Emulsion templated three-dimensional porous scaffolds for drug delivery

Yadav, Anilkumar; Agrawal, Meenal; Srivastava, Rajiv K.

doi:10.1016/b978-0-323-96117-2.00007-8

Cited by 2 publications

(1 citation statement)

References 134 publications

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“…HIPEs were conventionally developed from aqueous emulsions utilizing free radical polymerization of vinylic monomers; therefore, the use of water-sensitive polymerization techniques or high temperatures was severely restricted until now. The introduction of oil-in-oil nonaqueous HIPEs overcame these major restrains of conventional systems. − Over the years, polyHIPEs have been fabricated using a wide range of polymers and various polymerization techniques including free radical polymerization, atom transfer radical polymerization, reversible addition–fragmentation chain transfer, and ring-opening polymerization (ROP), etc . Further, various studies indicating the influence of polyHIPE composition on material properties like mechanical strength, liquid uptake capacity, thermal behavior, biodegradation, etc., have been reported.…”

Section: Introductionmentioning

confidence: 99%

Unique Crystallization Characteristics of Pickering High Internal Phase Emulsion Templated Porous Constructs

Agrawal,

Nandan,

Srivastava

2024

Langmuir

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To study the crystallization behavior of polymeric chains under the influence of porosity, the thermal properties of various nonporous and porous poly(ε-caprolactone) (PCL) based constructs were investigated. Porous cross-linked PCL nanocomposite constructs were fabricated utilizing in situ polymerization of CL-based surfactant-free Pickering high internal phase emulsions (HIPEs), stabilized using modified fumed silica nanoparticles (mSiNP) at a minimal concentration of 0.6 wt %. The corresponding nanocomposite constructs exhibited polyhedral pore morphology with significant pore roughness due to the presence of mSiNP. DSC thermograms of nonporous constructs illustrated diminished crystallization temperature and kinetics upon cross-linking and inclusion of mSiNP which confirmed suppressed mobility of polymer chains. Further introduction of porosity led to substantial supercooling, resulting in crystallization temperatures as low as −24 °C. Changes in the crystal structure of various nonporous and porous constructs were also studied using XRD. The crystallization behavior of porous constructs was finally evaluated using Jeziorny, Ozawa, and Mo theories under nonisothermal conditions. Significant deviation from the theoretical model, as observed in the case of porous constructs, implied a complex crystallization mechanism that eventually was not only controlled by the chain immobility due to cross-linking but also heterogeneity present in the wall thickness of the constructs. The unique meltingcrystallization phenomenon observed in such constructs may further be expanded to other systems of high heat capacity for utilization as energy storage materials.

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Section: Introductionmentioning

confidence: 99%

Unique Crystallization Characteristics of Pickering High Internal Phase Emulsion Templated Porous Constructs

Agrawal,

Nandan,

Srivastava

2024

Langmuir

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Depletion Flocculation of High Internal Phase Pickering Emulsion Inks: A Colloidal Engineering Approach to Develop 3D Printed Porous Scaffolds with Tunable Bioactive Delivery

Shahbazi,

Jäger,

Huc-Mathis

et al. 2024

ACS Appl. Mater. Interfaces

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Flocculation is a type of aggregation where the surfaces of approaching droplets are still at distances no closer than a few nanometers while still remaining in close proximity. In a high internal-phase oil-in-water (O/W) emulsion, the state of flocculation affects the bulk flow behavior and viscoelasticity, which can consequently control the three-dimensional (3D)-printing process and printing performance. Herein, we present the assembly of O/W Pickering high-internal-phase emulsions (Pickering-HIPEs) as printing inks and demonstrate how depletion flocculation in such Pickering-HIPE inks can be used as a facile colloidal engineering approach to tailor a porous 3D structure suitable for drug delivery. Pickering-HIPEs were prepared using different levels of cellulose nanocrystals (CNCs), co-stabilized using “raw” submicrometer-sized sustainable particles from a biomass-processing byproduct. In the presence of this sustainable particle, the higher CNC contents facilitated particle-induced depletion flocculation, which led to the formation of a mechanically robust gel-like ink system. Nonetheless, the presence of adsorbed particles on the surface of droplets ensured their stability against coalescence, even in such a highly aggregated system. The gel structures resulting from the depletion phenomenon enabled the creation of high-performance printed objects with tunable porosity, which can be precisely controlled at two distinct levels: first, by introducing voids within the internal structure of filaments, and second, by generating cavities (pore structures) through the elimination of the water phase. In addition to printing efficacy, the HIPEs could be applied for curcumin delivery, and in vitro release kinetics demonstrated that the porous 3D scaffolds engineered for the first time using depletion-flocculated HIPE inks played an important role in 3D scaffold disintegration and curcumin release. Thus, this study offers a unique colloidal engineering approach of using depletion flocculation to template 3D printing of sustainable inks to generate next-generation porous scaffolds for personalized drug deliveries.

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Emulsion templated three-dimensional porous scaffolds for drug delivery

Cited by 2 publications

References 134 publications

Unique Crystallization Characteristics of Pickering High Internal Phase Emulsion Templated Porous Constructs

Unique Crystallization Characteristics of Pickering High Internal Phase Emulsion Templated Porous Constructs

Depletion Flocculation of High Internal Phase Pickering Emulsion Inks: A Colloidal Engineering Approach to Develop 3D Printed Porous Scaffolds with Tunable Bioactive Delivery

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