Emotional stress and sympathetic activity: Contribution of dorsomedial hypothalamus to cardiac arrhythmias

Fontes, Marco Antônio Peliky; Xavier, Carlos Henrique; Marins, Fernanda Ribeiro; Limborço-Filho, Marcelo; Vaz, Gisele Cristiane; Müller-Ribeiro, Flávia Camargos de Figueirêdo; Nalivaiko, Eugene

doi:10.1016/j.brainres.2014.01.043

Cited by 51 publications

(31 citation statements)

References 89 publications

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“…(Strike et al, 2006;Vlastelica, 2008). However, it appears that activation of the sympathetic nervous system plays a critical role in view of the fact that the majority of cardiac deaths occur during times of augmented sympathetic activity (Fontes et al, 2014;Muller, Tofler, & Verrier, 1995). In the present study, we induced sympathetic stimulation via the CPT as it alters aortic hemodynamics and coronary blood flow offering a window to evaluate cardiovascular functioning (Casey et al, 2008;Momen et al, 2009).…”

Section: Discussionmentioning

confidence: 91%

Impact of negative affectivity and trait forgiveness on aortic blood pressure and coronary circulation

et al. 2014

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Prior research suggests that negative affectivity (NA) may have a direct adverse effect on coronary circulation, whereas forgiveness may provide cardioprotection. This study examined whether NA and forgiveness were independently related to aortic hemodynamics and the subendocardial viability index (SVI), a marker of coronary perfusion. A sample of 131 adults (M = 21.11 years, SD = 2.52) were evaluated for NA (depression, anxiety, and anger symptoms) and forgiveness (Tendency to Forgive Scale; TTF). Aortic hemodynamic parameters via applanation tonometry were assessed at rest and during sympathostimulation (cold pressor test; CPT). Hierarchical multiple regression analyses of resting values showed that NA was related to higher aortic blood pressure (ABP) and lower SVI. After controlling for demographics and for NA, TTF scores were significantly associated with decreased ABP, but increased SVI. CPT changes from baseline indicated that, after controlling for demographics and NA, TTF scores were significantly associated with SVI. Results indicate that NA significantly predicts ABP and decreased SVI. Conversely, forgiveness seems to provide cardioprotection by evoking decreased ABP while improving SVI.

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Section: Discussionmentioning

confidence: 91%

Impact of negative affectivity and trait forgiveness on aortic blood pressure and coronary circulation

et al. 2014

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“…Using bombesin as a "nonselective agonist" for BB receptors, we have been examining central regulation mechanisms of stress responses focusing on the sympathoadrenomedullary system, one of the components of the primary systems for maintaining or reinstating homeostasis during stress exposure (Bartolomucci et al, 2003;Ulrich-Lai and Herman, 2009;Fontes et al, 2014). We previously reported that intracerebroventricularly administered bombesin induced secretion of noradrenaline and adrenaline from the rat adrenal medulla through brain BB 2 receptors Yokotani et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

A Stress-Related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat

Shimizu

Higashi

et al. 2016

Journal of Pharmacology and Experimental Therapeutics

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Stress exacerbates symptoms of bladder dysfunction including overactive bladder and bladder pain syndrome, but the underlying mechanisms are unknown. Bombesin-like peptides and bombesin receptor types 1 and 2 (BB 1 and BB 2 , respectively) in the brain have been implicated in the mediation/integration of stress responses. In this study, we examined effects of centrally administered bombesin on micturition, focusing on their dependence on 1) the sympathoadrenomedullary system (a representative mechanism activated by stress exposure) and 2) brain BB receptors in urethane-anesthetized (1.0-1.2 g/kg, i.p.) male rats. Intracerebroventricularly administered bombesin significantly shortened intercontraction intervals (ICI) at both doses (0.1 and 1 nmol/animal) without affecting maximal voiding pressure. Bombesin at 1 nmol induced significant increments of plasma noradrenaline and adrenaline levels, which were both abolished by acute bilateral adrenalectomy. On the other hand, These results suggest that brain bombesin and BB receptors are involved in facilitation of the rat micturition reflex to induce bladder overactivity, which is independent of the sympathoadrenomedullary outflow modulation.

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“…Most important feedback mechanism in cardiovascular system is baroreflex of short-term arterial pressure regulation. Though central control mechanisms of the sympathetic tone are more complex and are associated with behavioral strategies, (such as those involved in exercise or in response to emotional stress), emotional stress can exert influence on the sympathetic activity both in short and long term [58].…”

Section: Personality Traitsmentioning

confidence: 99%

Stress as a Risk Factor for Cardiovascular Events

C¹

2015

Cardiol Pharmacol

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Emotional stress and sympathetic activity: Contribution of dorsomedial hypothalamus to cardiac arrhythmias

Cited by 51 publications

References 89 publications

Impact of negative affectivity and trait forgiveness on aortic blood pressure and coronary circulation

Impact of negative affectivity and trait forgiveness on aortic blood pressure and coronary circulation

A Stress-Related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat

Stress as a Risk Factor for Cardiovascular Events

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