En el principio fue la zoonosis: One Health para combatir esta y futuras pandemias. Informe SESPAS 2022

Sánchez, Antonio; Contreras, A.; Corrales, J.C.; Fe, Christian de la

doi:10.1016/j.gaceta.2022.01.012

Cited by 14 publications

(13 citation statements)

References 33 publications

(50 reference statements)

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“…Se estima que el 61,6 % de los agentes patógenos que afectan al ser humano tienen carácter zoonótico. Además, el 75 % de los agentes patógenos considerados emergentes en la especie humana infectan a otro huésped animal [5]. El enfoque Una Salud plantea aumentar la investigación, integración de instituciones y gestión del riesgo.…”

Section: Resultsunclassified

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Riesgos del tráfico ilegal de aves silvestres en Bogotá (Colombia) según la perspectiva Una Salud

Calderón¹,

Plazas²

2022

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Section: Resultsunclassified

“…El concepto Una Salud hace referencia a un enfoque integrado y unificador que pretende equilibrar y optimizar de forma sostenible la salud de las personas, los animales y los ecosistemas [5], y el término zoonosis se refiere a enfermedades e infecciones que se transmiten de los animales al hombre y viceversa [6].…”

Section: Referente Conceptualunclassified

Riesgos del tráfico ilegal de aves silvestres en Bogotá (Colombia) según la perspectiva Una Salud

Calderón¹,

Plazas²

2022

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“…Indeed, around 89% of the 180 recognized RNA viruses with the potential to harm humans are zoonotic ( 162 ) and the global effort for emergent infectious disease surveillance and investigation is currently in the wrong place and must migrate to hotspots in lower latitudes, such as tropical Africa, Latin America and Asia ( 163 ). The spread of humans into new ecosystems owing to the requirement for more land, climate change, loss of biodiversity, and the trade and consumption of wild animals have all enhanced the risk of transmission of these pathogens from animals to humans and increases the likelihood of pandemics ( 41 , 164 , 165 ).…”

Section: The Influence Of Host Physiology and Environmental Influence...mentioning

confidence: 99%

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Pereira,

Diniz,

da Costa

et al. 2023

Front. Immunol.

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Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs between species and between individuals of the same species. Resistance includes innate and adaptive immune responses to control virus replication. Disease tolerance relies on the immune response allowing the coexistence of infections in the host with minimal or no clinical signs, while maintaining sufficient viral replication for transmission. Here, we compared the virome of bats, rodents and migratory birds and the molecular mechanisms underlying symptomatic and asymptomatic disease progression. We also explore the influence of the host physiology and environmental influences on RNA virus expression and how it impacts on the whole brain transcriptome of seemingly healthy semipalmated sandpiper (Calidris pusilla) and spotted sandpiper (Actitis macularius). Three time points throughout the year were selected to understand the importance of longitudinal surveys in the characterization of the virome. We finally revisited evidence that upstream and downstream regulation of the inflammatory response is, respectively, associated with resistance and tolerance to viral infections.

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“…In recent decades, increased imbalances in the human–animal–ecosystem interaction, 1 driven by climate change, loss of biodiversity, the demographic explosion, globalization, and/or increased contact with wildlife, have given rise to a significant increase in emerging infectious diseases, including the 2019 coronavirus disease (COVID‐19) 2 …”

Section: Introductionmentioning

confidence: 99%

Outpatient atorvastatin use and severe COVID‐19 outcomes: A population‐based study

Visos‐Varela,

Zapata‐Cachafeiro,

Pintos‐Rodríguez

et al. 2023

Journal of Medical Virology

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Evidence of the effect of statins on patients with coronavirus disease (2019) COVID-19 is inconsistent. The aim of this study was to evaluate the association between chronic use of statins-both overall and by active ingredient-and severe outcomes of COVID-19 (risk of hospitalization and mortality), progression to severe outcomes, and susceptibility to the virus. We conducted a populationbased case-control study with data from electronic records to assess the risk of (1) hospitalization: cases were patients admitted due to COVID-19 and controls were subjects without COVID-19; (2) mortality: cases were hospitalized patients who died due to COVID-19 and controls were subjects without COVID-19; (3) progression: cases were hospitalized COVID-19 subjects and controls were nonhospitalized COVID-19 patients; and (4) susceptibility: cases were patients with COVID-19 (both hospitalized and nonhospitalized) and controls were subjects without COVID-19.We collected data on 2821 hospitalized cases, 26 996 nonhospitalized cases, and 52 318 controls. Chronic use of atorvastatin was associated with a decreased risk of hospitalization (adjusted odds ratios [aOR] = 0.83; 95% confidence interval [CI]: 0.74-0.92) and mortality (aOR = 0.70; 95% CI: 0.53-0.93), attributable in part to a lower risk of susceptibility to the virus (aOR = 0.91; 95% CI: 0.86-0.96). Simvastatin was associated with a reduced risk of mortality (aOR = 0.59; 95% CI: 0.40-0.87). The wide degree of heterogeneity observed in the estimated odds ratios (ORs) of the different statins suggests that there is no class effect. The results of this real-world study suggest that chronic use of atorvastatin (and to a lesser degree, of simvastatin) is associated with a decrease in risk of severe COVID-19 outcomes.

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En el principio fue la zoonosis: One Health para combatir esta y futuras pandemias. Informe SESPAS 2022

Cited by 14 publications

References 33 publications

Riesgos del tráfico ilegal de aves silvestres en Bogotá (Colombia) según la perspectiva Una Salud

Riesgos del tráfico ilegal de aves silvestres en Bogotá (Colombia) según la perspectiva Una Salud

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Outpatient atorvastatin use and severe COVID‐19 outcomes: A population‐based study

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