Emulsion Interfacial Synthesis of Asymmetric Janus Particles

Wang, Yanhong; Zhang, Chengliang; Tang, Can; Li, Jing; Shen, Ke; Liu, Jiguang; Qu, Xiaozhong; Li, Jiaoli; Wang, Qian; Yang, Zhenzhong

doi:10.1021/ma102945t

Cited by 84 publications

(84 citation statements)

References 53 publications

(27 reference statements)

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“…S6 †). 37,43 Such JP hemisphere morphology is also in line with the prediction by the extended theory of Torza and Mason, where the contact angle q between two phases at the three-phase equilibrium point of JP can be calculated based on Torza-Mason's equation (Fig. S6 †).…”

Section: Discussionsupporting

confidence: 85%

Mechanistic formation of drug-encapsulated Janus particles through emulsion solvent evaporation

et al. 2018

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Janus particles are emerging as structurally unique drug carriers with the potential to deliver multiple drugs and agents. Although synthesis methods have been extensively explored to fabricate Janus particles, it remains a challenge to generate drug-loaded Janus particles through an economical, high throughput technique. Here, we report the formation of the first drug-loaded, micro-scale Janus particles prepared using a single-step emulsion solvent evaporation approach. Our results revealed that both the net charge of drug molecules (i.e. glibenclamide, tolbutamine, rapamycin and lidocaine) and polymer weight ratio (i.e.poly(lactic-co-glycolic) and polycaprolactone) were critical in determining the formation of Janus particles.The formation of drug-loaded Janus particles was proven to be thermodynamically-driven in accordance to the classical equilibrium spreading coefficient theory, which is strongly governed by interfacial tensions.Specifically, comparable interfacial tensions between the two interacting polymers with the water phase were identified to be key criteria to achieve the Janus particles hemispheric structure. Such interfacial tensions were amenable, and were found to be highly dependent on the interfacial charge density attributed to both drug and polymer ratio. Hereby, this study provides a mechanistic insight into the fabrication of drug-loaded Janus particles and paves an important path towards large-scale production of Janus particles using a simplified, single-step emulsion solvent evaporation strategy.

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Section: Discussionsupporting

confidence: 85%

Mechanistic formation of drug-encapsulated Janus particles through emulsion solvent evaporation

et al. 2018

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“…By controlling the interfacial tensions at the triple phase contact line, the spreading coefficients of polymer can be modified. Thus, the UFOlike Janus particles are prepared [34] (Fig. 14).…”

Section: Ps Hollow Spheresmentioning

confidence: 99%

Design, Synthesis, and Application of Anisotropic Janus Particles

Zhang¹,

Liang²,

Yang³

2017

Soft, Hard, and Hybrid Janus Structures

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“…The representative TEM and SEM images of ASRs in Figure 1 b-e clearly indicate two distinguished blocks of the asymmetric "diblock" rods. [16] The chemical inhomogeneity of ASRs was further confirmed by the preferential physical absorption of a hydrophilic dye (rhodamine B) onto the hydrophilic block. The hydrophobic tubelike block has a wall thickness of approximately 5 nm (see the Supporting Information).…”

mentioning

confidence: 94%

Wet‐Chemical Synthesis of Amphiphilic Rodlike Silica Particles and their Molecular Mimetic Assembly in Selective Solvents

Hourwitz

et al. 2012

Angewandte Chemie

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Nano-and micrometer-sized colloidal particles (CPs) with shape anisotropy (e.g., rod-shaped particles) and chemical heterogeneity (e.g., patchy particles) have attracted significant attention owing to their fascinating optical, electronic, and magnetic properties in materials sciences. [1][2][3] Self-assembly of such colloidal building blocks as "atoms" or "molecules" (so-called "colloidal molecules") into novel architectures or ordered ensembles provides new opportunities for engineering materials and devices with otherwise unattainable properties. [4,5] In particular, assembly of rodlike CPs with two or multiple blocks can potentially produce a variety of spectacular structures, which arise from the interplay and competition of the structural asymmetry of rods, the orientation, and phase segregation of blocks. [1a, 6] Currently, the preparation of such segmented rodlike CPs mainly relies on templated electrochemical deposition, [7] galvanic replacement, [8] phase separation, [3f] chemical vapor deposition, [9] hot coordinating solvents method, [10] and cation-exchange reactions. [11] These approaches, however, are either limited to crystalline or conductive materials, or they require the use of templates. The synthesis of segmented rodlike particles from amorphous materials (e.g., SiO 2 ) still remains a challenge.From the study of the assembly of colloidal molecules one can fundamentally learn and understand the general principles of atomic and molecular interactions using CPs as model systems, [1,12] and one can practically use the strategy known from the self-assembly of atoms or molecules as an inspiration for the design of new functional materials of CPs, such as nonconventional photonic crystals. [3d, 13] Anisotropic rodlike CPs with hydrophilic and hydrophobic blocks are typical models for the investigation of assembly behaviors and molecular interactions of amphiphilic molecules (AMs). [8] The Mirkin group reported an inspiring example of template-directed assembly of two-segment gold-polypyrrole (Au-PPy) rods prepared by a templating method. [7a] The assembly of Au-PPy rods is driven by a delicate balance of [*] Dr.

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Emulsion Interfacial Synthesis of Asymmetric Janus Particles

Cited by 84 publications

References 53 publications

Mechanistic formation of drug-encapsulated Janus particles through emulsion solvent evaporation

Mechanistic formation of drug-encapsulated Janus particles through emulsion solvent evaporation

Design, Synthesis, and Application of Anisotropic Janus Particles

Wet‐Chemical Synthesis of Amphiphilic Rodlike Silica Particles and their Molecular Mimetic Assembly in Selective Solvents

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