Empfehlungen der Arbeitsgruppe „Photopatchtest“ der Deutschen Kontaktallergie‐Gruppe (DKG) zur Durchführung des Photopatchtests

Geier, Johannes; Bauer, Andrea; Becker, Detlef; Breit, Reinhard; Hofmann, Silke; Kapp, Alexander; Lehmann, Percy; Mahler, Vera; Molin, Sonja

doi:10.1111/ddg.13683_g

Cited by 9 publications

(7 citation statements)

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“…The irradiated area is examined before and immediately after irradiation (that is, 24 hours after application of the test substances), as well as after 48 and 72 hours. After 24 and 48 hours, respectively, the test block of the non-irradiated tests is also removed and the test reactions in the non-irradiated area are examined for the same time intervals [49][50][51]. The observation of the reaction over a period of 72 hours facilitates the differentiation between phototoxic and photoallergic reaction: the latter is characterized by a delayed onset with a crescendo pattern -apart from erythema and infiltrate, papulovesicles, blisters, or erosions are common.…”

Section: Additional In Vivo Test Methodsmentioning

confidence: 99%

“…Causal factors are contact to contact allergens (haptens) in allergic contact dermatitis, contact to photoallergens in combination with exposure to ultraviolet (UV) radiation in photoallergic contact dermatitis, contact to chromophore-containing substances together with UV radiation in phototoxic contact dermatitis, and contact to proteins in protein contact dermatitis. Tables 1 and 3 provide an overview of the different forms of contact dermatitis, their triggers, and the indicative diagnostic workup [11,[49][50][51][52][53][54][55]. The frequent occurrence of multifactorial contact eczemas (especially on the hands) has been emphasized repeatedly [2,56].…”

Section: History In Case Of Suspected Contact Dermatitismentioning

confidence: 99%

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German S1 guideline: Contact dermatitis

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

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Summary Contact dermatitis is an inflammation of the epidermis and dermis at the site of exposure triggered by external agents. The two main forms are irritant and allergic contact dermatitis, which cause significant health and socioeconomic costs in addition to a marked reduction in quality of life. The anamnesis and the clinical picture are decisive for the necessary diagnostic measures. The most accurate possible diagnostic classification of contact dermatitis by means of allergological testing is important for disease management, since not only classical eczema therapy but also avoidance of the exogenous triggering factors are of great importance here. The choice of therapy should be based on the acuity, clinical severity, morphology of the lesions and localization of the contact dermatitis. A combination of basic therapy, topical, physical, and systemic therapy adapted to the patient’s needs is required, whereby not all forms of therapy must be carried out simultaneously but can be used in a varying manner. Primary, secondary, and tertiary prevention strategies aim at the recognition of the triggering noxae or allergens with subsequent contact avoidance or minimization. The present S1‐guideline on contact dermatitis is primarily intended to provide dermatologists, allergologists and physicians working in allergology and occupational dermatology with a decision‐making aid for the selection and implementation of suitable and sufficient diagnostics, therapy, and prevention.

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Section: Additional In Vivo Test Methodsmentioning

confidence: 99%

Section: History In Case Of Suspected Contact Dermatitismentioning

confidence: 99%

German S1 guideline: Contact dermatitis

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

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“…Again, there was no evidence for lymphoma or other conditions on bone marrow biopsy. Patch-testing including the photopatch test (5 J/cm 2 UV-A; PUVA 180, Waldmann, Villingen-Schwenningen, Germany) did not reveal evidence for airborne contact dermatitis or photocontact allergy [8]. However, the entire test areal on the lower back showed erythema with eczematous changes following the next days.…”

Section: Case Presentationmentioning

confidence: 98%

Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid

Gambichler

Patsinakidis

Susok

et al. 2020

Case Reports in Dermatological Medicine

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Actinic reticuloid (AR)—a subtype of chronic actinic dermatitis—clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, histopathology, and phototesting were consistent with AR. The patient was treated with cyclosporine 150–300 mg/d. Under this therapy, he developed several times primary cutaneous anaplastic large cell lymphomas (C-ALCL) which in part tended to regress spontaneously under cyclosporine reduction. The association between cyclosporine treatment and development of C-ALCL and other CD30+ lymphoproliferative disorders has previously been reported in patients with atopic dermatitis, psoriasis, and transplant patients. In conclusion, the present case highlights the difficulties arising in the distinction between AR and CTCL and shows that long-term cyclosporine treatment may cause C-ALCL development in AR as well.

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“…If required, other, less standardized procedures, such as open, semi‐open, or photo patch test, may be helpful to exclude contact allergy. These tests should be performed in experienced centers 44,49,54,55 …”

Section: Recommendationsmentioning

confidence: 99%

S2k guideline diagnosis, prevention, and therapy of hand eczema

Bauer,

Brans,

Brehler

et al. 2023

J Deutsche Derma Gesell

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SummaryThe consensus‐based guideline “Diagnosis, prevention, and treatment of hand eczema (HE)” provides concrete instructions and recommendations for diagnosis, prevention, and therapy of HE based on an evidence‐ and consensus‐based approach. The guideline was created based on the German guideline “Management von Handekzemen” from 2009 and the current guideline of the European Society of Contact Dermatitis (ESCD) “Guidelines for diagnosis, prevention, and treatment of hand eczema” from 2022. The general goal of the guideline is to provide dermatologists and allergologists in practice and clinics with an accepted, evidence‐based decision‐making tool for selecting and conducting suitable and sufficient therapy for patients with hand eczema. The guideline is based on two Cochrane reviews of therapeutic and preventive interventions for HE. The remaining chapters were mainly developed and consented based on non‐systematic literature research by the expert group. The expert group consisted of members of allergological and occupational dermatological professional associations and working groups, a patient representative, and methodologists. The proposals for recommendations and key statements were consented by using a nominal group process during a consensus conference on September 15, 2022. The structured consensus‐building process was professionally moderated. This guideline is valid until February 22, 2028.

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Empfehlungen der Arbeitsgruppe „Photopatchtest“ der Deutschen Kontaktallergie‐Gruppe (DKG) zur Durchführung des Photopatchtests

Cited by 9 publications

References 0 publications

German S1 guideline: Contact dermatitis

German S1 guideline: Contact dermatitis

Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid

S2k guideline diagnosis, prevention, and therapy of hand eczema

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