Employ FTIR spectroscopic method for determination of certain multiple sclerosis medications in plasma and pharmaceutical formulations

Oraby, Mohamed; Ahmed, Ahmed; Abdel‐Lateef, Mohamed A.; Mostafa, Mohamed H.; Hassan, Ahmed I.

doi:10.1016/j.microc.2021.106329

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…The content uniformity (CU) test for BIL in tablet formulation was performed in accordance with USP requirements (Chap. 905) [22]. A separate analysis of 10 Contrahistadin ® 20 mg tablets was used for testing the uniformity of their contents using the procedure described under the analysis of pharmaceutical tablets for each individual tablet.…”

Section: Procedures For Content Uniformity Testmentioning

confidence: 99%

“…the proportion of active elements in the tablet formulation does not go beyond 25% of the entire weight of the tablet or if the content of the active constituent is less than 25 mg, it is advised that the CU of the tablet units should be investigated [22,25,26]. For the rst time, the spectro uorometric method was utilized to track the CU of BIL in commercial tablets.…”

Section: Application To Content Uniformity (Cu) Testmentioning

confidence: 99%

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A green spectrofluorimetric approach for the versatile determination of Bilastine in real human plasma and pharmaceutical preparations with content uniformity testing

Derayea

El‐Din

Ahmed

et al. 2022

Preprint

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A green spectrofluorimetric method for determining Bilastine (BIL) was described. The method is very sensitive, simple, and quick. The suggested method was depend on the measurement of the original fluorescence of BIL in 1.0 M sulfuric acid at an emission wavelength of 385 nm after an excitation at 272 nm. The method was evaluated by ICH requirements. The relationship between BIL concentrations and the fluorescence intensities was linear in a range of 10.0–500.0 ng mL− 1, and the correlation coefficient was 0.9999. The detection limit was 2.9 ng mL− 1 and quantitation limit was 8.8 ng mL− 1. The suitable sensitivity and selectivity of the suggested method enabled its application successfully in analyzing BIL in real human plasma with appropriate recoveries from 95.72% to 97.2 %, as well as in pharmaceutical preparations without any interfering effect from plasma components or pharmaceutical excipients. Additionally, the suggested method was utilized efficiently for content uniformity test.

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Section: Procedures For Content Uniformity Testmentioning

confidence: 99%

Section: Application To Content Uniformity (Cu) Testmentioning

confidence: 99%