“Empty follicle syndrome” after human error: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle

Snaifer, Elie; Hugues, J.-N.; Poncelet, Christophe; Sifer, C.; Pasquier, Maud; Cédrin‐Durnerin, Isabelle

doi:10.1016/j.fertnstert.2007.08.008

Cited by 23 publications

(21 citation statements)

References 25 publications

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“…Attempts to rescue the IVF cycle in case of false EFS have been suggested: readministering hCG and reaspiration [10,15,16,38-40]. A second, rescue dose of hCG in the setting of false EFS was first proposed by Ndukwe et al [15] in 1997, and successful IVF cycles have been reported [38-40].…”

Section: Therapeutic Approachmentioning

confidence: 99%

Empty follicle syndrome

Kim

Jee

2012

Clin Exp Reprod Med

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Empty follicle syndrome (EFS) is a condition in which no oocytes are retrieved after an apparently adequate ovarian response to stimulation and meticulous follicular aspiration. EFS can be classified into 'genuine' and 'false' types according to hCG levels. It is a rare condition of obscure etiology. The existence of genuine EFS has been questioned and is still controversial. The limitation around EFS is that the definition of EFS is obscure. Management of patients with EFS is a challenge to physicians. No single treatment is known to be universally effective. However, patients should be adequately informed regarding the importance of correct hCG administration because improper hCG administration is a common and preventable cause of EFS. EFS is a syndrome that deserves additional study because such investigation could lead to a further understanding of ovarian biology and infertility.

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Section: Therapeutic Approachmentioning

confidence: 99%

Empty follicle syndrome

Kim

Jee

2012

Clin Exp Reprod Med

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“…A second, rescue dose of hCG in the setting of false empty follicle syndrome was first proposed by Ndukwe et al in 1997, and this has persisted as the consensus solution in the literature since that time (1,2,(4)(5)(6). Although isolated case reports have described pregnancies from this approach, the largest single case series portends a limited prognosis (1-6).…”

Section: Discussionmentioning

confidence: 99%

“…A rescue course of hCG with repeat oocyte retrieval of intact follicles 35-37 hours later has been a proposed method of addressing this failure (1). Although some case reports describe successful pregnancies after using this method, a recent larger series of data have suggested a limited prognosis (1)(2)(3)(4)(5)(6).…”

mentioning

confidence: 99%

Rescue human chorionic gonadotropin for false empty follicle syndrome: optimism for successful pregnancy outcome

Doyle

Attaman

Styer

et al. 2012

Fertility and Sterility

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“…Based on several case reports and series, repeat administration of hCG has been recommended when unexpectedly low levels of serum hCG are encountered at the time of failed egg recovery (so called ''false'' empty follicle syndrome [2][3][4][5][6][7]). Given the significant psychologic and financial investment involved in IVF, it has become common practice to administer a second dose of hCG in this setting and to pursue a second retrieval 24-36 hours after the initial failed attempt.…”

mentioning

confidence: 99%

“…Myriad studies have since advocated for a second course of hCG when serum levels are low or undetectable (3)(4)(5)(6)(7). Successful IVF cycles have been reported using embryos transfered either fresh or after cryopreservation, as well as from both GnRH agonist down-regulated cycles and GnRH antagonist cycles (3,5,6). In contrast with the present findings, data extrapolated from a recent literature review indicate that 42.8% of cycles (6 out of 14) in which hCG was readministered in the setting of suboptimal or absent serum hCG resulted in a healthy liveborn fetus (8).…”

mentioning

confidence: 99%