EMT-induced immune evasion: connecting the dots from mechanisms to therapy

Imodoye, Sikiru O.; Adedokun, Kamoru A.

doi:10.1007/s10238-023-01229-4

Cited by 5 publications

(1 citation statement)

References 146 publications

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“…embarked on exploring the potential of combining EMT therapy to overcome resistance to immunotherapy, presenting a promising strategy for enhancing treatment outcomes ( 198 , 199 ). Targeting upstream pathways of EMT can significantly inhibit tumor growth, with TGF-β signaling being the most prominent inducer of EMT ( 200 ). Extensive research has focused on evaluating the effectiveness of TGF-β inhibitors, such as LY2157299, as potent anti-EMT compounds in ongoing clinical trials ( 201 , 202 ).…”

Section: Therapeutic Strategies According To the Mechanisms Of Direct...mentioning

confidence: 99%

Immunocytes interact directly with cancer cells in the tumor microenvironment: one coin with two sides and future perspectives

Ye,

Cheng,

Huang

et al. 2024

Front. Immunol.

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The tumor microenvironment is closely linked to the initiation, promotion, and progression of solid tumors. Among its constitutions, immunologic cells emerge as critical players, facilitating immune evasion and tumor progression. Apart from their indirect impact on anti-tumor immunity, immunocytes directly influence neoplastic cells, either bolstering or impeding tumor advancement. However, current therapeutic modalities aimed at alleviating immunosuppression from regulatory cells on effector immune cell populations may not consistently yield satisfactory results in various solid tumors, such as breast carcinoma, colorectal cancer, etc. Therefore, this review outlines and summarizes the direct, dualistic effects of immunocytes such as T cells, innate lymphoid cells, B cells, eosinophils, and tumor-associated macrophages on tumor cells within the tumor microenvironment. The review also delves into the underlying mechanisms involved and presents the outcomes of clinical trials based on these direct effects, aiming to propose innovative and efficacious therapeutic strategies for addressing solid tumors.

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