Empirical validation of ProteinMPNN’s efficiency in enhancing protein fitness
Tianshu Wang,
Xiaocheng Jin,
Xiaoli Lu
et al.
Abstract:Introduction: Protein engineering, which aims to improve the properties and functions of proteins, holds great research significance and application value. However, current models that predict the effects of amino acid substitutions often perform poorly when evaluated for precision. Recent research has shown that ProteinMPNN, a large-scale pre-training sequence design model based on protein structure, performs exceptionally well. It is capable of designing mutants with structures similar to the original protei… Show more
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