Empyema caused by Clostridium sordellii, a rare form of pleuropulmonary disease

Buchman, Alan L.; Ponsillo, Maria; Nagami, Pamela

doi:10.1016/0163-4453(91)91613-3

Cited by 11 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the last decade, several fatal toxic shock syndromes in women were reported that occurred postpartum and after spontaneous or abortion induced with RU‐486 (Bitti et al ., ; Rorbye et al ., ; Sinave et al ., ; Fischer et al ., ; Couzin, ; Winikoff, ; Cohen et al ., ; Soper, ; Agrawal and Garg, ). Sporadic but often fatal cases of C. sordellii infections resulting in bacteraemia, probably subsequent to a bacterial entry from the gastrointestinal tract, pleuropneumonia, arthritis, or after trauma or surgery have been reported (Buchman et al ., ; Abdulla and Yee, ; Gredlein et al ., ; Wiebe et al ., ; Matten et al ., ; Meites et al ., ; Chaudhry et al ., ; Smith and Goslin, ). More rarely, C. sordellii infections can occur as small outbreaks (Aronoff et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Haemorrhagic toxin and lethal toxin fromClostridium sordelliistrain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins

et al. 2014

View full text Add to dashboard Cite

SummaryLarge clostridial glucosylating toxins (LCGTs) are produced by toxigenic strains of Clostridium difficile, Clostridium perfringens, Clostridium novyi and Clostridium sordellii. While most C. sordellii strains solely produce lethal toxin (TcsL), C. sordellii strain VPI9048 co-produces both hemorrhagic toxin (TcsH) and TcsL. Here, the sequences of TcsH-9048 and TcsL-9048 are provided, showing that both toxins retain conserved LCGT features and that TcsL and TcsH are highly related to Toxin A (TcdA) and Toxin B (TcdB) from C. difficile strain VPI10463. The substrate profile of the toxins was investigated with recombinant LCGT transferase domains (rN) and a wide panel of small GTPases. rN-TcsH-9048 and rN-TcdA-10463 glucosylated preferably Rho-GTPases but also Ras-GTPases to some extent. In this respect, rN-TcsH-9048 and rN-TcdA-10463 differ from the respective full-length TcsH-9048 and TcdA-10463, which exclusively glucosylate Rho-GTPases. rNTcsL-9048 and full length TcsL-9048 glucosylate both Rho-and Ras-GTPases, whereas rN-TcdB-10463 and full length TcdB-10463 exclusively glucosylate Rho-GTPases. Vero cells treated with full length TcsH-9048 or TcdA-10463 also showed glucosylation of Ras, albeit to a lower extent than of Rho-GTPases. Thus, in vitro analysis of substrate spectra using recombinant transferase domains corresponding to the auto-proteolytically cleaved domains, predicts more precisely the in vivo substrates than the full length toxins. Except for TcdB-1470, all LCGTs evoked increased expression of the small GTPase RhoB, which exhibited cytoprotective activity in cells treated with TcsL isoforms, but pro-apoptotic activity in cells treated with TcdA, TcdB, and TcsH. All LCGTs induced a rapid dephosphorylation of pY118-paxillin and of pS144/141-PAK1/2 prior to actin filament depolymerization indicating that disassembly of focal adhesions is an early event leading to the disorganization of the actin cytoskeleton.

show abstract

Section: Introductionmentioning

confidence: 99%

Haemorrhagic toxin and lethal toxin fromClostridium sordelliistrain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins

et al. 2014

View full text Add to dashboard Cite

show abstract

“…18 In cattle, C sordelli has been recovered as part of a mixed bacterial population in cases of blackleg and bacillary hemoglobinuria. 18 In humans, C sordelli has been occasionally implicated in soft tissue, bone and joint infections, 19,20 pneumonia and pleuropneumonia, 21 bacteremia, colitis, 22,23 and fulminate endometritis. 24 Previous microbiologic reports from our laboratory showed heavy bacterial growth of C sordelli from an auricular abscess of a sheep, in association with Corynebacter pseudotuberculosis.…”

mentioning

confidence: 99%

Clostridium sordelli Infection as a Suspected Cause of Transient Hyperammonemia in an Adult Horse

Desrochers

Dallap

Wilkins

2003

Veterinary Internal Medicne

View full text Add to dashboard Cite

“…[8][9][10] However, unlike those presenting with myonecrosis or gynaecological infections, where the outcome has been universally fatal, respiratory infections seem to carry a more favourable prognosis. Our 12 year old patient is the first adequately reported case of ear infection as a result of C sordellii.…”

Section: Discussionmentioning

confidence: 99%

The clinical spectrum of Clostridium sordellii bacteraemia: two case reports and a review of the literature

Abdulla

Yee²

2000

Journal of Clinical Pathology

View full text Add to dashboard Cite

Clostridium sordellii is rarely associated with disease in humans. Since its first report in 1922 only a few cases of bacteraemia have been reported. This report describes two cases of C sordellii bacteraemia; the oldest and youngest patients reported to date. The first, is a previously well 81 year old woman presented with perianal infection, which was later complicated by thrombosis of the aorta, and the second is a 12 year old boy with epilepsy who presented with an ear infection. These cases are also highlighted to demonstrate the wide spectrum of presentation of sordellii bacteraemia. (J Clin Pathol 2000;53:709-712)

show abstract

Empyema caused by Clostridium sordellii, a rare form of pleuropulmonary disease

Cited by 11 publications

References 8 publications

Haemorrhagic toxin and lethal toxin fromClostridium sordelliistrain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins

Haemorrhagic toxin and lethal toxin fromClostridium sordelliistrain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins

Clostridium sordelli Infection as a Suspected Cause of Transient Hyperammonemia in an Adult Horse

The clinical spectrum of Clostridium sordellii bacteraemia: two case reports and a review of the literature

Contact Info

Product

Resources

About