Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance

Zhang, Mengsi; Wang, Lu; Jiang, Hao; Zhao, Nan; Liu, Yi; Lan, Shou‐Jen; Liu, Shuwei; Zhang, Hao

doi:10.1016/j.jconrel.2023.05.020

Cited by 8 publications

(7 citation statements)

References 47 publications

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“…This matches well with the β-FeOOH pattern (JCPDS no. 75-1594), , indicating that β-FeOOH nanorods grew on the coating of PP-Fe and C2K1-Fe. This result corresponds to SEM and ATR-FTIR.…”

Section: Results and Discussionmentioning

confidence: 99%

Iron-Based Oxides Anchored on the Catechol/Silane-Coated Polypropylene Nonwoven Fabrics for Effective Removal of Anionic Dyes

Li,

Sun,

Yang

et al. 2024

ACS Appl. Polym. Mater.

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The dopamine modification strategy has received extensive attention in water treatment due to its simple and gentle preparation process, excellent adhesion, and good secondary reactivity. Further research has found that compounds containing the catechol groups can react with the amino-containing silane coupling agents under mild conditions to form dopamine-like hydrophilic coatings on the surface of hydrophobic membranes or fibers. This paper used cheap polypropylene melt-blown nonwovens as the substrate to prepare a large-capacity dye adsorbent PP-(CK-Fe). Specifically, catechol (CA) and (3-aminopropyl) triethoxysilane (KH550) were used to form a codeposited coating on the substrate. Then, we used the secondary reactivity of the coating to grow iron-based oxides in situ. The adsorbent had good adsorption performance on anionic dyes at the initial pH of the dye solution, including Orange II (380 mg/g), methyl orange (268 mg/g), Congo red (294 mg/g), and carmine (263 mg/g). However, it had almost no adsorption effect on cationic dyes at the initial pH, including methylene blue and Rhodamine B. We chose Orange II to explore the possible adsorption mechanism. The results confirmed that the adsorbent had good adsorption performance at pH 3−11. The adsorption process tended to be monolayer chemical adsorption. The maximum adsorption capacity (Q max ) of Orange II was 515.46 mg/g under optimal conditions. This study also confirmed that the codeposition coating constructed with polyphenol and amino-containing silane coupling agents had a secondary reactivity similar to the dopamine coating.

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“…This matches well with the β-FeOOH pattern (JCPDS no. 75-1594), , indicating that β-FeOOH nanorods grew on the coating of PP-Fe and C2K1-Fe. This result corresponds to SEM and ATR-FTIR.…”

Section: Results and Discussionmentioning

confidence: 99%

Iron-Based Oxides Anchored on the Catechol/Silane-Coated Polypropylene Nonwoven Fabrics for Effective Removal of Anionic Dyes

Li,

Sun,

Yang

et al. 2024

ACS Appl. Polym. Mater.

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“…In the MOF structure, coordination bonds play a supporting role as a skeleton, and the loading of chemotherapy drugs in MOF is through physical adhesion or hydrogen bonding, π–π interaction, etc. − The above-mentioned supramolecular weak interaction is not as stable as a covalent bond, which provides a possibility for the responsive disintegration of the MOF structure and the responsive release of chemotherapy drugs. In addition, ferroptosis-related research has developed rapidly in recent years, and has been well applied in the field of tumor therapy. − Ferroptosis is an iron-dependent programmed cell death involving intracellular iron accumulation, oxidation–reduction (REDOX) imbalance, and lipid peroxidation. − Using iron-containing MOF as a chemotherapy drug carrier is also expected to take advantage of the interaction between iron ions and tumor microenvironment (TME) components, resulting in excessive accumulation of lipid peroxides (LPO) and reactive oxygen species (ROS), resulting in a new therapeutic function of ferroptosis.…”

Section: Introductionmentioning

confidence: 99%

Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy–Ferroptosis Combined Therapy for Gastric Cancer

