Employing gadolinium micro-disks as temperature probes for magnetic resonance imaging

Nobles, Jason E.; Hao, Y.; Goldman, S.; Stroud, John; Stupic, Karl F.; Hankiewicz, J; Celinski, Zbigniew

doi:10.1016/j.jmmm.2022.169849

Cited by 2 publications

(4 citation statements)

References 70 publications

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“…That is, the loss of phase coherence among nuclear spins happens faster than the diffusion responsible for the spin phase averaging. Note that this is similar to situations where there is fast diffusion, but the particle sizes are on the order of micrometers [ 53 ].…”

Section: Resultsmentioning

confidence: 73%

Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications

Stoll

Lachowicz

Kmita

et al. 2023

IJMS

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The aim of this project is to fabricate hydrogen-rich silicone doped with magnetic nanoparticles for use as a temperature change indicator in magnetic resonance imaging-guided (MRIg) thermal ablations. To avoid clustering, the particles of mixed MnZn ferrite were synthesized directly in a medical-grade silicone polymer solution. The particles were characterized by transmission electron microscopy, powder X-ray diffraction, soft X-ray absorption spectroscopy, vibrating sample magnetometry, temperature-dependent nuclear magnetic resonance relaxometry (20 °C to 60 °C, at 3.0 T), and magnetic resonance imaging (at 3.0 T). Synthesized nanoparticles were the size of 4.4 nm ± 2.1 nm and exhibited superparamagnetic behavior. Bulk silicone material showed a good shape stability within the study’s temperature range. Embedded nanoparticles did not influence spin–lattice relaxation, but they shorten the longer component of spin–spin nuclear relaxation times of silicone’s protons. However, these protons exhibited an extremely high r2* relaxivity (above 1200 L s−1 mmol−1) due to the presence of particles, with a moderate decrease in the magnetization with temperature. With an increased temperature decrease of r2*, this ferro–silicone can be potentially used as a temperature indicator in high-temperature MRIg ablations (40 °C to 60 °C).

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Section: Resultsmentioning

confidence: 73%

Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications

Stoll

Lachowicz

Kmita

et al. 2023

IJMS

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“…The proposed method of temperature determination using temperature-dependent intensity of T 1 , T 2 and T * 2 -weighted MR images suffers inherently from two major issues. As we have shown in our earlier work, the nuclear relaxation of water protons in the presence of magnetic particles strongly depends on magnetic field magnitude and particle concentration [51,52]. While the magnetic field of the MR scanner is well determined and does not change, the concentration of particles injected into the blood arteries will vary in space and time.…”

Section: Limitations Of Thermometry Using Mri Temperature-sensitive C...mentioning

confidence: 76%

“…As we have shown in our earlier work, the nuclear relaxation of water protons in the pr ence of magnetic particles strongly depends on magnetic field magnitude and parti concentration [51,52]. While the magnetic field of the MR scanner is well determined a does not change, the concentration of particles injected into the blood arteries will vary space and time.…”

Section: Limitations Of Thermometry Using Mri Temperature-sensitive C...mentioning

confidence: 80%

“…While the magnetic field of the MR scanner is well determined and does not change, the concentration of particles injected into the blood arteries will vary in space and time. This challenge can be partially mitigated by using particle-doped polymer filaments or patches and inserted into or placed on the region of interest, as proposed in our recent papers [51,53]. The calibration of the temperature-dependent image intensity of such ferro-polymers can be conducted prior to their use.…”

Section: Limitations Of Thermometry Using Mri Temperature-sensitive C...mentioning

confidence: 99%

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Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent

Lachowicz,

Kmita,

Gajewska

et al. 2023

IJMS

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Mixed manganese–zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 °C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg/mL of Fe, the spin–spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal/spatial resolution of 3.2 °C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.

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Employing gadolinium micro-disks as temperature probes for magnetic resonance imaging

Cited by 2 publications

References 70 publications

Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications

Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications

Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent

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