Emulsion-Based Delivery Systems to Enhance the Functionality of Bioactive Compounds: Towards the Use of Ingredients from Natural, Sustainable Sources

Teixé-Roig, Júlia; Oms‐Oliu, Gemma; Odriozola-Serrano, Isabel; Belloso, Olga Martín

doi:10.3390/foods12071502

Cited by 16 publications

(9 citation statements)

References 148 publications

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“…Reduced droplet diameters within the emulsion have the potential to augment the bioavailability of bioactive compounds that are found in ostrich oil. The enhanced bioavailability of the oil’s beneficial components facilitates their improved absorption and utilization by epidermis cells or microbes [ 55 ]. In order to enhance the stability of the formulation, emulsions frequently incorporate emulsifiers and stabilizers (e.g., Span 20 and Tween 80) as stabilizing agents.…”

Section: Discussionmentioning

confidence: 99%

Development and Evaluation of a Stable Oil-in-Water Emulsion with High Ostrich Oil Concentration for Skincare Applications

Ponphaiboon,

Limmatvapirat,

Limmatvapirat

2024

Molecules

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This study investigates the development of an oil-in-water (O/W) emulsion enriched with a high concentration of ostrich oil, recognized for its abundant content of oleic acid (34.60 ± 0.01%), tailored for skincare applications. Using Span and Tween emulsifiers, we formulated an optimized emulsion with 20% w/w ostrich oil and a 15% w/w blend of Span 20 and Tween 80. This formulation, achieved via homogenization at 3800 rpm for 5 min, yielded the smallest droplet size (5.01 ± 0.43 μm) alongside an appropriate zeta potential (−32.22 mV). Our investigation into the influence of Span and Tween concentrations, types, and ratios on the stability of 20% w/w ostrich oil emulsions, maintaining a hydrophile–lipophile balance (HLB) of 5.5, consistently demonstrated the superior stability of the optimized emulsion across various formulations. Cytotoxicity assessments on human dermal fibroblasts affirmed the safety of the emulsion. Notably, the emulsion exhibited a 52.20 ± 2.01% inhibition of linoleic acid oxidation, surpassing the 44.70 ± 1.94% inhibition observed for ostrich oil alone. Moreover, it demonstrated a superior inhibitory zone against Staphylococcus aureus (12.32 ± 0.19 mm), compared to the 6.12 ± 0.15 mm observed for ostrich oil alone, highlighting its enhanced antioxidant and antibacterial properties and strengthening its potential for skincare applications. The optimized emulsion also demonstrates the release of 78.16 ± 1.22% of oleic acid across the cellulose acetate membrane after 180 min of study time. This successful release of oleic acid further enhances the overall efficacy and versatility of the optimized emulsion. Stability assessments, conducted over 6 months at different temperatures (4 °C, 25 °C, 45 °C), confirmed the emulsion’s sustained physicochemical and microbial stability, supporting its promise for topical applications. Despite minor fluctuations in acid values (AV) and peroxide values (PV), the results remained within the acceptable limits. This research elucidates the crucial role of emulsification in optimizing the efficacy and stability of ostrich oil in skincare formulations, providing valuable insights for practical applications where stability is paramount.

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Section: Discussionmentioning

confidence: 99%

Development and Evaluation of a Stable Oil-in-Water Emulsion with High Ostrich Oil Concentration for Skincare Applications

Ponphaiboon,

Limmatvapirat,

Limmatvapirat

2024

Molecules

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“…Lipid-based drug delivery systems (LBDDSs) can also include emulsion systems, which utilize lipid components to create stable emulsions for improved drug delivery. Here are some classes of emulsion systems within LBDDS [ 117 , 118 ]: Micro/nanoemulsions . Micro/nanoemulsions are transparent, thermodynamically stable systems formed from oil, water, and surfactants.…”

