With large number of participants, tight development time, high technical standards, there is great uncertainty and risk during doing researching on Unmanned Aerial Vehicle (UAV for short). This article makes a count on the accidents’ data of the past 30 years and analyses the causes of these accidents, thus creating the comprehensive risk evaluation index system of the research on UAV. Based on analytic hierarchy process, the paper builds comprehensive Risk Assessment model and discusses the Risk Response System during the research on UAV to guide specific practices of Risk Management of UAV project.