Emotional reactivity in mice, a case of nongenetic heredity?

Calatayud, François; Belzung, Catherine

doi:10.1016/s0031-9384(01)00566-2

Cited by 57 publications

(33 citation statements)

References 55 publications

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“…A third study reported that naturalistically occurring poor maternal care led to an increased anhedonic response to CMS in outbred Wistar rats; the response to antidepressant treatment was not examined (Henningsen et al 2012). However, there is evidence that greater adult emotionality between mouse strains may to some extent reflect differences in early maternal care (Calatayud and Belzung 2001), and this is not associated with resistance to antidepressant treatments ). Overall, these data do not give confidence that work with combined early-life and late stress models will significantly improve the research environment for the development of treatments for antidepressant-resistant depression.…”

Section: Early Life Stressmentioning

confidence: 99%

Treatment-resistant depression: are animal models of depression fit for purpose?

2015

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Section: Early Life Stressmentioning

confidence: 99%

Treatment-resistant depression: are animal models of depression fit for purpose?

2015

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“…This is not only true for proximal factors of causation but also for distal factors that can contribute to increase subject's sensibility toward threats. For example, impoverishment of the breeding conditions, deficient maternal care during perinatal period or early maternal separation, may induce an increase in anxiety in the individuals when adult, both in animals and in humans ( [15,17,86]). However, this criterion seems rather difficult to fulfill for pathological anxiety as in most cases (except for post-traumatic stress disorder, a disorder defined by its etiology), the psychological factors underlying the disorder have not been described.…”

Section: Construct 6aliditymentioning

confidence: 99%

Measuring normal and pathological anxiety-like behaviour in mice: a review

Belzung

Griebel

2001

Behavioural Brain Research

778

500

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Measuring anxiety-like behaviour in mice has been mostly undertaken using a few classical animal models of anxiety such as the elevated plus-maze, the light/dark choice or the open-field tests. All these procedures are based upon the exposure of subjects to unfamiliar aversive places. Anxiety can also be elicited by a range of threats such as predator exposure. Furthermore, the concepts of 'state' and 'trait' anxiety have been proposed to differentiate anxiety that the subject experiences at a particular moment of time and that is increased by the presence of an anxiogenic stimulus, and anxiety that does not vary from moment to moment and is considered to be an 'enduring feature of an individual'. Thus, when assessing the behaviour of mice, it is necessary to increase the range of behavioural paradigms used, including animal models of 'state' and 'trait' anxiety. In the last few years, many mice with targeted mutations have been generated. Among them some have been proposed as animal models of pathological anxiety, since they display high level of anxiety-related behaviours in classical tests. However, it is important to emphasise that such mice are animal models of a single gene dysfunction, rather than models of anxiety, per se. Inbred strains of mice, such as the BALB/c line, which exhibits spontaneously elevated anxiety appear to be a more suitable model of pathological anxiety.

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“…Therefore, it can be assumed that environmental factors contribute to such differences as well. Indeed, such factors have proven to hold strong influence on the development of emotionality (Calatayud and Belzung 2001;Calatayud et al 2004;Francis et al 2003; for review see: Gordon and Hen 2004) and out of these, maternal care is a crucial one (Caldji et al 1998;Francis et al 1999;Menard et al 2004;Menard and Hakvoort 2007;Wöhr and Schwarting 2008;Zhang et al 2005).…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 99%

“…Apart from the embryo-transfer study by Francis et al (2003), this was indicated in postnatal cross-fostering studies (Priebe et al 2005;Zaharia et al 1996) and reciprocal breeding of inbred mouse strains (Calatayud and Belzung 2001;Calatayud et al 2004). Using backcrosses of hybrids from BALB/c and C57BL/6, i.e.…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 99%

“…Evidence for maternal effects on offspring development came from reciprocal breeding of inbred mouse strains (Calatayud and Belzung 2001;Calatayud et al 2004) and cross-fostering studies (Francis et al 2003;Priebe et al 2005;Zaharia et al 1996; for review see: Gordon and Hen 2004). By using an embryo-transfer, Francis et al (2003) were able to show that early environmental factors hold strong influence on anxiety-related behavior in adult mice.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

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Infant rodents emit ultrasonic vocalizations when isolated from dam and littermates. Due to the context of their occurrence and the well described bidirectional modulation by substances known for their capability to influence emotionality, it was postulated that such calls reflect a negative affective state akin anxiety. Comparative studies observed pronounced differences in calling behavior between strains, which were paralleled by differences in maternal care. Therefore, it was recently hypothesized that early environmental factors may have strong impact on call production. Here, the relative contributions of genetic background, gender, and early environmental factors on calling behavior in C57BL/6JOlaHsd and C57BL/6NCrl were studied by using an embryo-transfer procedure. The results show that these sub-strains differ in the amount of calling and specific call features, like call frequency and amplitude. The embryo-transfer procedure indicated that the observed differences in the amount of ultrasonic calling are dependent on the dyadic interaction between mother and pup. Conversely, call features were primarily dependent on the genotype of the pup. Thus, call frequency and frequency modulation were solely dependent on the pup, i.e. its genotype and gender. However, there was one exception, namely call amplitude, which was solely dependent on the genotype of the mother, i.e. on early environmental factors. Furthermore, it was shown that particularly changes in call amplitude might be of high functional relevance, since a sub-strain dependent preference towards pups emitting calls with high amplitudes was observed. In total, it can be concluded that both genomic and nongenomic factors can tune calling behavior in mouse pups.

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Emotional reactivity in mice, a case of nongenetic heredity?

Cited by 57 publications

References 55 publications

Treatment-resistant depression: are animal models of depression fit for purpose?

Treatment-resistant depression: are animal models of depression fit for purpose?

Measuring normal and pathological anxiety-like behaviour in mice: a review

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

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