Section: Oral Bioavailability Enhancement Approachesmentioning

confidence: 99%

Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents

Preeti,

Sambhakar,

Malik

et al. 2024

International Journal of Hypertension

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The lipid-based drug delivery system (LBDDS) is a well-established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis. Various LBDDSs verified to be an efficacious mechanism for monitoring hypertension systems are SEDDS (self-nano emulsifying drug delivery), nanoemulsion, microemulsions, vesicular systems (transferosomes and liposomes), and solid lipid nanoparticles. LBDDSs overcome the shortcomings that are associated with antihypertensive agents because around fifty percent of the antihypertensive agents experience a few drawbacks including short half-life because of hepatic first-pass metabolism, poor aqueous solubility, low permeation rate, and undesirable side effects. This review emphasizes antihypertensive agents that were encapsulated into the lipid carrier to improve their poor oral bioavailability. Incorporating cutting-edge technologies such as nanotechnology and targeted drug delivery, LBDDS holds promise in addressing the multifactorial nature of hypertension. By fine-tuning drug release profiles and enhancing drug uptake at specific sites, LBDDS can potentially target renin-angiotensin-aldosterone system components, sympathetic nervous system pathways, and endothelial dysfunction, all of which play crucial roles in hypertension pathophysiology. The future of hypertension management using LBDDS is promising, with ongoing reviews focusing on precision medicine approaches, improved biocompatibility, and reduced toxicity. As we delve deeper into understanding the intricate mechanisms underlying hypertension, LBDDS offers a pathway to develop next-generation antihypertensive therapies that are safer, more effective, and tailored to individual patient needs.

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“…[8,9] The preparation method and component ratio, particularly the oily phase/aqueous phase ratio, significantly impact the size and properties of emulsion systems. [5,7] In the fields of medicine and nutrition, emulsion systems can be tailored to have droplets ranging from the nanoscale to microscale. Nanoemulsions (NEs), with droplet sizes ranging from nanometers to submicron ( � 300-500 nm), can be successfully produced through various methods, consisting of high-energy methods (ultrasonication, micro-fluidization, high-pressure homogenization, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, emulsion systems have been extensively researched and developed as essential components for various applications, including biomedicine, food, cosmetics, agriculture, personal care, etc. [1][2][3][4] They are commonly utilized as vehicles to encapsulate and deliver bioactive agents, such as nutraceuticals [5][6][7] and vitamins. [8,9] The preparation method and component ratio, particularly the oily phase/aqueous phase ratio, significantly impact the size and properties of emulsion systems.…”

Section: Introductionmentioning

confidence: 99%

Optimizing Preparation of Fish Scale Collagen Peptide/Sacha Inchi (Plukenetia volubilis L.) Seed Oil Nanoemulsion

Vu,

Mai

et al. 2024

ChemistrySelect

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This study presents results of extracting hydrolyzed collagen peptide from fresh‐water fish scale and using it to prepare a nanoemulsion based on Sacha inchi (Plukenetia volubilis L.) seed oil and collagen peptide. The sacha inchi seed oil is extracted from the seeds of Sacha Inchi (abbreviated as sachi) plant and contains approximate 45 % triple omega 3–6‐9 (ω‐3, ω‐6, ω‐9) content. Pseudo‐ternary phase diagrams of three components: aqueous collagen solution, sachi seed oil, and surfactant/co‐surfactant (Smix) have been constructed. The parameters including the composition of Smix, sachi seed oil, and aqueous collagen solution have been selected to optimize the technology factors for the emulsion process. A quadratic regression equation was chosen, and experimental planning following the Box‐Behnken model using response surface methodology was used to optimize the preparation conditions for the nanoemulsion. The average droplet size of the emulsion systems is the object function for optimization. The Smix is a mixture of surfactant (Tween80) and propylene glycol (PG) with different ratios of Tween80/PG of 1/1, 2/1, 3/1, and 4/1, corresponding to the formation of four emulsion systems, code 1, 2, 3, 4, respectively. The optimal parameters for each emulsion system are different, however, the aqueous collagen solution contains a higher proportion in emulsions. Under the optimal conditions, the predicted values of the objective function of emulsions code 1–code 4 ranged from 95.62 to 185.14 nm, increasing together with the Tween80 ratio in Smix. The experiment values of the objective function of emulsions code 1–code 4 prepared under the optimal conditions are 104.22, 133.70, 159.27, and 207.87 nm, respectively. These values are close to the predicted values, suggesting that the suitability of the experiment and theory. Additionally, the stability of the nanoemulsion prepared under the optimal conditions is also evaluated. A stable nanoemulsion is potentially for loading nutraceuticals and vitamins for applications in personal health care and medicinal fields.

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Emulsion-Based Delivery Systems to Enhance the Functionality of Bioactive Compounds: Towards the Use of Ingredients from Natural, Sustainable Sources

Cited by 16 publications

References 148 publications

Development and Evaluation of a Stable Oil-in-Water Emulsion with High Ostrich Oil Concentration for Skincare Applications

Development and Evaluation of a Stable Oil-in-Water Emulsion with High Ostrich Oil Concentration for Skincare Applications

Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents

Optimizing Preparation of Fish Scale Collagen Peptide/Sacha Inchi (Plukenetia volubilis L.) Seed Oil Nanoemulsion

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