Enabling Adults With Severe Asthma to Exercise: A Qualitative Examination of the Challenges for Patients and Health Care Professionals

Apps, Lindsay; Chantrell, Stacey; Majd, Sally; Eglinton, Elizabeth; Singh, Sally; Murphy, Anna; Green, Ruth H.; Hudson, Nicky; Bradding, Peter; Evans, Rachael A.

doi:10.1016/j.jaip.2023.07.008

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…It is possible that greater improvements with these more strenuous activities might require more time on biologic treatment as well as physical reconditioning efforts by patients and health care professionals. 24 The observed improvement in the mean SGRQ total score (−10.2) is clinically meaningful, at more than twice the MCT of a 4-point reduction. This observed improvement is generally consistent with changes observed at similar timepoints in clinical trials.…”

Section: Discussionmentioning

confidence: 83%

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Quality of Life Improvements with Biologic Initiation Among Subspecialist-Treated US Patients with Severe Asthma

Soong,

Chipps,

Carr

et al. 2024

JAA

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Purpose Patients living with severe asthma (SA) experience multiple health-related quality of life (HRQoL) impairments. This study examined HRQoL changes after biologic treatment initiation among a large, real-world cohort of patients with SA. Patients and methods CHRONICLE is an ongoing observational study of subspecialist-treated adults with SA who receive biologics or maintenance systemic corticosteroids or are uncontrolled on high-dosage inhaled corticosteroids with additional controllers. Patients enrolled February 2018–February 2023 were asked to complete the St. George’s Respiratory Questionnaire (SGRQ) every 6 months (total score range of 0–100 [0=best possible health], meaningful change threshold is a 4-unit reduction in the total score). Changes in SGRQ responses from 6 months before initiation to 12 to 18 months after initiation were summarized. Results A total of 76 patients completed the SGRQ 0 to 6 months before and 12 to 18 months after biologic initiation. The mean (SD) SGRQ total score decreased from 52.2 (20.6) to 41.9 (23.8), with improvement across the symptoms (−14.5), activity (−11.0), and impacts (−8.3) components. For specific impairments reported by ≥50% of patients before biologic initiation, fewer reported each impairment after biologic initiation; the largest reductions were for “Questions about what activities usually make you feel short of breath these days [Walking outside on level ground]” (67% to 43%), “Questions about other effects that your respiratory problems may have on you these days [I feel that I am not in control of my respiratory problems]” (55% to 34%), and “Questions about your cough and shortness of breath these days [My coughing or breathing disturbs my sleep]” (63% to 45%). Conclusion In this real-world cohort of adults with SA, biologic initiation was associated with meaningful improvements in asthma-related HRQoL. These data provide further insight into the burden SA places on patients and the benefits of biologic treatment.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Quality of Life Improvements with Biologic Initiation Among Subspecialist-Treated US Patients with Severe Asthma

Soong,

Chipps,

Carr

et al. 2024

JAA

View full text Add to dashboard Cite

show abstract

“…The development of strategies that are able to achieve meaningful and maintained improvements in physical activity needs to incorporate the multifaceted interplay of disease and non-disease factors. Work in people with COPD [ 20 ], bronchiectasis [ 21 ] and severe asthma [ 22 ] has identified barriers to exercise and physical activity, including embarrassment related to symptoms and fear of exacerbating symptoms, which tell us that in order to improve engagement with physical activity, we will need to accommodate the needs of individuals.…”

mentioning

confidence: 99%