and Marine Corps teams. Also, predicting the energy production from renewable energy sources is critical to maintaining a stable electrical grid because many renewable energy sources (e.g., solar, wind, tidal, wave, etc.) are intermittent. For deeper market penetration of renewable energies, combinations of increased energy storage and improved energy-generation predictions will be required. The US Department of Energy has recently invested in the design, permitting, and construction of an open-water, grid-connected national Wave Energy Test Facility at Oregon State University [2]. Given that America's technically recoverable wave-energy resource is up to 1,230 TW-hr [3], there is a strong interest in developing this renewable resource [4]. Commercializationand deployment of wave-energy technologies will require not only addressing permitting and regulatory matters, but overcoming technological challenges, one of which is being able to provide an accurate prediction of energy generation. A requirement for any forecast is that an appropriately representative model be developed, calibrated, and validated. Moreover, this model must be