Emotional processing and disgust sensitivity in OCD patients with and without contamination-type obsessive-compulsive symptoms – An fMRI study.

Rickelt, Judith; Wit, Stella J. de; Werf, Ysbrand D. van der; Schruers, Koen; Vries, Froukje E. de; Heuvel, Odile A. van den

doi:10.1016/j.jocrd.2019.100443

Cited by 5 publications

(3 citation statements)

References 67 publications

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“…Entering the temporal pole seed ( x,y,z = −44, 24, −18) and a 5 mm diameter into Neurosyth, a website-based, automated meta-analysis of fMRI studies (Yarkoni et al., 2011), a number of studies have found this area to be involved in emotion, particularly disgust (e.g., Shapira et al., 2003; Schienle et al., 2005). This fits well with the OCD literature suggesting exaggerated and inappropriate disgust reactions may drive some symptoms (Bhikram et al., 2017), particularly with respect to Contamination symptoms (Rickelt et al., 2019).…”

Section: Discussionsupporting

confidence: 89%

Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

Jaspers‐Fayer

Lin

Chan

et al. 2019

NeuroImage: Clinical

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Section: Discussionsupporting

confidence: 89%

Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

Jaspers‐Fayer

Lin

Chan

et al. 2019

NeuroImage: Clinical

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“…Again, neuroimaging evidence supports the role of the dysregulation of insula activity in OCD symptomatology, this time focusing on disgust sensitivity (Viol et al, 2019). On the other hand, Viol et al (2019) stated that disgust sensitivity is related to the activation of DLPFC, caudate nucleus and visual association cortex (VAC) (Rickelt et al, 2019). More studies are required to resolve or explain the inconsistency.…”

Section: Feeling Of Disgustmentioning

confidence: 98%

Moral judgments in obsessive-compulsive disorder: a narrative mini-review

2020

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Obsessive-compulsive disorder (OCD) is a prevalent mental disorder characterized by intrusive thoughts (obsessions) and ensuing rituals (compulsions). Although OC patients exhibit various cognitive and behavioral problems, rigid and hypersensitive moral judgments are known to be one of the most striking problems in these patients. There is evidence indicating that OC patients often tend to make deontological judgments in moral dilemmas, significantly more than the healthy population. Therefore, numerous studies are dedicated to understanding the underlying cognitive processes responsible for such variation of moral judgments in OCD, which are reviewed and discussed in the current paper. First, it is previously discussed that abnormal moral judgments in OCD are due to executive dysfunctions. These dysfunctions include impaired cognitive control resulting in the domination of strong, uncontrolled emotional responses, impaired cognitive flexibility resulting in the inability to switch between aspects of a scenario, and decreased capacity and overload of working memory and its inability to resist the interfering information. The dual-process theory also emphasizes and acknowledges the role of executive functions in moral judgments. Second, it is thought that disobeying moral norms results in the abnormal feeling of deontological guilt in OC patients, to which these patients are highly sensitive. Feeling of guilt is also thought to be correlated with OCD symptomatology. The third impairment contributing to abnormal moral judgments in OCD is known to be the abnormal feeling of disgust for moral violations and immoral unwanted intrusive thoughts, which is regarded as one of the major causes of OCD symptoms. Finally, the abnormal fear of responsibility and being criticized due to not acting morally is regarded as one of the primary impairments contributing to the abnormal moral judgments in OCD. In conclusion, this review sheds light on the most striking cognitive and affective impairments contributing to abnormal moral judgments in OCD.

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“…Hildebrandt et al, 2015) or neuroimaging methods (cf. Rickelt et al, 2019). Importantly, further research should continue to involve clinical samples so that firm conclusions could be made with regard to the contribution of specific findings to the knowledge on the psychopathology of AN.…”

Section: Future Directionsmentioning

confidence: 99%

Self‐disgust and disgust sensitivity are increased in anorexia nervosa inpatients, but only self‐disgust mediates between comorbid and core psychopathology

Kot

Grzegorzewski

Kostecka

et al. 2021

Euro Eating Disorders Rev

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Objective The possible role of abnormal disgust processing in the development and course of anorexia nervosa (AN) has been emphasized in theoretical models and research. However, disgust toward external stimuli and self‐disgust have not yet been investigated together in a clinical sample of AN patients. Therefore, the purpose of the study was to measure these constructs and examine their role in shaping eating pathology in AN patients and healthy controls (HCs), considering comorbid depressive and anxiety psychopathology. The study also aimed at testing the possible mediational roles of both disgust types in the associations between comorbid psychopathology and eating disorders (EDs) characteristics. Method Altogether, 63 inpatients with AN and 57 HCs partook in the study. Participants completed the Eating Disorder Inventory‐3, State‐Trait Anxiety Inventory, Beck Depression Inventory‐II, Disgust Scale–Revised and Self‐Disgust Scale. Results AN patients manifested higher self‐disgust and disgust sensitivity than HCs. In addition, self‐disgust predicted the severity of EDs characteristics and mediated the links of depressive symptoms and trait anxiety with EDs characteristics in both groups. Discussion Our findings imply the putative role of self‐disgust in the development of EDs psychopathology in HCs and in its maintenance in AN patients.

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Emotional processing and disgust sensitivity in OCD patients with and without contamination-type obsessive-compulsive symptoms – An fMRI study.

Cited by 5 publications

References 67 publications

Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

Moral judgments in obsessive-compulsive disorder: a narrative mini-review

Self‐disgust and disgust sensitivity are increased in anorexia nervosa inpatients, but only self‐disgust mediates between comorbid and core psychopathology

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