Emotional overactivity in patients with irritable bowel syndrome

Fournier, Alicia; Mondillon, Laurie; Dantzer, Cécile; Gauchez, Anne-Sophie; Ducros, Véronique; Mathieu, Nicolas; Faure, Patrice; Canini, Frédéric; Bonaz, Bruno; Pellissier, Sonia

doi:10.1111/nmo.13387

Cited by 21 publications

(18 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The overall study design consisted of two parts. The analyses presented here concern only the first part of the study [for a complete description of the study see Fournier and colleagues (29)].…”

Section: Methodsmentioning

confidence: 99%

“…The Ethical Committee of the CHU approved the study (ref: CPP 08-CHUG-23; ClinicalTrials.gov Identifier: NCT010950421). Some of the results of this protocol have already been published twice (14,29).…”

Section: Participants and Ethics Statementmentioning

confidence: 99%

“…Besides differences in stress mediator regulation, IBS and IBD also present an impairment in interoception (26,27) and high levels of alexithymia (28,29). Interoception refers to the ability to accurately detect internal body changes.…”

Section: Introductionmentioning

confidence: 99%

“…Alexithymia is a personality construct that implies difficulties identifying and describing one's own feelings, limited imaginative processes, an externally oriented cognitive style, and difficulties in distinguishing between feelings and bodily sensations (40)(41)(42). This construct is associated with many disorders, such as gastrointestinal pathologies (28,29). This association can be explained by deficits in the strategies used in emotion regulation (43).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome

et al. 2020

View full text Add to dashboard Cite

Alexithymia is usually described by three main dimensions difficulty identifying feelings (DIF), difficulty describing feelings (DDF), and externally oriented thinking (EOT). The most commonly used questionnaire investigating alexithymia, the Toronto Alexithymia Scale (TAS-20), supports this three-factor structure. One important assumption is that alexithymia severity is associated to vulnerability to somatic diseases, among them gastrointestinal disorders. However, the association between alexithymia and gastrointestinal disorders is not systematic, thus questioning the role of alexithymia as a vulnerability factor for those illnesses. A recent factor analysis suggested another fourfactor structure for the TAS-20: difficulties in awareness of feelings (DAF), difficulties in interoceptive abilities (DIA), externally oriented thinking (EOT), and poor affective sharing (PAS). We assume that DIA and DAF might be more relevant to investigate the association between alexithymia and gastrointestinal disorders. The rationale is that DIA and DAF reflect impairments in emotion regulation that could contribute to an inappropriate autonomic and HPA axis homeostasis in irritable bowel syndrome (IBS), ulcerative colitis (UC), or Crohn's disease (CD). The aim of this study was to investigate whether DIA and DAF are associated with the presence of IBS, UC or CD, while checking for anxiety, depression, parasympathetic (vagus nerve) activity and cortisol levels. We recruited control participants (n=26), and patients in remission who were diagnosed with IBS (n=24), UC (n=18), or CD (n=21). Participants completed questionnaires to assess anxiety, depression, and alexithymia. A blood sample and an electrocardiogram were used to measure the level of cortisol and parasympathetic activity, respectively. Logistic regressions with the four-factor structure of the TAS-20 revealed that DIA was a significant predictor of IBS (W(1)=6.27, p=.01). Conversely, DIA and DAF were not significant predictors in CD and UC patients. However, low cortisol level was a Frontiers in Psychiatry | www.frontiersin.org

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Participants and Ethics Statementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although the etiopathogenesis of IBS is multifactorial and not completely elucidated, current concepts attribute an important role to a complex interplay between the gastrointestinal (GI) system and the central nervous system (CNS) [2][3][4]. IBS is commonly recognized as a brain-gut disorder, and psychosocial stress is its most widely acknowledged risk factor [5][6][7]. Through this brain-gut connection, we may explain why stress and psychological factors are linked so closely to gut function and dysfunction, as well as gastrointestinal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Comparative proteomic analysis of the brain and colon in three rat models of irritable bowel syndrome

et al. 2020

View full text Add to dashboard Cite

Background: Irritable bowel syndrome (IBS) has been gradually recognized as a disorder of the brain-gut interaction, but the molecular changes in the brain and colon that occur in disease development remain poorly understood. We employed proteomic analysis to identify differentially expressed proteins in both the brain and colon of three IBS models. Methods: To explore the relevant protein abundance changes in the brain and colon, isobaric tags for relative and absolute quantitation (iTRAQ), liquid chromatography and tandem mass spectrometry (LC-MS) and Western blotting methods were used in three IBS models, including maternal separation (MS, group B), chronic wrap restraint stress (CWRS, group C) and a combination of MS and CWRS (group D). Results: We identified 153, 280, and 239 proteins that were common and differentially expressed in the two tissue types of groups B, C and D, respectively; 43 differentially expressed proteins showed the same expression changes among the three groups, including 25 proteins upregulated in the colon and downregulated in the brain, 7 proteins downregulated in the colon and upregulated in the brain, and 3 proteins upregulated and 8 downregulated in both tissues. Gene ontology analysis showed that the differentially expressed proteins were mainly associated with cellular assembly and organization and cellular function and maintenance. Protein interaction network and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that the differentiated proteins were mainly involved in the protein ubiquitination pathway and mitochondrial dysfunction. Conclusions: Taken together, the data presented represent a comprehensive and quantitative proteomic analysis of the brain and colon in IBS models, providing new evidence of an abnormal brain-gut interaction in IBS. These data may be useful for further investigation of potential targets in the diagnosis and treatment of IBS.

show abstract

Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome

O’Malley

2023

Visceral Pain

View full text Add to dashboard Cite

Emotional overactivity in patients with irritable bowel syndrome

Cited by 21 publications

References 59 publications

Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome

Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome

Comparative proteomic analysis of the brain and colon in three rat models of irritable bowel syndrome

Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome

Contact Info

Product

Resources

About