Empower Eco multiactor HUB: A triple helix ‘academia-industry-authority’ approach to creating and sharing potentially disruptive tools for addressing novel and emerging new Green Deal opportunities under a United Nations Sustainable Development Goals framework

Rowan, Neil J.; Casey, Orla

doi:10.1016/j.coesh.2021.100254

Cited by 33 publications

(45 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the findings from this research highlight the increasing trend towards the intensive yet sustainable exploitation of bio-based resources from food and marine ecosystems, from the emergence of the bioeconomy 11 . These bio-inspired materials may be refined and scaled up for commercial use through advances in biotechnology, as described here 49 .…”

Section: Discussionmentioning

confidence: 77%

In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications

Usuldin

Wan‐Mohtar

Ilham

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Natural mycelial biomass (MB) and exopolysaccharides (EPS) of Malaysian tiger milk mushroom Lignosus rhinocerus are considered high-end components due to their high commercial potential value in drug discovery. This study aims to evaluate the toxicity of the mushroom extracts’ generated in a bioreactor using the zebrafish embryo toxicity (ZFET) model assay as a new therapy for treating asthma. Both MB and EPS extracts, at concentrations 0.16–10 mg/mL, were tested for ZFET and early development effects on Zebrafish Embryos (ZE) during 24–120 h post-fertilisation (HPF). Findings revealed that MB was deemed safe with an LC50 of 0.77 mg/mL; the EPS were non-toxic (LC50 of 0.41 mg/mL). Neither MB nor EPS delayed hatching nor teratogenic defects in the treated ZE at a 2.5 mg/mL dose. There were no significant changes in the ZE heart rate after treatments with MB (130 beats/min) and EPS (140 beats/min), compared to that of normal ZE (120–180 beats/min). Mixing both natural compounds MB and EPS did not affect toxicity using ZFET testing; thus, intimating their safe future use as therapeutic interventions. This represents the first study to have used the ZFET assay on MB and EPS extracts of L. rhinocerus for future health applications.

show abstract

Section: Discussionmentioning

confidence: 77%

In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications

Usuldin

Wan‐Mohtar

Ilham

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The findings from this research highlight the increasing trend towards the intensive exploiting and sustaining bio-based resources, such as developing food and marine ecosystems including bioeconomy 10 , where these bio-inspired materials may be refined and scaled up for commercial use through advances in biotechnology as described here. Notably, this emerging area will be future-proofed through accelerating digitalization, where metadata outputs will potentially inform food for good, therapeutics, cosmetics, personal care products, smart packaging along with offering putative interventions to help mitigate against Covid-19 disease 9,47,51 .…”

Section: Discussionmentioning

confidence: 77%

“…Mushrooms have become increasingly important as producing organisms in research and industry; food, medicines, cosmetics, detergents and biofuels are examples of high-value products produced by fungi 5,6 . In addition, there has been increased interest in exploiting mushroom-derived extracts as potential solutions for pressing health applications 7,8 , including a focused interest in biorefining these products such as through Green New Deal innovations from food waste streams that attests to enhanced focus on growing 'circularity' and bioeconomy 9,10 . Mushrooms are classified in the kingdom of Fungi and have many active constituents including, but possibly not limited to, polysaccharides, polysaccharide peptides, proteins, terpenoids, and nucleotides 11 .…”

Section: Introductionmentioning

confidence: 99%

In-Vivo Toxicity of Bioreactor-Grown Biomass And Exopolysaccharides From Malaysian Tiger Milk Mushroom Mycelium For Potential Future Health Applications

