Post‐pneumonectomy empyema (PPE), with or without bronchopleural fistula, is a challenging and serious entity with significant mortality and morbidity. PPE is usually caused by bacteria such as staphylococci, streptococci and also gram‐negative rods. Among fungal pathogens,
Aspergillus
species is a very rare cause of this entity. Herein, we describe an unusual case of delayed post‐pneumonectomy empyema necessitans caused by
Aspergillus flavus
in a 65 ‐year‐old man with favourable clinical outcome by combined surgical and antifungal therapy.