Emulgels- A Novel Approach for Topical Drug Delivery

Sushma, Gunuputi; Pravalika, T.; Sri, Bhavya; Priyanaka, P.; Priya, P. Vishnu; Sharma, Jitendra

doi:10.47583/ijpsrr.2021.v67i01.024

Cited by 9 publications

(4 citation statements)

References 1 publication

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“…Emulgels show better loading capacity than some other novel drug delivery systems such as niosomes and liposomes which may result in leakage and lesser entrapment efficiency due to their vesicular nature. However, emulgels have a network that can show comparatively better loading capacity and entrapment of active substances [ 8 , 118 ]. Preparation of vesicular drug delivery systems such as niosomes and liposomes needs intensive sonication which may lead to drug degradation and leakage.…”

Section: Advantages Of Emulgel Formulationsmentioning

confidence: 99%

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Milutinov,

Krstonošić,

Ćirin

et al. 2023

Polymers

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Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrier for hydrophobic substances and it determines the occlusive and sensory properties of the product. The emulsifiers are used to promote emulsification during production and to ensure emulsion stability. The choice of emulsifying agents is based on their capacity to emulsify, their toxicity, and their route of administration. Generally, gelling agents are used to increase the consistency of formulation and improve sensory properties by making these systems thixotropic. The gelling agents also impact the release of active substances from the formulation and stability of the system. Therefore, the aim of this review is to gain new insights into emulgel formulations, including the components selection, methods of preparation, and characterization, which are based on recent advances in research studies.

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Section: Advantages Of Emulgel Formulationsmentioning

confidence: 99%

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Milutinov,

Krstonošić,

Ćirin

et al. 2023

Polymers

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“…If a thickening agent is available, the nanoemulgel preparation stability will be improved owing to a drop in surface tension and also an improvement in viscosity and adhesion when applied topically. Nanoemulgel also has the advantages of being easy to distribute, clean, and non-greasy [35].…”

Section: Nano-emulgelmentioning

confidence: 99%

Novel Cosmeceutical Formulations: A Better Approach to Photoprotection

et al. 2022

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Using photoprotection, it is possible to prevent UV-induced skin damage and skin cancers. Radiation that falls between visible light and X-rays is defined as ultraviolet. By biological consequences, UVR is classified into five types, UVA, UVB, UVC, Far UV, and Vacuum UV. However, sunscreen functions as an essential device in our accessories of photo protective action, whose goal is to protect us from sunburn and from the harmful effects of ultraviolet radiation. Sunscreens are categorized as systemic and topical, depending on how they are administered. Again, topical sunscreen divides into organic and inorganic sunscreen. Despite the main objective of sunscreen is to be secure, chemically inert, non-toxic and protected against wide-ranging radiation so as to combat photo aging and photocarcinogenesis. But chemical and synthetic sunscreen causes several undesirable effects, which is a matter of concern. Therefore, a better and safer photoprotective agent is needed in sunscreen. In this regard, nanoparticles, or nanoparticulate systems, are becoming increasingly popular as a form of sunscreen for many different reasons, such as boosting SPF and stability, customizing the release profile, and minimizing adverse effects. In this review, the nanoformulation approach of sunscreen has been described, which has more demand than conventional sunscreen, including liposomes, ethosomes, microemulsions, nano-emulgel, solid-lipid nanoparticles, nano-transferosomes, and niosomes which received a lot of attention worldwide. In short, this review provides an outline of novel advent to sunscreen formulations.

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“…Advantages in terms of spreadability, adhesion, viscosity, and extrusion contribute to their better efficiency. These transparent, attractive, and non-greasy novel vehicles for drug delivery are obtained by conversion of classic emulsions by adding a gelling agent in the water phase [20,21].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Skin Penetration of Ascorbyl Palmitate Achieved via Liposomal Encapsulation: Tape Stripping Evaluation

Jovanović,

Tadic,

Martinović

et al. 2024

Preprint

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L-ascorbic acid represents one of the most potent antioxidant, photoprotective, anti-aging and anti-pigmentary cosmeceutical agents, with a good safety profile. However, the challenge remained to design the stable topical formulation, with such a permeability of L-ascorbic acid as active that the optimal effects on skin could be achieved. The aim of our research was to evaluate the difference between the penetration ability of ascorbyl palmitate incorporated in the same percentage (2%) within the creams and emulgels as carriers, as well as to determine the impact of its incorporation into liposome on the kinetics of penetration. Tape stripping was applied for studying the penetration of the ascorbyl palmitate into the stratum corneum. In addition, the sensory and textural properties of examined formulations were determined. In both cases (liposomal and non-liposomal formulations), creams exhibited a better penetration profile of active substance compared to the use of emulgel. Encapsulation of ascorbyl palmitate into liposomes led to an increase in the adhesiveness and density of the prepared cream and emulgel samples. The best spreadability and absorption during application were detected in liposomal samples. The obtained results confirmed improved dermal penetration of ascorbyl palmitate, either cream or emulgel bases were employed, which further indicates the advantages of its liposomal encapsulation.

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Emulgels- A Novel Approach for Topical Drug Delivery

Cited by 9 publications

References 1 publication

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Novel Cosmeceutical Formulations: A Better Approach to Photoprotection

Enhanced Skin Penetration of Ascorbyl Palmitate Achieved via Liposomal Encapsulation: Tape Stripping Evaluation

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