Sun,

Zheng,

Zhang

et al. 2024

ACS Omega

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Oxaliplatin (Oxa) is a commonly used chemotherapy drug in the treatment of gastric cancer, but its toxic side effects and drug resistance after long-term use have seriously limited its efficacy. Loading chemotherapy drugs with nanomaterials and delivering them to the tumor site are common ways to overcome the above problems. However, nanomaterials as carriers do not have therapeutic functions on their own, and the effect of single chemotherapy is relatively limited, so there is still room for progress in related research. Herein, we construct Oxa@Mil-100(Fe) nanocomposites by loading Oxa with a metal−organic framework (MOF) Mil-100(Fe) with high biocompatibility and a large specific surface area. The pore structure of Mil-100(Fe) is conducive to a large amount of Oxa loading with a drug-loading rate of up to 27.2%. Oxa@Mil-100(Fe) is responsive to the tumor microenvironment (TME) and can release Oxa and Fe 3+ under external stimulation. On the one hand, Oxa can inhibit the synthesis of DNA and induce the apoptosis of gastric cancer cells. On the other hand, Fe 3+ can clear overexpressed glutathione (GSH) in TME and be reduced to Fe 2+ , inhibiting the activity of glutathione peroxidase 4 (GPX4), leading to the accumulation of intracellular lipid peroxides (LPO), and at the same time releasing a large number of reactive oxygen species (ROS) through the Fenton reaction, inducing ferroptosis in gastric cancer cells. With the combination of apoptosis and ferroptosis, Oxa@Mil-100(Fe) shows a good therapeutic effect, and the killing effect on gastric cancer cells is obvious. In a nude mouse model of subcutaneous tumor transplantation, Oxa@Mil-100(Fe) shows a significant inhibitory effect on tumor growth, with an inhibition rate of nearly 60%. In addition to its excellent antitumor activity, Oxa@Mil-100(Fe) has no obvious toxic or side effects. This study provides a new idea and method for the combined treatment of gastric cancer.

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“…Moreover, in previous reports, EGCG could reduce the cellular thermal resistance for tumor ablation in deeper tissue . Due to their single-step formation, excellent biosafety, and easy functionalization, polyphenol-metal networks have aroused a lot of recent interest in nanomedicine-related sectors. , Based on these findings, polyphenol-metal networks formed by multivalent metal ions Fe 3+ and EGCG were selected as tumor-targeting ligands.…”

Section: Introductionmentioning

confidence: 99%

Amplification of Oxygen-Independent Free Radicals Based on a Glutathione Depletion and Biosynthesis Inhibition Strategy for Photothermal and Thermodynamic Therapy of Hypoxic Tumors

Huang,

Li,

Zhao

et al. 2024

ACS Appl. Mater. Interfaces

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Thermodynamic therapy (TDT) based on oxygen-independent free radicals exhibits promising potential for the treatment of hypoxic tumors. However, its therapeutic efficacy is seriously limited by the premature release of the drug and the free radical scavenging effect of glutathione (GSH) in tumors. Herein, we report a GSH depletion and biosynthesis inhibition strategy using EGCG/Fe-camouflaged gold nanorod core/ZIF-8 shell nanoparticles embedded with azo initiator 2,2′-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) and L-buthionine-sulfoximine (BSO) for tumor-targeting photothermal (PTT) and thermodynamic therapy (TDT). This nanoplatform (GNR@ZIF-8-AIPH/BSO@EGCG/Fe, GZABEF) endows a pH-responsive release performance. With the 67 kDa lamin receptor (67LR)-targeting ability of EGCG, GZABEF could selectively release oxygen-independent free radicals in tumor cells under 1064 nm laser irradiation. More importantly, Fe3+-mediated GSH depletion and BSO-mediated GSH biosynthesis inhibition significantly boosted the accumulation of alkyl radicals. In 4T1 cells, GZABEF induced cancer cell death via intracellular GSH depletion and GSH peroxidase 4 (GPX4) inactivation. In a subcutaneous xenograft model of 4T1, GZABEF demonstrated remarkable tumor growth inhibition (78.2%). In addition, excellent biosafety and biocompatibility of GZABEF were observed both in vitro and in vivo. This study provides inspiration for amplified TDT/PTT-mediated antitumor efficacy.

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Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance

Cited by 8 publications

References 47 publications

Iron-Based Oxides Anchored on the Catechol/Silane-Coated Polypropylene Nonwoven Fabrics for Effective Removal of Anionic Dyes

Iron-Based Oxides Anchored on the Catechol/Silane-Coated Polypropylene Nonwoven Fabrics for Effective Removal of Anionic Dyes

Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy–Ferroptosis Combined Therapy for Gastric Cancer

Amplification of Oxygen-Independent Free Radicals Based on a Glutathione Depletion and Biosynthesis Inhibition Strategy for Photothermal and Thermodynamic Therapy of Hypoxic Tumors

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