Emulsions based on fatty acid from vegetable oils for cosmetics

Kunik, Oleksandra; Saribekova, Diana; Lazzara, Giuseppe; Cavallaro, Giuseppe

doi:10.1016/j.indcrop.2022.115776

Cited by 10 publications

(3 citation statements)

References 17 publications

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“…After hydration, permeability was enhanced and the intercellular space of the stratum corneum was dilated. Moreover, plant oil-based emulsion exhibits a higher level of antioxidant activity, and it provides a balance of moisture and fats on the skin for a longer time [42]. Therefore, we speculate that CLD contain a lot of fatty acids to change the skin's structure and enhance the drug's permeability into the skin.…”

Section: Discussionmentioning

confidence: 96%

Freeze-Dried Camelina Lipid Droplets Loaded with Human Basic Fibroblast Growth Factor-2 Formulation for Transdermal Delivery: Breaking through the Cuticle Barrier to Accelerate Deep Second-Degree Burn Healing

Gao,

Wang,

et al. 2023

Pharmaceuticals

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Transdermal administration of chemo therapeutics into burn healing may be an effective treatment to reduce toxic side effects and improve patient compliance for burns. As a transdermal delivery system, Camelina lipid droplets (CLDs) have received great attention due to their biocompatibility, high drug payload, and rapid absorption. However, the absorbed-related mechanisms of Camelina lipid droplets have not yet been reported. Thus, this paper not only demonstrated that CLD can accelerate skin burn healing through promoting hFGF2 absorption, but also elucidated the mechanism between the skin tissue and keratinocytes using Franz, HE staining, DSC, FTIR spectroscopy, and atomic force microscopy with the presence of CLD-hFGF2 freeze-dried powder. We found that the cumulative release rate of CLD-hFGF2 freeze-dried powder was significantly higher than that of free hFGF2 freeze-dried powder into the skin. At the same time, CLD can change the structure and content of lipids and keratin to increase the permeability of hFGF2 freeze-dried powder in skin tissue. Unlike the free state of hFGF2, the biophysical properties of single cells, including height and adhesion force, were changed under CLD-hFGF2 freeze-dried powder treatment. Meanwhile, CLD-hFGF2 freeze-dried powder was more easily taken up through keratinocytes without damaging cell integrity, which provided a new viewpoint for understanding the absorption mechanism with the CLD system for cellular physiology characteristics. Overall, our findings demonstrated that CLD could break through the stratum corneum (SC) barrier and elucidated the transport mechanism of lipid droplets in skin tissue, which provides a crucial guideline in drug delivery applications for future engineering.

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Section: Discussionmentioning

confidence: 96%

Freeze-Dried Camelina Lipid Droplets Loaded with Human Basic Fibroblast Growth Factor-2 Formulation for Transdermal Delivery: Breaking through the Cuticle Barrier to Accelerate Deep Second-Degree Burn Healing

Gao,

Wang,

et al. 2023

Pharmaceuticals

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“…Improving skin hydration through the use of emollient mixtures (from the group Isostearyl Isostearate, Propylene Glycol Dicaprylate/Dicaprate, PPG-3 Benzyl Ether Ethylhexanoate, PPG-3 Benzyl Ether Myristate, Triethylhexanoin, and Caprylic/Capric Triglyceride) in prototypes of olive-oil recipes for children in relation to olive oil containing only mineral oil was also demonstrated in work [64]. However, in the work published by Kunik et al [65], the authors examined the effect of various vegetable oils from the steppe zone of Southern Ukraine (Hypericum perforatum L., Silybum marianum L., Gaertn, Línum usitatíssimum L., Triticum aestivum L., Sésamum índicum L., Sinápis álba L., and Cucúrbita p é po L.) among others to moisturize and lubricate the skin. They found that the emulsion based on the proposed mixture of vegetable oils provided a good balance of moisture and fat on the skin for one hour, in contrast to the short-term effect of the emulsion based on mineral oil.…”

Section: Discussionmentioning

confidence: 99%

Natural or Synthetic Emollients? Physicochemical Properties of Body Oils in Relation to Selected Parameters of Epidermal Barrier Function

