Emotional Working Memory in Alzheimer’s Disease Patients

Satler, Corina; Tomaz, Carlos

doi:10.1159/000329155

Cited by 18 publications

(17 citation statements)

References 83 publications

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“…It is worth pointing out that other studies have also found no evidence that older adults are better in remembering positive stimuli (e.g. [60], [61]). …”

Section: Discussionmentioning

confidence: 76%

Age-Related Differences in Cortical Activity during a Visuo-Spatial Working Memory Task with Facial Stimuli

et al. 2013

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Emotion, importantly displayed by facial expressions, is one of the most significant memory modulators. The interaction between memory and the different emotional valences change across lifespan, while young adults (YA) are expected to better recall negative events (Negativity Bias Hypothesis), older adults (OA) tend to focus on positive stimuli (Positivity Effect Hypothesis). This research work aims at verifying whether cortical electrical activity of these two age groups would also be differently influenced by emotional valences in a visuo-spatial working memory task. 27 YA (13 males) and 25 OA (14 males), all healthy volunteers, underwent electroencephalographic recordings (21 scalp electrodes montage), while performing the Spatial Delayed Recognition Span Task using a touch screen with different stimuli categories: neutral, positive and negative faces and geometric pictures. YA obtained higher scores than OA, and showed higher activation of theta and alpha bands in the frontal and midline regions, besides a more evident right-hemispheric asymmetry on alpha band when compared to OA. For both age groups, performance in the task was worse for positive faces than to negative and to neutral faces. Facial stimuli induced a better performance and higher alpha activation on the pre-frontal region for YA, and on the midline, occipital and left temporal regions for OA when compared to geometric figures. The superior performance of YA was expected due to the natural cognitive deficits connected to ageing, as was a better performance with facial stimuli due to the evolutionary importance of faces. These results were related to cortical activity on areas of importance for action-planning, decision making and sustained attention. Taken together, they are in accordance with the Negativity Bias but do not support the Positivity Effect. The methodology used was able to identify age-related differences in cortical activity during emotional mnemonic processing and may be interesting to future investigations.

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“…It is worth pointing out that other studies have also found no evidence that older adults are better in remembering positive stimuli (e.g. [60], [61]). …”

Section: Discussionmentioning

confidence: 76%

Age-Related Differences in Cortical Activity during a Visuo-Spatial Working Memory Task with Facial Stimuli

et al. 2013

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“…In fact, declines in general WM performance in DAT patients are well documented [12], while their ability to maintain and manipulate emotional information in WM is less certain [8][9][10][11]. The present study examined DAT patients' performance in a WM task, the operation span test, in which affective words were also presented.…”

Section: Discussionmentioning

confidence: 96%

“…In fact, a series of previous studies with DAT patients has yielded mixed results. For example, Kensinger and colleagues [8] in a sentence generation task and with verbal descriptions [9] found no emotional enhancement effect, while Fleming et al, [10] in an immediate recall task for emotional words and Satler and Tomaz [11] who tested DAT patients' ability to recognize emotional information in a visuo-spatial WM task found emotional benefits. Consequently, generalizing WM emotional enhancement effects in DAT must be taken with caution and it may be that results depend on the type of WM task used.…”

Section: Introductionmentioning

confidence: 98%

Is working memory affective in dementia of alzheimer's type?

Mammarella¹,

Fairfield²,

Domenico³

et al. 2013

Neurosci Discov

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Background: The aim of the present study was to examine whether patients with Dementia of Alzheimer's Type (DAT) show a working memory emotional enhancement effect. Methods: We used an affective version of the working memory operation span test that included negative and positive words as well as neutral ones (as in the classical version). Results: Results showed that while healthy older adults performed better with emotional compared to neutral words, emotional effects were nullified in DAT patients. Conclusions: Altogether, results indicate that DAT patients do not benefit from emotional cues when maintenance and manipulation of information in working memory are required.

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“…In 2010, approximately 4.7 million individuals of 65 years old and more seasoned were living with Alzheimer's sickness in the US. Alzheimer's ailment association gives factual report an extent of the populace influenced a little more than a tenth of individuals in the more than 65 age bunch have the infection in the US in 2013 [10][11][12]. AD is the main source of dementia around the world, influencing more than half of the general number of deranged people, which has been assessed to associate with 24 million over all countries.…”

Section: Introductionmentioning

confidence: 99%

A Review on “New Treatment Strategies for Alzheimer’s Disease as Neurodegenerative Disease and Its Risk Factor Cause, Symptoms, and Treatment at Worldwide”

Bhor¹

2016

Asian J Pharm Clin Res

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Alzheimer's disease (AD) is a dynamic and irreversible neurodegenerative illness and relates to the most widely recognized reason for dementia around the world. AD is a dynamic and lethal cerebrum ailment. Alzheimer's obliterates mind cells, bringing on memory issue or misfortune and issues with speculation and conduct sufficiently serious to influence work, long lasting leisure activities or social life. Alzheimer's illness is quickly becoming worldwide, but there is no cure for it. Now, accessible medications just give symptomatic help and do not mediate in infection prepare adequately enough to avert or cure it. Various late studies have reported that working memory does not appear to demonstrate regular age-related deficiencies in solid more established grown-ups when enthusiastic data are included. Indeed, contingent upon the capacity included, patients might demonstrate an enthusiastic advantage in their working memory execution. Moreover, this advantage is not generally obviously one-sided (e.g., toward negative or positive data). We decipher this intricate example of results as an outcome of the cooperation between numerous components including the seriousness of AD, the nature of emotional jolts, and sort of working memory errand. Clinical advantages of the accessible pharmacological treatment for AD with antidementia drugs (to be specific cholinesterase inhibitors and Memantine) are obvious. In an unexpected way, learns about the transient capacity to encode and effectively control enthusiastic data in dementia of Alzheimer's sort are few and have yielded blended results.

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Emotional Working Memory in Alzheimer’s Disease Patients

Cited by 18 publications

References 83 publications

Age-Related Differences in Cortical Activity during a Visuo-Spatial Working Memory Task with Facial Stimuli

Age-Related Differences in Cortical Activity during a Visuo-Spatial Working Memory Task with Facial Stimuli

Is working memory affective in dementia of alzheimer's type?

A Review on “New Treatment Strategies for Alzheimer’s Disease as Neurodegenerative Disease and Its Risk Factor Cause, Symptoms, and Treatment at Worldwide”

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