Emotional Reactivity and Regulation Following Citalopram Therapy in Children and Adolescents with Anxiety Disorders

Carthy, Tal; Benaroya-Milshtein, Noa; Valevski, Avi; Apter, Alan

doi:10.1089/cap.2015.0067

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…In accordance with studies conducted across numerous animal taxa, the administration of the selective serotonin reuptake inhibitor citalopram monotonically decreased the observed anxiety-related response [9,41,42]. The possibility of modulating anxiety-related behavior through serotonergic agonists is widely documented in zebrafish [57][58][59][60].…”

Section: Discussionsupporting

confidence: 62%

“…Ethanol and citalopram have been selected based on their known efficacy in modulating fear-and anxiety-related behaviors across a number of taxa ranging from humans [40,41] to rodents [42,43] and fish [9,23,44]. In zebrafish, we have already demonstrated that ethanol administration modulates individual behavior in response to the same predatorial stimulus adopted in this study [26].…”

Section: Introductionmentioning

confidence: 99%

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Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish

Clément

Macrı̀

Porfiri

2020

Behavioural Brain Research

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Zebrafish are becoming a species of choice in psychopharmacology, laying a promising path to refined pharmacological manipulations and high-throughput behavioral phenotyping. The field of robotics has the potential to accelerate progress along this path, by offering unprecedented means for the design and development of accurate and reliable experimental stimuli. In this work, we demonstrate, for the first time, the integration of robotic predators in place conditioning experiments. We hypothesized zebrafish to be capable of forming a spatial association under a simulated predation risk. We repeatedly exposed experimental subjects to a robotic heron impacting the water surface and then evaluated their spatial avoidance within the experimental tank in a subsequent predator-free test session. To pharmacologically validate the paradigm, we tested zebrafish in drug-free conditions (control groups) or in response to three different concentrations of citalopram (30, 50, and 100 mg/L) and ethanol (0.25, 0.50, and 1.00%). Experimental data indicate that, when tested in the absence of the conditioning stimulus, zebrafish displayed a marked preference for the bottom of the test tank, that is, the farthest location from the simulated attacks by the robotic heron. This conditioned geotaxis was reduced by the *

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish

Clément

Macrı̀

Porfiri

2020

Behavioural Brain Research

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“…ED leads to psychopathology and a number of externalizing and internalizing symptoms, including anxiety, mood dysregulation, impulsiveness, behavioral issues, and serious debilitating social problems. Two forms of stress related sequelae have to be considered: (i) acute emotional cues triggering experiential, behavioral, central and peripheral physiological systems ( 458 ), and (ii) chronic mental stress resulting from continuous burdens, such as maltreatment or familial discord, leading to personality modification, ED, and related problems.…”

Section: Resultsmentioning

confidence: 99%

“…Antidepressants and mood stabilizing medication - alleviating anxiety, improving mood, and decreasing maniac symptoms ( 458 , 461 )…”

Section: Resultsmentioning

confidence: 99%

Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review

et al. 2021

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Background: Emotional dysregulation (ED) is a transdiagnostic construct defined as the inability to regulate the intensity and quality of emotions (such as, fear, anger, sadness), in order to generate an appropriate emotional response, to handle excitability, mood instability, and emotional overreactivity, and to come down to an emotional baseline. Because ED has not been defined as a clinical entity, and because ED plays a major role in child and adolescent psychopathology, we decided to summarize current knowledge on this topic based on a narrative review of the current literature.Methods: This narrative review is based on a literature search of peer-reviewed journals. We searched the databases ERIC, PsycARTICLES, PsycINFO and PSYNDEX on June 2, 2020 for peer reviewed articles published between 2000 and 2020 in English language for the preschool, school, and adolescent age (2–17 years) using the following search terms: “emotional dysregulation” OR “affect dysregulation,” retrieving 943 articles.Results: The results of the literature search are presented in the following sections: the relationship between ED and psychiatric disorders (ADHD, Mood Disorders, Psychological Trauma, Posttraumatic Stress Disorder, Non-suicidal Self-Injury, Eating Disorders, Oppositional Defiant Disorder, Conduct Disorder, Disruptive Disruptive Mood Dysregulation Disorder, Personality Disorders, Substance Use Disorder, Developmental Disorders, Autism Spectrum Disorder, Psychosis and Schizophrenia, and Gaming Disorder), prevention, and treatment of ED.Conclusion: Basic conditions of ED are genetic disposition, the experience of trauma, especially sexual or physical abuse, emotional neglect in childhood or adolescence, and personal stress. ED is a complex construct and a comprehensive concept, aggravating a number of various mental disorders. Differential treatment is mandatory for individual and social functioning.

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“…Studies have reported a range of effects with SSRI treatment either alone or in combination with CBT which are associated with clinical response, although most studies use self-report measures making it difficult to understand the underlying mechanisms of change. These include improved emotional reappraisal, 92 enhanced problem solving ability, 93 decreased perfectionism, 94 decreased hopelessness, 95 improved coping efficacy, 96 decreased negative interpretative bias, 97 reduced somatic symptoms, 98 reduced social distress and behavioural avoidance 99 and improved sleep. 100,101…”

Section: Corticolimbic Circuitry and Affective Processingmentioning

confidence: 99%

The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action

Murphy

Capitão

Giles

et al. 2021

The Lancet Psychiatry

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Emotional Reactivity and Regulation Following Citalopram Therapy in Children and Adolescents with Anxiety Disorders

Cited by 8 publications

References 57 publications

Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish

Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish

Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review

The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action

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