Empowering SARS‐CoV‐2 variant neutralization with a bifunctional antibody engineered with tandem heptad repeat 2 peptides
Ji Woong Kim,
Ji Hyun Lee,
Hyun Jung Kim
et al.
Abstract:With the global pandemic and the continuous mutations of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the need for effective and broadly neutralizing treatments has become increasingly urgent. This study introduces a novel strategy that targets two aspects simultaneously, using bifunctional antibodies to inhibit both the attachment of SARS‐CoV‐2 to host cell membranes and viral fusion. We developed pioneering IgG4‐(HR2)4 bifunctional antibodies by creating immunoglobulin G4‐based and phage dis… Show more
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