The research examined the mental health and well-being of a sample of empty-nesters in Jinan City, Shandong Province, China. An in-depth individual interview approach, with document analysis and participant observation, was performed on three types of interviewees (N = 33) recruited via purposive sampling. The empty-nesters faced many unique problems, especially a sense of being disjointed from the family, community and society. Influencing factors included Chinese traditional filial piety culture, lagging implementation of relevant policies and development of community aging services, as well as the loss of productive roles for the empty nesters. While this paper supports the argument that religious and related social activities play a role in facilitating the psychological adjustment of older people, it reveals a different finding from previous studies that highly educated empty nesters are likely to have lower levels of social participation and psychological fulfillment. Moreover, by employing the social-ecological systems theory for analysis, this study confirms the importance of the family interactions in the life of empty nesters, which contributed to the implication to relevant social policy and social work practice.