Emphysema on imaging is associated with quality of life in elderly patients with chronic obstructive pulmonary disease

Motohashi, Norihisa; Kimura, Kazuyoshi; Ishii, Takeo; Wakabayashi, Ritsuko; Kurosaki, Hiroko; Motegi, Takashi; Yamada, Kazutoyo; Jones, Rupert; Gemma, Akihiko; Kida, Kenji

doi:10.1111/j.1447-0594.2009.00549.x

Cited by 11 publications

(9 citation statements)

References 34 publications

(57 reference statements)

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“…The percentage of low-attenuation area (LAA%) in high-resolution CT (HRCT) images was calculated as described previously 23. HRCT was performed using a LightSpeed Pro16 CT scanner (General Electric Co, Tokyo, Japan) with the following settings: 1.25-mm collimation, 0.8-second scan time (rotation time), 120 kV, and 100–600 mA.…”

Section: Methodsmentioning

confidence: 99%

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease

Furutate¹,

Ishii²,

Wakabayashi³

et al. 2011

COPD

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Background:Previous studies have suggested links between chronic obstructive pulmonary disease (COPD), cardiovascular disease, and abdominal obesity. Although abdominal visceral fat is thought to be associated with cardiovascular risk factors, the degree of visceral fat accumulation in patients with COPD has not been directly studied. The aim of this study was to investigate the abdominal visceral fat accumulation and the association between visceral fat and the severity and changes in emphysema in COPD patients.Methods:We performed clinical and laboratory tests, including pulmonary function, dyspnea score, and the six-minute walking test in COPD patients (n = 101) and control, which included subjects with a smoking history but without airflow obstruction (n = 62). We used computed tomography to evaluate the abdominal visceral fat area (VFA), subcutaneous fat area (SFA), and the extent of emphysema.Results:The COPD group had a larger VFA than the control group. The prevalence of non-obese subjects with an increased VFA was greater in the Global Initiative for Chronic Obstructive Lung Disease Stages III and IV than in the other stages of COPD. The extent of emphysema was inversely correlated with waist circumference and SFA. However, VFA did not decrease with the severity of emphysema. VFA was positively correlated with the degree of dyspnea.Conclusion:COPD patients have excessive visceral fat, which is retained in patients with more advanced stages of COPD or severe emphysema despite the absence of obesity.

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Section: Methodsmentioning

confidence: 99%

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease

Furutate¹,

Ishii²,

Wakabayashi³

et al. 2011

COPD

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“…17 High-resolution computed tomography (HRCT) of the chest Emphysema severity and airway remodelling were determined on the basis of HRCT scans obtained at full inspiration, as in our previous study. 18 Helical computed tomography scans were acquired with a 1.25-mm collimation, a scan time (rotation time) of 0.8 s, 120 kV and 100B600 mA, using a Light Speed Pro16 computed tomography scanner (GE, Tokyo, Japan).…”

Section: Pulmonary Function Testingmentioning

confidence: 99%

Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms

et al. 2010

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A serotonin transporter gene, SLC6A4, is thought to be related to nicotine dependence and depression, one of the comorbidities of chronic obstructive pulmonary disease (COPD). To investigate the association between SLC6A4 variation and tobacco consumption, susceptibility to COPD, and depression status. In all, 247 patients with COPD and 119 control subjects were genotyped for 5 tag single-nucleotide polymorphisms (SNPs) of SLC6A4. We analyzed the correlation between these genotypes and COPD, using the results of a pulmonary function test or chest computed tomography; data on tobacco consumption (packyears); and the depression score based on the hospital anxiety and depression scale (HADS) after adjusting for age, gender, and smoking status (and pack-years, when appropriate). The rare allele rs2020936 was significantly associated with COPD incidence in the trend model (P¼0.003; odds ratio, 2.20; 95% confidence interval, 1.31-3.74). This allele was also associated with the number of pack-years (P¼0.026). The major allele of another SNP of SLC6A4, namely rs3794808, correlated with the HADS depression score (P¼0.016). We conclude that SLC6A4 variation affects COPD pathogenesis, and this effect depends partly on tobacco consumption. SLC6A4 variation also affects depressive symptoms. SLC6A4 could be modified to prevent COPD and treat the depressive symptoms of COPD.

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“…The percentage of low attenuation area in the upper lung field (LAA%-U), reflecting the severity of emphysema, was calculated as described previously [31,32].…”

Section: High-resolution Computed Tomography (Hrct)mentioning

confidence: 99%

Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease

Ito

Oka

Ishii

et al. 2015

Journal of Proteomics

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Emphysema on imaging is associated with quality of life in elderly patients with chronic obstructive pulmonary disease

Cited by 11 publications

References 34 publications

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease

Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms

Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease

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