Emulsion gels and oil-filled aerogels as curcumin carriers: Nanostructural characterization of gastrointestinal digestion products

Fontes-Candia, Cynthia; Martínez, Juan Carlos; López‐Rubio, Amparo; Salvia‐Trujillo, Laura; Martı́n-Belloso, Olga; Martínez‐Sanz, Marta

doi:10.1016/j.foodchem.2022.132877

Cited by 14 publications

(5 citation statements)

References 41 publications

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“…This could limit the access of bile salts and pancreatic lipase to the surface of the oil droplets and, therefore, reduce digestibility. Similar results were reported by Fontes-Candia et al [ 28 ] in a GE with curcumin incorporated in the oil phase. These authors reported that the presence of curcumin limited the formation of the mixed bile salt-digestion products lamellae/micelles, and induced the formation of a greater number of larger vesicles, curcumin being most likely located within the interior of these structures.…”

Section: Resultssupporting

confidence: 91%

Impact of Silicon Addition on the Development of Gelled Pork Lard Emulsions with Controlled Lipid Digestibility for Application as Fat Replacers

Cofrades,

Hernández-Martín,

Garcimartín

et al. 2023

Gels

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Pork lard gelled emulsions stabilized with two proteins [soy protein concentrate (SPC) or a pork rind protein extract (PRP)], both with and without added silicon (Si) from diatomaceous earth powder, were gelled by microbial transglutaminase and к-carrageenan. These gelled emulsions (GEs), intended as fat replacers, were evaluated in different aspects, including microstructure and technological properties during chilling storage. In addition, in vitro gastrointestinal digestion (GID) with an analysis of lipolysis and lipid digestibility was also evaluated. All GEs showed adequate technological properties after 28 days of chilling storage, although the SPC-stabilized GEs showed better gravitational and thermal stability (~4% and ~6%, respectively) during chilling storage than the PRP-stabilized ones (~8 and ~12%, respectively). PRP developed larger flocculates restricting pancreatic lipase-mediated lipolysis during intestinal digestion. The addition of Si to both GE structures protected them against disruption during in vitro digestion. Accordingly, Si appears to slow down fat digestion, as reflected by higher triacylglycerides content after GID (15 and 22% vs. 10 and 18% in GEs without Si) and could become a potential candidate for use in the development of healthier meat products.

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Section: Resultssupporting

confidence: 91%

Impact of Silicon Addition on the Development of Gelled Pork Lard Emulsions with Controlled Lipid Digestibility for Application as Fat Replacers

Cofrades,

Hernández-Martín,

Garcimartín

et al. 2023

Gels

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“…In gastrointestinal applications, curcumin’s potential lies in enhancing bioavailability and cellular uptake [ 40 , 41 , 42 , 43 , 44 ]. Various formulations offer extended-release properties, gastric floatability, and sustained drug release, contributing to improved therapeutic outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Effective carriers with controlled release for gastrointestinal applications [41] Dry suspension floating in situ gelling system of curcumin Locally treating gastric ulcers, controlled drug release in gastric environment [42] Gastroretentive floating in situ gelling system with curcumin Extended gastric retention for improved therapeutic effectiveness [43] Composite emulsion gels with whey protein isolate/kappa-carrageenan Controlled release and improved stability, gastrointestinal fate study [44] Table 1. Cont.…”

Section: Methodsmentioning

confidence: 99%

“…The researchers observed distinct behavior and structural changes of the gels during in vitro digestion influenced by the presence of curcumin. This investigation provides valuable insights into the interaction between curcumin and emulsion gels, shedding light on their potential application in gastrointestinal delivery systems [ 41 ].…”

Section: Curcumin Delivery Systemsmentioning

confidence: 99%

“…Gastrointestinal health has also been a focus of curcumin delivery system research. Curcumin-loaded Pickering emulsions, emulsion gels, and oil-filled aerogels offer potential solutions for enhancing curcumin’s bioavailability and stability during digestion [ 40 , 41 ]. Gastroretentive floating in situ gelling systems have been formulated for gastric ulcer treatment, targeting Helicobacter-pylori-associated ulcers [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

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Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications

Omidian

Wilson

Chowdhury

2023

Gels

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Curcumin, a potent active compound found in turmeric and Curcuma xanthorrhiza oil, possesses a wide range of therapeutic properties, including antibacterial, anti-inflammatory, antioxidant, and wound healing activities. However, its clinical effectiveness is hindered by its low bioavailability and rapid elimination from the body. To overcome these limitations, researchers have explored innovative delivery systems for curcumin. Some promising approaches include solid lipid nanoparticles, nanomicelle gels, and transdermal formulations for topical drug delivery. In the field of dentistry, curcumin gels have shown effectiveness against oral disorders and periodontal diseases. Moreover, Pickering emulsions and floating in situ gelling systems have been developed to target gastrointestinal health. Furthermore, curcumin-based systems have demonstrated potential in wound healing and ocular medicine. In addition to its therapeutic applications, curcumin also finds use as a food dye, contraception aid, corrosion-resistant coating, and environmentally friendly stain. This paper primarily focuses on the development of gel compositions of curcumin to address the challenges associated with its clinical use.

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Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study

Velderrain-Rodríguez

Fontes-Candia

López‐Rubio

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Emulsion gels and oil-filled aerogels as curcumin carriers: Nanostructural characterization of gastrointestinal digestion products

Cited by 14 publications

References 41 publications

Impact of Silicon Addition on the Development of Gelled Pork Lard Emulsions with Controlled Lipid Digestibility for Application as Fat Replacers

Impact of Silicon Addition on the Development of Gelled Pork Lard Emulsions with Controlled Lipid Digestibility for Application as Fat Replacers

Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications

Polysaccharide-based structured lipid carriers for the delivery of curcumin: An in vitro digestion study

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