Empirical treatment of outpatients with gastroesophageal reflux disease with proton pump inhibitors: A survey of Chinese patients (the ENLIGHT Study)

Lü, Bin; Zhang, Ling; Wang, Jiangbin; Wang, Bangmao; Zou, Xiaoping; Fei, Guijun; Chen, Dongfeng; Wang, Xuehong; Wu, Bin; Zou, Duowu

doi:10.1111/jgh.14143

Cited by 2 publications

(3 citation statements)

References 18 publications

(28 reference statements)

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“…The combination of omeprazole (20 mg/day) and baclofen showed high improvement in burning and reflux (34). Lu et al (49) reported that 71.7% of patients responded to PPIs, similar to what we observed in group A. Our data analysis showed that the intervention with omeprazole (A group) made statistically significant improvements by 73.68%, 66.66%, 66.66%, and 90% in the FFSG, RS, VAS, and GERD-HRQL scores, respectively.…”

Section: Discussionsupporting

confidence: 88%

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Sadeghi

Fazljou

Sepehri

et al. 2020

Iran Red Crescent Med J

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Background: The cardinal symptoms of gastroesophageal reflux disease include heartburn (pyrosis) and regurgitation. Conventional treatment is done by proton pump inhibitors. In Persian traditional medicine, several herbs (single or combined) have been used to treat gastrointestinal disorders. Objectives: This study aimed to assess the effects of Pistacia lentiscus (mastic) and Coriander Triphala on reflux symptoms compared to omeprazole in a double-blinded randomized clinical trial. Methods: In a double-blinded, multicenter, randomized clinical trial, we assessed the effects of Pistacia lentiscus L., Coriander Triphala, and omeprazole on the symptoms of GERD in Tabriz, Iran, in 2018 - 2019. Thus, 105 patients with GERD symptoms were assigned randomly to three groups as group A (Pistacia lentiscus L., 1000 mg/TDS), group B (Coriander Triphala, 1000 mg/TDS), and group C (omeprazole, 20 mg/day plus five placebo capsules per day). The assessments were done at the beginning and the end of the study using FSSG, VAS, RS, and GERD-HRQL questionnaires. Results: In the beginning, no significant differences were observed between the groups in the background characteristics. There was no statistically significant difference between Pistacia lentiscus, Coriander Triphala, and omeprazole in the improvement of FSSG, VAS, GERD-HRQL, and reflux scores. In all groups, the FFSG, VAS, reflux, and GERD-HRQL scores significantly decreased and improved after four weeks of intervention compared to the respective baselines. The FSSG score improvements after four weeks of intervention were 73.68%, 83.33%, and 68.62%, in groups A, B, and C, respectively. The VAS score improvements were 66.66%, 75.00%, and 62.50% in groups A, B, and C, respectively. Improvements in GERD-HRQL were 90.00%, 91.28%, and 82.00%, in groups A, B, and C, respectively. Reflux improvements were 66.66%, 80.00%, and 66.66% in groups A, B, and C, respectively. Conclusions: The results showed that Pistacia lentiscus and Coriander Triphala are as effective as omeprazole in the treatment of GERD.

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Section: Discussionsupporting

confidence: 88%

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Sadeghi

Fazljou

Sepehri

et al. 2020

Iran Red Crescent Med J

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“… 18 In these patients, empiric therapy was successful in up to 71.1% of patients reporting classic reflux symptoms. 19 In our patient population, heartburn and regurgitation were two of the three most commonly noted symptoms used to describe symptoms associated with reflux and indicates a known association between these particular symptoms and the diagnosis of GERD. Patients with these symptoms of a very common disease entity are likely to present to a provider with typical symptoms of reflux and receive a treatment that is overall efficacious in reducing their symptoms.…”

Section: Discussionmentioning

confidence: 67%

“…Heartburn and regurgitation are reportedly the most reliable symptoms for making a presumptive diagnosis of erosive esophagitis with sensitivity and specificity ranging from 30% to 76% and 62% to 96% specificity 18 . In these patients, empiric therapy was successful in up to 71.1% of patients reporting classic reflux symptoms 19 . In our patient population, heartburn and regurgitation were two of the three most commonly noted symptoms used to describe symptoms associated with reflux and indicates a known association between these particular symptoms and the diagnosis of GERD.…”

Section: Discussionmentioning

confidence: 99%

Layperson Perception of Reflux‐Related Symptoms

et al. 2023

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Objective To assess for differences of intended meaning in the description of reflux‐related symptoms among otolaryngology patients and clinicians. Study Design Cross‐sectional survey‐based study. Setting Five tertiary, academic otolaryngology practices. Methods Between June 2020 and July 2022, a questionnaire consisting of 20 common descriptors of reflux‐related symptoms within four domains (throat‐, chest‐, stomach‐, and sensory‐related symptoms) was completed by patients. Attending otolaryngologists at five academic medical centers then completed the same survey. The primary outcome was to assess differences in patient and clinician perceptions of reflux‐related symptoms. Differences based on geographic location was a secondary outcome. Results A total of 324 patients and 27 otolaryngologists participated. Patients selected a median of six terms compared with 10.5 for otolaryngologists ( p < .001). Otolaryngologists were more likely to select sensory symptoms (difference: 35.8%; 95% confidence interval [CI]: 19.2%, 52.4%), throat‐related symptoms (32.4%; 21.2, 43.6%), and chest‐related symptoms (12.4%; 8.8, 15.9). Otolaryngologists and patients were equally likely to consider stomach symptoms as related to reflux (4.0%, −3.7%, 11.7%). No significant differences were identified based on geographic location. Conclusion There are differences between otolaryngologists and their patients in the interpretation of the symptoms of reflux. Patients tended to have a narrower interpretation of reflux with symptoms primarily limited to classic stomach‐related symptoms, while clinicians tended to have a broader definition of reflux that included extra‐esophageal manifestations of disease. This has important counseling implications for the clinician, as patients presenting with reflux symptoms may not comprehend the relationship of those symptoms to reflux disease.

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Empirical treatment of outpatients with gastroesophageal reflux disease with proton pump inhibitors: A survey of Chinese patients (the ENLIGHT Study)

Abstract: Short-term empirical PPI treatment can provide an effective relief of GERD symptoms in most Chinese patients in real-world practice.

Cited by 2 publications

References 18 publications

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Layperson Perception of Reflux‐Related Symptoms

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