Empirical Analysis of Drug Targets for Nervous System Disorders
Louis G. Mueller,
Barbara S. Slusher,
Takashi Tsukamoto
Abstract:The discovery and development of drugs to treat diseases of the nervous system remains challenging. There is a higher attrition rate in the clinical stage for nervous system experimental drugs compared to other disease areas. In the preclinical stage, additional challenges arise from the considerable effort required to find molecules that penetrate the blood−brain barrier (BBB) coupled with the poor predictive value of many preclinical models of nervous system diseases. In the era of targetbased drug discovery… Show more
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