Emulgel: A dual release system for hydrophobic drug delivery

Kankane, Muskan; Nigam, Vijay; Modi, Shailendra; Jain, Sanjay; Adhikari, Pooja

doi:10.30574/wjbphs.2022.12.3.0258

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…Consequently, emulgels are dual-controlled release systems with numerous preferable characteristics as well as high patient acceptability [ 8 , 9 ]. Emulgels possess numerous favorable properties such as being easily spreadable, easily removable, greaseless, and having a pleasing and transparent appearance [ 10 ]. Compared to other topical and transdermal formulations such as ointments, solutions, and patches, emulsion-based formulations possess better chemical, physical, and biological compatibility with the skin.…”

Section: Introductionmentioning

confidence: 99%

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Milutinov,

Krstonošić,

Ćirin

et al. 2023

Polymers

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Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrier for hydrophobic substances and it determines the occlusive and sensory properties of the product. The emulsifiers are used to promote emulsification during production and to ensure emulsion stability. The choice of emulsifying agents is based on their capacity to emulsify, their toxicity, and their route of administration. Generally, gelling agents are used to increase the consistency of formulation and improve sensory properties by making these systems thixotropic. The gelling agents also impact the release of active substances from the formulation and stability of the system. Therefore, the aim of this review is to gain new insights into emulgel formulations, including the components selection, methods of preparation, and characterization, which are based on recent advances in research studies.

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Section: Introductionmentioning

confidence: 99%

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Milutinov,

Krstonošić,

Ćirin

et al. 2023

Polymers

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“…They also demonstrate enhanced stability compared to emulsions alone. Emulgels represent an exciting new class of delivery vehicles, and this review explores their potential and future prospects [2]. Despite their promise, emulgels have not been extensively reviewed in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…Challenges[2] involved in the formulation and development of emulgel systems are: Difficult emulsification: Emulsification requires high-energy inputs and specialized equipment. It is time consuming and can lead to over-processing damaging heat sensitive compounds.…”

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confidence: 99%

The Expanding Scope of Emulgels: Formulation, Evaluation and Medical Uses

Kumar Sarella,

Pravallika

2023

ijcsrr

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Emulgels are semi-solid emulsions that combine the benefits of both emulsions and gels. They provide enhanced stability, sustained release and improved cosmetic properties. Emulgels can be fabricated using a variety of emulsification techniques and gelling agents like carbopol, hydroxypropyl cellulose. Characterization of emulgels includes evaluation of particle size, viscosity, pH, spreadability and drug release. Emulgels have promising applications in topical delivery of drugs and cosmetics, parenteral delivery of drugs and as emulsion-based oral drug delivery systems. Topical emulgels are used in skin care, hair care and cosmetics to provide moisturization, hydration, etc. Parenteral emulgels can deliver drugs in a sustained manner. Oral emulgels improve the absorption of some drugs. Several advantages of emulgels include sustained and controlled release of actives, improved solubility of both hydrophilic and lipophilic drugs, protection from degradation, and enhanced cosmetic elegance. However, emulgel formulation requires specialized emulsification equipment, and they have lower drug loading capacity compared to other semi-solid systems. Emulgels combine the benefits of emulsions and gels, providing a versatile drug and cosmetic delivery platform with unique advantages. Improvements in emulsification techniques, identifying newer gelling agents and permeation enhancers can further enhance the potential of emulgel systems. With growing research on emulgels, these systems are poised to make a significant impact on topical, parenteral and oral delivery in the coming years. Emulgels thus present an exciting prospect for developing innovative and improved formulations.

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Emulgel: A dual release system for hydrophobic drug delivery

Cited by 2 publications

References 10 publications

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

The Expanding Scope of Emulgels: Formulation, Evaluation and Medical Uses

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