Emulgel based on amphotericin B and bacuri butter (<i>Platonia insignis</i>Mart.) for the treatment of cutaneous leishmaniasis: characterization and<i>in vitro</i>assays

Coêlho, Elvilene de Sousa; Lopes, Gláucia Laís Nunes; Pinheiro, Iluska Martins; Holanda, Josefa Natália Policarpo de; Alves, Michel Muálem de Moraes; Nogueira, Naiane Carvalho; Carvalho, Fernando Aécio de Amorim; Carvalho, André Luís Menezes

doi:10.1080/03639045.2018.1492610

Cited by 13 publications

(3 citation statements)

References 47 publications

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“…Pereira et al (2019) and dos Santos et al (2013) also reported these two fatty acids as major in studies of the chemical composition of this particular butter. It has since been used as an antioxidant agent in pharmaceutical products (Coêlho et al, 2018) and cosmetics (Costa et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the quality of Amazonian butters as sustainable raw materials for applications in bioproducts

Feitosa

Silva

Fonseca

et al. 2021

Rev. Ciênc. Farm. Básica Apl.

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A new consumer profile for pharmaceutical and cosmetic products has motivated research into natural raw materials in the development of "green" products such as herbal medicines and biocosmetics. However, various limitations have been encountered in the marketing of these products, for example the quality control of the natural raw materials used by the industrial market. This study aims to evaluate the sensory and physicochemical parameters of murumuru (Astrocaryum murumuru Mart.), bacuri (Platonia insignis Mart.), tucuma (Astrocaryum vulgare Mart.), and ucuuba (Virola sebifera Aubl.) butters for applications in pharmaceutical and cosmetic bioproducts. The acidity and saponification as well as the iodine and peroxide indexes were evaluated and fatty acid profiles for the samples obtained by GC-MS. The sensory properties of the butters showed the appearance of solid to soft cream, color (yellow, brown, buttercup, and ochre), and characteristic odor. The melting temperatures of all butters ranged between 31 ºC and 49 °C. The acidity, saponification, iodine and peroxide indexes for the butters were of 5.82-17.73 mg (NaOH or KOH) g −1 , 181.10-573.55 mg KOH g −1 , 2.78-44.96 gl 2 100 g −1 , and 1.39-9.30 meq kg −1 , respectively. From analyses of the fatty acid profiles, the major components identified were lauric acid in murumuru (40%) and ucuuba butters (73%), myristic acid in tucuma butter (53%), and palmitic acid in bacuri butter (42%). In general, the results of the analyses differed from the specifications of the supplier reports and official compendia. These findings highlight the importance of quality control in natural raw materials to ensure their functionality in pharmaceutical and cosmetic bioproducts.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the quality of Amazonian butters as sustainable raw materials for applications in bioproducts

Feitosa

Silva

Fonseca

et al. 2021

Rev. Ciênc. Farm. Básica Apl.

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“…Meanwhile, there are also reports on its combination with other compounds, including natural products like bacuri butter (Coêlho et al, 2018), the antileishmanial drug MLF (Dar et al, 2020a) and novel approaches, such as chitosan platelets (Malli et al, 2019). On the other hand, it should be mentioned that despite not being the drug of first choice for the treatment of CL, there are a large number of scientific reports on its use, possibly due to its simple quantification that allows for more complete in vitro tests, including release profiles and determination of the pharmacokinetics during the development of new formulations.…”

Section: Amphotericin Bmentioning

confidence: 99%

An appraisal of the scientific current situation and new perspectives in the treatment of cutaneous leishmaniasis

et al. 2021

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“…The phytochemical study of the lipid fractions of bacuri seeds and the presence of fatty acids such as palmitic, oleic and linoleic acids were detected, as well as dipertenes and polyprenylated benzophenones, such as garcinielliptone FC (GFC) [9,13,14]. Among the previously reported properties, the antioxidant [15,16], leishmanicidal, immunomodulatory and anti-inflammatory activities [17][18][19] stand out, also presenting vasorelaxant activity induced by GFC, the major constituent of the dried seeds [20]. It is worth mentioning the current work of Lima Nascimento et al [21] on the production and characterization of a β-cyclodextrin inclusion complex with Platonia insignis seed extract as a proposal for a gastroprotective system.…”

Section: Introductionmentioning

confidence: 99%

Solid Lipid Nanoparticles from Platonia insignis Seeds, a Brazilian Amazon Fruit: Characterization, In Vitro and In Vivo Toxicological and Antioxidant Activities

Coêlho,

de Almeida,

Santos

et al. 2023

J. Compos. Sci.

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Solid Lipid Nanoparticles (SLNs) are drug delivery systems with important advantages over conventional nanosystems. Considering previously reported pharmacological and physicochemical properties of Platonia insignis seed butter (BBI), this work aimed at developing, characterizing and performing toxicological and antioxidant studies of SLNs produced from BBI. The GC-MS analysis identified palmitic and oleic acids as the major compounds. Three SLN prototypes were developed through high-shear homogenization followed by ultrasonication. During a 180-day stability evaluation, the formulation SLN/TW-1.5 presented greater stability since pH was around 6.0, as well as a lesser variation of the PdI (Polydispersity Index), particle size and Zeta Potential (ZP), confirmed with Raman Spectroscopy and Atomic Force Microscopy (AFM). The CC50 in macrophages was around 249.4 µg∙mL−1 for BBI, whereas the CC50 value for SLN/TW-1.5 was 45.2 µg∙mL−1. Electron Paramagnetic Resonance (EPR) showed a marked in vitro antioxidant activity for BBI and SLN/TW-1.5. After in vivo SLN/TW-1.5 administration in Zophobas morio larvae, assessment of reduced glutathione (GSH), nitrite (NO2−) and myeloperoxidase (MPO) demonstrated antioxidant activity. Thus, the intrinsic physicochemical properties of BBI allowed the development of an optimized nanoformulation with high stability indexes, besides the great potential for antioxidant applications.

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Emulgel based on amphotericin B and bacuri butter (Platonia insignisMart.) for the treatment of cutaneous leishmaniasis: characterization andin vitroassays

Abstract: It was concluded that the formulations developed showed promising antileishmanial action and high potential for topical use.

Cited by 13 publications

References 47 publications

Evaluation of the quality of Amazonian butters as sustainable raw materials for applications in bioproducts

Evaluation of the quality of Amazonian butters as sustainable raw materials for applications in bioproducts

An appraisal of the scientific current situation and new perspectives in the treatment of cutaneous leishmaniasis

Solid Lipid Nanoparticles from Platonia insignis Seeds, a Brazilian Amazon Fruit: Characterization, In Vitro and In Vivo Toxicological and Antioxidant Activities

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