Usuldin

Wan-Mohtar

Ilham

et al. 2021

Preprint

View full text Add to dashboard Cite

Natural mycelial biomass (MB) and exopolysaccharide (EPS) produced from bioreactor-grown Malaysian Tiger Milk Mushroom Lignosus rhinocerus are considered high-end components due to their high commercial potential value in drug discovery. Both MB (0.16-10 mg/mL) and EPS (0.16-10 mg/mL) extracts were tested for Zebrafish Embryo Toxicity (ZFET) and early development effects on Zebrafish Embryos (ZE) during 24-120 h post-fertilization (HPF) in order to assess toxicity given potential application as a new therapy for treating asthma. Finding revealed that MB was deemed to be safe with an LC50 of 0.77 mg/mL; EPS was shown to be non-toxic (LC50 of 0.41 mg/mL). Neither MB nor EPS delayed hatching nor teratogenic defects in treated ZE at a dose of 2.5 mg/mL. There were no significant changes in the ZE heart rate after MB or EPS treatments with MB (0.16-10 mg/mL: 130 beats/min) and EPS (0.16-10 mg/mL: 140 beats/min), as compared to normal ZE (120-180 beats/min). In addition, mixing of both natural compounds MB and EPS did not affect toxicity using ZFET testing; thus, intimating their safe future use as therapeutic interventions.

show abstract

“…Adaptive resistance to frontline biocides has been reported since the early 1990s such as against bisphenol, triclosan, glutaraldehyde, and oxidising agents [ 22 ]. Paul et al [ 48 ] highlighted that extensive application of biocides affects microbial flora that may lead to decrease in the number and diversity of beneficial microbes that may directly affect the functioning of nutrient cycles; thus, careful considerations should be given to biocide neutralization, environmental management and sustainability [ 50 , 51 ]. Understanding these factors is important for training of end-users, (e.g, healthcare, industry and community), to ensure efficacy of biocidal product is maintained and effectively neutralised, along with monitoring policy for effective and responsible deployment of biocides.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of frontline chemical biocides and disinfection approaches for inactivating SARS-CoV-2 variants of concern that cause coronavirus disease with the emergence of opportunities for green eco-solutions

Rowan

Meade

Garvey

2021

Current Opinion in Environmental Science & Health

Self Cite

View full text Add to dashboard Cite

The emergence of severe acute respiratory disease (SARS-CoV-2) variants that causes coronavirus disease (COVID-19) is of global concern. SARS-Cov-2 variants of concern (VOC) exhibiting greater transmissibility, and potentially increased risk of hospitalization, severity and mortality, are attributed to molecular mutations in outer viral surface spike proteins. Thus, there is a reliance on using appropriate counter-disease measures including non-pharmaceutical interventions and vaccination. Best evidence suggests that use of frontline biocides effectively inactivate coronavirus similarly, including VOC, such as 202012/01, 501Y.V2 and P.1 that have rapidly replaced the wild-type variant in the United Kingdom, South Africa and Brazil, respectively. However, this review highlights that efficacy of VOC-disinfection will depend on type of biocide and parameters governing activity. VOC are likely to be similar in size to the wild-type strain, thus implying that existing guidelines for use and re-use of face masks post disinfection remain relevant. Monitoring to avoid injudicious use of biocides during COVID-19 era is required as prolonged and excessive biocide usage may negatively impact our receiving environments; thus, highlighting the potential for alternative more environmental-friendly sustainable biocide solutions. Traditional biocides may promote cross-antimicrobial resistance (AMR) to antibiotics in problematical bacteria. Existing filtration efficacy of face masks is likely to perform similarly for VOC due to similar viral size; however, advances in face mask manufacturing by way incorporating new anti-viral materials will potentially enhance their design and functionality for existing and potentially future pandemics.

show abstract

Empower Eco multiactor HUB: A triple helix ‘academia-industry-authority’ approach to creating and sharing potentially disruptive tools for addressing novel and emerging new Green Deal opportunities under a United Nations Sustainable Development Goals framework

Cited by 33 publications

References 26 publications

In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications

In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications

In-Vivo Toxicity of Bioreactor-Grown Biomass And Exopolysaccharides From Malaysian Tiger Milk Mushroom Mycelium For Potential Future Health Applications

Efficacy of frontline chemical biocides and disinfection approaches for inactivating SARS-CoV-2 variants of concern that cause coronavirus disease with the emergence of opportunities for green eco-solutions

Contact Info

Product

Resources

About