Emulsions and microemulsions for ocular drug delivery

Peng, Cheng-Chun; Bengani, Lokendrakumar C.; Jung, Hyun Jung; Leclerc, Jenna L; Gupta, Chhavi; Chauhan, Anuj

doi:10.1016/s1773-2247(11)50010-3

Cited by 48 publications

(26 citation statements)

References 79 publications

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“…The surfactant helps in reducing the surface tension between the two phases. In addition, the use of a co-solvent helps in further reducing the interfacial tension 24 .…”

Section: Introductionmentioning

confidence: 99%

Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

Rout

Liu

2017

Sci Rep

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Photosensitization-based antimicrobial therapy (PAT) is an alternative therapy aimed at achieving bacterial inactivation. Researchers use various photosensitizers to achieve bacterial inactivation. However, the most widely used approach involves the use of photosensitizers dispersed in aqueous solution, which could limit the effectiveness of photodynamic inactivation. Therefore, the approaches to encapsulate the photosensitizer in appropriate vehicles can enhance the delivery of the photosensitizer. Herein, Toluidine Blue O (TBO) was the photosensitizer, and lipid nanoparticles were used for its encapsulation. The lipid nanoparticle-based delivery system has been tailor-made for decreasing the average size and viscosity and increasing the formulation stability as well as the wettability of skin. Usage of an appropriate vehicle will also increase the cellular uptake of the photosensitizer into the bacterial cells, leading to the damage on cell membrane and genomic DNA. Evidence of effectiveness of the developed PAT on planktonic bacteria and biofilms was examined by fluorescence microscopy and scanning electron microscopy. Lipid nanoparticles protected the photosensitizer from aggregation and made the application easy on the skin as indicated in data of size distribution and contact angle. The use of lipid nanoparticles for encapsulating TBO could enhance photosensitization-based antimicrobial therapy as compared to the aqueous media for delivering photosensitizers.

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“…The surfactant helps in reducing the surface tension between the two phases. In addition, the use of a co-solvent helps in further reducing the interfacial tension 24 .…”

Section: Introductionmentioning

confidence: 99%

Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

Rout

Liu

2017

Sci Rep

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“…Due to these clearance mechanisms and ocular barriers, less than 5% of the total administered drug reaches the aqueous humor 7. For example, after administration of a common eye‐drop solution containing 0.05% cyclosporine to treat dry eye syndrome, more than 95% of the drug reaches systemic circulation through transnasal or conjunctival absorption 8…”

Section: Challenges Of Conventional Ophthalmic Drug Deliverymentioning

confidence: 99%

Nanomaterials for Ocular Drug Delivery

Liu

Jones

2012

Macromolecular Bioscience

165

125

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Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause adverse effects in the eye. Recently, an increasing number of scientists have turned to nanomaterial-based drug delivery systems to address the challenges faced by conventional methods. This paper highlights recent applications of various nanomaterials, such as polymeric micelles, hydrogels, liposomes, niosomes, dendrimers, and cyclodextrins as ocular drug delivery systems to enhance the bioavailability of ocular therapeutic agents.

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“…Microemulsions offer a promising route for designing extended drug delivery systems due to improved drug solubilization, ease of preparation and administration, long shelf-life, improved corneal penetration and improved residence time [17,18,19,20]. Cationic emulsions increase the bioavailability of ophthalmic drugs in comparison to emulsions with no charge or negative charge [17,21,22]. The addition of cationic surfactant forms positively charged drops in microemulsions, which can bind to the negatively charged corneal epithelium, leading to increased residence time and drug permeability through the corneal epithelium [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Cationic Surfactant on Microemulsion Globules and Drug Release from Hydrogel Contact Lenses

Torres-Luna

Koolivand

et al. 2019

Pharmaceutics

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The present study evaluates the in vitro release of diclofenac sodium (DFNa) from contact lenses based on poly-2-hydroxyethyl methacrylate (pHEMA) hydrogels containing an embedded microemulsion to extend release duration. The oil (ethyl butyrate)-in-water microemulsion systems are prepared with two non-ionic surfactants, Brij 97 or Tween 80, together with a long-alkyl chain cationic surfactant, cetalkonium chloride (CKC). Without CKC, Brij 97 or Tween 80-based microemulsions showed average droplet sizes of 12 nm and 18 nm, respectively. The addition of CKC decreased the average droplet sizes to 2–5 nm for both non-ionic surfactants. Such significant reduction in the average droplet size corresponds to an increase in the DFNa release duration as revealed by the in vitro experiments. Contact lens characterization showed that important properties such as optical transparency and water content of Brij 97-based contact lenses with cationic microemulsions was excellent. However, the optical transparency of the corresponding Tween 80 based contact lenses was unsatisfactory. The results indicate that cationic microemulsion-laden contact lenses can benefit from combinatory effects of microemulsions and cationic surfactant at low CKC weight percentage, e.g., with the release of 70% of the drug in 45, 10, and 7 h for B97-CKC-0.45%, CKC-0.45%, and control lenses, respectively. However, the microemulsion effect on extending DFNa release became negligible at the highest CKC weight percentage (1.8%).

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Emulsions and microemulsions for ocular drug delivery

Cited by 48 publications

References 79 publications

Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

Nanomaterials for Ocular Drug Delivery

Effect of a Cationic Surfactant on Microemulsion Globules and Drug Release from Hydrogel Contact Lenses

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