Empagliflozin-induced severe osmotic nephrosis and acute renal injury in
advanced chronic kidney disease

Sia, Charmaine Si Min; Leong, Lester Chee Hao; Wong, Eddy W.Y.; Goh, Giap Hean; Leo, Christopher Cheang Han

doi:10.47102/annals-acadmedsg.2020526

Cited by 4 publications

(6 citation statements)

References 10 publications

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“…The SWE cannot accurately and quantitatively assess renal fibrosis, which will lead to an increase in P-SEN and a decrease in P-SPE. The results are consistent with the study of Sia et al [ 33 ]. A large number of published research results [ 34 - 36 ] show that kidney stiffness of the estimated value seems to increase with increasing in the CKD stage.…”

Section: Discussionsupporting

confidence: 94%

Shear Wave Elastography in the Evaluation of Renal Parenchymal Stiffness in Patients With Chronic Kidney Disease: A Meta-Analysis

Meng

et al. 2022

J Clin Med Res

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Background: Chronic kidney disease (CKD) is a progressive loss of renal function, mainly due to hypertension, diabetes, and primary kidney disease. The histopathological findings are that of glomerulosclerosis, tubulointerstitial fibrosis and loss of renal parenchyma characterized. Therefrom, CKD can lead to higher morbidity and mortality. Patients with CKD have multiple risk factors, and the prevention work is complicated and arduous. Therefore, it is important to quantify the severity of CKD. The aim of this study is to investigate the value of shear wave elastography (SWE) in the evaluating renal parenchymal stiffness in patients with CKD. Methods:We carried out the systematic search of databases for publications in PubMed, Embase and Cochrane Library on SWE evaluating renal fibrosis in patients with CKD. The Endnote X9, STATA 16, Review Manager 5.3 and other software were used to sort out documents, extract, integrate and analyze data. Results:The outcomes were utilized to appraise the diagnostic accuracy of SWE and diagnose the CKD with renal fibrosis. A total of 405 patients were enrolled and their data analysis results were as follows: summary of sensitivity (S-SEN) 84% (95% confidence interval (CI): 80-87%); specificity (S-SPE) 80% (95% CI: 76-84%); summary of DLR (digital light radiography) positive (DLR-P) 4.29 (95% CI: 3.43 -5.37); and DLR negative (DLR-N) 0.20 (95% CI: 0.16 -0.25). The corresponding areas under the curves of diagnostic odds ratio (DOR) and summary receiver operating characteristic curve (SROC) were 21.50 (95% CI: 14.69 -31.46) and 89% (95% CI: 86-92%), respectively.Conclusions: SWE is highly accurate and has clinical significance for evaluating renal fibrosis, especially when the shear modulus value is used as the threshold.

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Section: Discussionsupporting

confidence: 94%

Shear Wave Elastography in the Evaluation of Renal Parenchymal Stiffness in Patients With Chronic Kidney Disease: A Meta-Analysis

Meng

et al. 2022

J Clin Med Res

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“…e detection of these three inflammatory factors can then effectively reflect the degree of inflammatory damage in the body [20]. e results of the present study showed that patients receiving Huangkui capsules showed significantly lower levels of TNF-α, IL-6, and MCP-1, suggesting the effectiveness of Huangkui capsules plus methylprednisolone in improving the inflammatory response in patients with nephropathy [21].…”

Section: Discussionmentioning

confidence: 56%

“…The detection of these three inflammatory factors can then effectively reflect the degree of inflammatory damage in the body [ 20 ]. The results of the present study showed that patients receiving Huangkui capsules showed significantly lower levels of TNF- α , IL-6, and MCP-1, suggesting the effectiveness of Huangkui capsules plus methylprednisolone in improving the inflammatory response in patients with nephropathy [ 21 ]. The reason may be that the flavonoids such as myricetin, hyperin, and quercetin in Abelmoschus Manihot exhibit antibacterial and anti-inflammatory functions, improve immunity, and plus clear immune complexes in the circulatory system.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Huangkui Capsule plus Methylprednisolone in the Treatment of Nephropathy and the Effect on Urinary Protein and Serum Inflammatory Factors in Patients

Wan¹,

Zhou²,

Liu³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The study aimed to assess the clinical efficacy of Huangkui capsule plus methylprednisolone in the treatment of nephropathy and the effect on urinary protein and serum inflammatory factors in patients. Methods. Between June 2017 and July 2020, 90 patients with nephropathy admitted to our hospital were recruited after assessment of eligibility and assigned via the random number table method (1 : 1) to receive either methylprednisolone tablets (observation group) or methylprednisolone tablets plus Huangkui capsules (experimental group). All eligible patients were also given dipyridamole and valsartan. Outcome measures included clinical efficacy, urine protein, hematuria, serum inflammatory factor levels, and adverse reactions. Results. A higher clinical efficacy was observed in the experimental group versus the observation group ( P < 0.05 ). Huangkui capsules resulted in significantly lower levels of urine protein and hematuria in the experimental group versus the observation group after treatment ( P < 0.05 ). The serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and monocyte chemoattractant protein-1 (MCP-1) levels in the experimental group were significantly lower than those in the observation group after treatment ( P < 0.05 ). Huangkui capsules plus methylprednisolone were associated with a lower incidence of adverse events versus methylprednisolone ( P < 0.05 ). Conclusion. The clinical efficacy of Huangkui capsule plus methylprednisolone in the treatment of patients with nephropathy is remarkable. It can effectively mitigate the inflammatory responses and enhance renal function, with reliable clinical safety, so it is worthy of clinical application.

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“…This lesion has also been described in rats exposed to intravenous glucose where significant amounts of glucose are noted in the urine (4). The recent description of five cases of biopsy-proven osmotic nephropathy with SGLT2 inhibitors fits this experimental observation and will be discussed along with other medications (5)(6)(7).…”

mentioning

confidence: 73%

Drug-Induced Osmotic Nephropathy: Add SGLT2-Inhibitors to the List?

Perazella

Juncos

2022

Kidney360

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Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease

Cited by 4 publications

References 10 publications

Shear Wave Elastography in the Evaluation of Renal Parenchymal Stiffness in Patients With Chronic Kidney Disease: A Meta-Analysis

Shear Wave Elastography in the Evaluation of Renal Parenchymal Stiffness in Patients With Chronic Kidney Disease: A Meta-Analysis

Clinical Efficacy of Huangkui Capsule plus Methylprednisolone in the Treatment of Nephropathy and the Effect on Urinary Protein and Serum Inflammatory Factors in Patients

Drug-Induced Osmotic Nephropathy: Add SGLT2-Inhibitors to the List?

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