Emotional reactivity in mice may not be inherited but influenced by parents

Calatayud, François; Coubard, Stéphanie; Belzung, Catherine

doi:10.1016/j.physbeh.2003.10.001

Cited by 69 publications

(49 citation statements)

References 46 publications

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“…Using backcrosses of hybrids from BALB/c and C57BL/6, i.e. using genetically identical pups which were exposed to different mothering styles, Calatayud et al (2004) were able to verify their previous finding that maternal care can affect emotional reactivity as measured in the elevated plus maze and a free exploration paradigm. From rat studies, it is known that variations in maternal licking particularly affect the development of stable individual differences in emotionality.…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 66%

“…Therefore, it can be assumed that environmental factors contribute to such differences as well. Indeed, such factors have proven to hold strong influence on the development of emotionality (Calatayud and Belzung 2001;Calatayud et al 2004;Francis et al 2003; for review see: Gordon and Hen 2004) and out of these, maternal care is a crucial one (Caldji et al 1998;Francis et al 1999;Menard et al 2004;Menard and Hakvoort 2007;Wöhr and Schwarting 2008;Zhang et al 2005).…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 99%

“…Apart from the embryo-transfer study by Francis et al (2003), this was indicated in postnatal cross-fostering studies (Priebe et al 2005;Zaharia et al 1996) and reciprocal breeding of inbred mouse strains (Calatayud and Belzung 2001;Calatayud et al 2004). Using backcrosses of hybrids from BALB/c and C57BL/6, i.e.…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 99%

“…Evidence for maternal effects on offspring development came from reciprocal breeding of inbred mouse strains (Calatayud and Belzung 2001;Calatayud et al 2004) and cross-fostering studies (Francis et al 2003;Priebe et al 2005;Zaharia et al 1996; for review see: Gordon and Hen 2004). By using an embryo-transfer, Francis et al (2003) were able to show that early environmental factors hold strong influence on anxiety-related behavior in adult mice.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

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Infant rodents emit ultrasonic vocalizations when isolated from dam and littermates. Due to the context of their occurrence and the well described bidirectional modulation by substances known for their capability to influence emotionality, it was postulated that such calls reflect a negative affective state akin anxiety. Comparative studies observed pronounced differences in calling behavior between strains, which were paralleled by differences in maternal care. Therefore, it was recently hypothesized that early environmental factors may have strong impact on call production. Here, the relative contributions of genetic background, gender, and early environmental factors on calling behavior in C57BL/6JOlaHsd and C57BL/6NCrl were studied by using an embryo-transfer procedure. The results show that these sub-strains differ in the amount of calling and specific call features, like call frequency and amplitude. The embryo-transfer procedure indicated that the observed differences in the amount of ultrasonic calling are dependent on the dyadic interaction between mother and pup. Conversely, call features were primarily dependent on the genotype of the pup. Thus, call frequency and frequency modulation were solely dependent on the pup, i.e. its genotype and gender. However, there was one exception, namely call amplitude, which was solely dependent on the genotype of the mother, i.e. on early environmental factors. Furthermore, it was shown that particularly changes in call amplitude might be of high functional relevance, since a sub-strain dependent preference towards pups emitting calls with high amplitudes was observed. In total, it can be concluded that both genomic and nongenomic factors can tune calling behavior in mouse pups.

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Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 66%

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 99%

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

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“…Social transmission of emotional traits across generations has been reported in mice and rats, especially through maternal care [11,18]. It is possible that the apparent absence of maternal effects in our study was related to the high degree of novelty imposed on the lambs under our testing conditions.…”

Section: Adjusted Means and P Values In Italicsmentioning

confidence: 72%

Genetic analysis of emotional reactivity in sheep: effects of the genotypes of the lambs and of their dams

et al. 2005

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-A total of 1347 weaned lambs from eight genotypes were tested over five consecutive years: Romanov (ROM) and Lacaune (LAC) pure breeds, the two F1 crossbreeds (RL and LR) and the offspring of ewes from these four genotypes sired with Berrichon-du-Cher rams (BCF). The lambs were individually exposed to three challenging tests involving novelty, human contact and social isolation. Ten synthetic variables were used to express social reactivity (i.e., active vs. passive strategy), exploratory activity and reactivity to humans. BCF crossbreds were more active (i.e., high bleats, locomotion and attempts to escape) than purebreds and F1. In contrast, ROM expressed more passive responses (i.e., low bleats and vigilance postures) than LAC and BCF crossbreds. In addition, ROM approached a motionless human less and had longer flight distances to an approaching human than did LAC and BCF crossbreds. When restrained, ROM, and to a lesser extent B×ROM and B×LR, avoided human contact more than did LAC, RL and B×LAC. Most of these differences were explained by direct additive genetic effects while maternal influences or heterosis effects were rarely significant. The highest heritability was for high bleats (h 2 = 0.48). Females were more active and avoided human contact more than did males.genetics / emotional reactivity / human contact / social isolation / sheep

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