Emotional symptoms, quality of life and cytokine profile in hemodialysis patients

Montinaro, Vincenzo; Iaffaldano, Gp; Granata, Simona; Porcelli, Piero; Todarello, Orlando; Fp, Schena; Pertosa, Giovanni

doi:10.5414/cnp73036

Cited by 70 publications

(77 citation statements)

References 13 publications

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“…Emotional changes, anxiety and depression have also been reported in cases of chronic renal failure (Montinaro et al 2010). Our study is consistent with these findings and hence our model can be used as an excellent tool to understand the pathophysiology and progression of such changes seen in chronic renal failure.…”

Section: Locomotor Exploratory and Emotional Activitymentioning

confidence: 99%

Psychomotor functions at various weeks of chronic renal failure in rats

Chandanathil¹,

Upadhya

Bhat³

2014

Cogn Neurodyn

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In chronic renal failure there is a gradual retention of substances in the tissues and body fluids, called as uremic retention toxins, which can bring about a number of biochemical activities in the body. Chronic renal insufficiency also leads to progressive behavioural conflict. Uremic toxins can affect both the central and the peripheral nervous system. Uremic encephalopathy is also associated with problems in cognition and memory. To study the psychomotor functional disorders in rats with progressive chronic renal failure surgical nephrectomy was done by resection method. The animals were grouped into two control groups, Sham control (SC) and normal control (NC) and two uremic groups, moderate uremia (G M ) and severe uremia (G S ). Psychomotor analysis was done by passive avoidance and open field in these animals at 4, 8, 12, and 16 weeks. After the incubation period, the nephrectomised groups (G M and G S ) showed significant changes in exploratory, locomotor and emotional behaviour when compared to the controls (NC and SC). Psychomotor changes involve poor cognition, reduced memory, reduced locomotor activity and decreased exploratory drive and emotional disturbance like increased fear during the initial stages. During the later stages a restless behaviour was noticed, associated with diminished fear.

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Section: Locomotor Exploratory and Emotional Activitymentioning

confidence: 99%

Psychomotor functions at various weeks of chronic renal failure in rats

Chandanathil¹,

Upadhya

Bhat³

2014

Cogn Neurodyn

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“…Malnutrition in dialysis patients might also be related to poor intake, or the result of chronic inflammation (Stenvinkel et al, 1999). Cytokines productions, particularly IL-6, might induce protein catabolism and lipolysis (Memoli et al, 2002), and cytokines have a strong negative correlation with serum albumin levels in HD patients (Montinaro et al, 2010). Thus, chronic inflammation and malnutrition might result in fatigue by either directly activating the central nervous system through adrenal axis or by indirectly triggering multisystem deregulation (Jhamb et al, 2008).…”

Section: Fatiguementioning

confidence: 99%

“…Biological factors that have been associated with QoL include altered hemoglobin, albumin, ferritin, CRP, IL-6, IL-8, and TNF-α levels (Farag et al, 2011;Kalender et al, 2007a;Montinaro et al, 2010;Perlman et al, 2005). Poor exercise tolerance and muscle weakness may limit daily activity, again causing poor QoL (Hsieh et al, 2007;Sakkas et al, 2003).…”

Section: Decreased Quality Of Life (Qol)mentioning

confidence: 99%

The Psychological Impact of Hemodialysis on Patients with Chronic Renal Failure

Wang¹,

Chen²

2012

Renal Failure - The Facts

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“…More precisely, a relation between the levels of C-reactive protein (CRP) and interleukin-6 (IL-6) with reduced cognitive performance in healthy subjects and in older adults, has been suggested [19]. In addition, in HD patients it has also been found that abnormal production of cytokines is associated with cognitive impairment [20]. Severe or prolonged systemic inflammation can induce harmful changes in cognitive function such as synaptic loss, dendritic alterations, neuronal apoptosis, suppression of BDNF, impaired neurogenesis, memory dysfunction, and altered hypothalamic function by activating microglia [21].…”

Section: Introductionmentioning

confidence: 99%