Ogorzałek,

Klimaszewska,

Mirowski

et al. 2024

Applied Sciences

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Emollients are valued ingredients of many cosmetic products and medical devices used to support the treatment and prevention of many skin diseases. Despite the fact that they are one of the oldest cosmetic ingredients, raw materials as well as new recipe solutions are constantly being sought, the main goal of which is to obtain products with the most favorable physicochemical properties while improving the hydration of the stratum corneum and softening and smoothing the skin. It should be noted that there are few scientific articles on the effect of emollients on the physicochemical and usable properties of emollient preparations of the body-oils type. The obtained formulations were subjected to physicochemical tests (dynamic viscosity, surface tension, contact angle, and color evaluation), and the degree of skin hydration and lubrication after application of the developed cosmetic oils was evaluated. Cosmetic oils based on natural emollients were characterized by weaker spreading abilities, which was confirmed by their higher viscosity, surface tension, and contact-angle results relative to those obtained for cosmetic oils based on synthetic emollients. In addition, it was found that the use of both groups of cosmetic oils based on natural and synthetic emollients leads to an increase in the degree of hydration of the skin and an increase in its oiliness. However, a higher increase in the degree of hydration and a lower decrease in the level of skin lubrication are observed after the application of body oils based on natural emollients.

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“…Improving skin hydration through the use of emollient mixtures (from the group: Isostearyl Isostearate, Propylene Glycol Dicaprylate/Dicaprate, PPG-3 Benzyl Ether Ethylhexanoate, PPG-3 Benzyl Ether Myristate, Triethylhexanoin and Caprylic/Capric Triglyceride) in prototypes of olive oil recipes for children in relation to olive oil containing only mineral oil was also demonstrated in work [51]. However, in work [52], the authors examined the effect of various vegetable oils from the steppe zone of southern Ukraine (Hypericum perforatum L., Silybum marianum L., Gaertn, Línum usitatíssimum L., Triticum aestivum L., Sésamum índicum L., Sinápis álba L., Cucúrbita p é po L.) among others to moisturize and lubricate the skin.…”

Section: Discussionmentioning

confidence: 99%

Natural or Synthetic Emollients? Physicochemical Properties of Body Oils in Relation to Selected Parameters of Epidermal Barrier Function

Ogorzałek,

Klimaszewska,

Mirowski

et al. 2023

Preprint

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Emollients are valued ingredients of many cosmetic products and medical devices used to support the treatment and prevention of many skin diseases. Despite the fact that they are one of the oldest cosmetic ingredients, raw materials as well as new recipe solutions are constantly being sought, the main goal of which is to obtain products with the most favorable physicochemical properties while improving the hydration of the stratum corneum and softening and smoothing the skin. This article presents the results of physicochemical tests of selected emollients: natural [Macadamia Integrifolia Seed Oil, Ricinus Communis Seed Oil, Prunus Amygdalus Dulcis, Vitis Vinifera (Grape) Seed Oil], semi-synthetic Caprylic/Capric Triglyceride and synthetic (Octyldodecanol, Dicaprylyl Carbonate, Dibutyl Adipate). Then, recipes for cosmetic oils were developed, differing in the type and concentration of emollients used. The obtained formulations were subjected to physicochemical tests (dynamic viscosity, surface tension, wetting angle, color assessment) and selected parameters of the epidermal barrier function (skin hydration and lubrication) were assessed. By appropriately selecting the type and concentration of emollients in the cosmetic oil recipe, it is possible to obtain products with the appropriate ability to spread on the skin, form a uniform protective layer on the skin and remain on the skin for a sufficiently long time. The observed improvement in skin hydration and the level of lubrication after using formulations containing mixtures of natural and semi-synthetic/synthetic emollients confirms that both groups of these raw materials can be components of cosmetic body oil recipes with an emollient effect, and the products themselves constitute an important element of the care of skin affected by the disease process.

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Emulsions based on fatty acid from vegetable oils for cosmetics

Cited by 10 publications

References 17 publications

Freeze-Dried Camelina Lipid Droplets Loaded with Human Basic Fibroblast Growth Factor-2 Formulation for Transdermal Delivery: Breaking through the Cuticle Barrier to Accelerate Deep Second-Degree Burn Healing

Freeze-Dried Camelina Lipid Droplets Loaded with Human Basic Fibroblast Growth Factor-2 Formulation for Transdermal Delivery: Breaking through the Cuticle Barrier to Accelerate Deep Second-Degree Burn Healing

Natural or Synthetic Emollients? Physicochemical Properties of Body Oils in Relation to Selected Parameters of Epidermal Barrier Function

Natural or Synthetic Emollients? Physicochemical Properties of Body Oils in Relation to Selected Parameters of Epidermal Barrier Function

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