Emotional Memory in Early Steroid Abnormalities: An fMRI Study of Adolescents With Congenital Adrenal Hyperplasia

Mazzone, Luigi; Mueller, Sven C.; Maheu, Françoise S.; VanRyzin, Carol; Merke, Deborah P.; Ernst, Monique

doi:10.1080/87565641.2010.549866

Cited by 24 publications

(32 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cognitive and affective features are thought to place adolescents at an increased risk for engaging in behaviors with deleterious and dangerous consequences, such as tobacco and drug use, risky sexual activity, or reckless driving (Dahl, 2004; Eaton et al, 2006; Hingson, Heeren, Winter, & Wechsler, 2005; Spear, 2000; Steinberg, 2004, 2005). Inter-individual variability within this stereotypical description of the adolescent is large, and can be traced to hormonal changes (e.g., (Bramen et al, 2011; Forbes et al, 2010; Kuhn et al, 2010; Mazzone et al, 2011; Mueller, Ng, et al, 2010; Neufang et al, 2009; Oldehinkel, Verhulst, & Ormel, 2011), early life experience (Andersen & Teicher, 2009; Mueller, Maheu, et al, 2010; Pechtel & Pizzagalli, 2011; Suomi, 2006), genetic make-up (Cohen, 2010; Enoch, 2011; Schwandt et al, 2010), among many other factors. A better understanding of the underlying factors contributing to interindividual variability can be tremendously helpful for identifying targets for future primary and secondary treatment of untoward outcomes related to adolescent behavior.…”

Section: Adolescent Motivated Behavior and Brain Developmentmentioning

confidence: 99%

The triadic model perspective for the study of adolescent motivated behavior

Ernst

2014

Brain and Cognition

Self Cite

208

168

View full text Add to dashboard Cite

The triadic neural systems model is a heuristic tool, which was developed with the goal of providing a framework for neuroscience research into motivated behaviors. Unlike dual models that highlight dynamics between approach systems centered on striatal function and control systems centered on prefrontal cortex, the triadic model also includes an avoidance system, centered on amygdala-related circuits. A first application of this model has been to account for adolescent behavior.

show abstract

Section: Adolescent Motivated Behavior and Brain Developmentmentioning

confidence: 99%

The triadic model perspective for the study of adolescent motivated behavior

Ernst

2014

Brain and Cognition

Self Cite

208

168

View full text Add to dashboard Cite

show abstract

“…Neurological outcomes have not been systematically reported in these children, but a mild reduction in cognitive capacities and memory has been described in some, likely due to the effects of supraphysiological doses of corticosteroid replacement on the amygdala and hippocampus development [59, 60]. …”

Section: Adrenal Insufficiency and The Paediatric Brainmentioning

confidence: 99%

Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications

Salpietro

Polizzi

Rosa

et al. 2014

International Journal of Endocrinology

View full text Add to dashboard Cite

Various neurological and psychiatric manifestations have been recorded in children with adrenal disorders. Based on literature review and on personal case-studies and case-series we focused on the pathophysiological and clinical implications of glucocorticoid-related, mineralcorticoid-related, and catecholamine-related paediatric nervous system involvement. Childhood Cushing syndrome can be associated with long-lasting cognitive deficits and abnormal behaviour, even after resolution of the hypercortisolism. Exposure to excessive replacement of exogenous glucocorticoids in the paediatric age group (e.g., during treatments for adrenal insufficiency) has been reported with neurological and magnetic resonance imaging (MRI) abnormalities (e.g., delayed myelination and brain atrophy) due to potential corticosteroid-related myelin damage in the developing brain and the possible impairment of limbic system ontogenesis. Idiopathic intracranial hypertension (IIH), a disorder of unclear pathophysiology characterised by increased cerebrospinal fluid (CSF) pressure, has been described in children with hypercortisolism, adrenal insufficiency, and hyperaldosteronism, reflecting the potential underlying involvement of the adrenal-brain axis in the regulation of CSF pressure homeostasis. Arterial hypertension caused by paediatric adenomas or tumours of the adrenal cortex or medulla has been associated with various hypertension-related neurological manifestations. The development and maturation of the central nervous system (CNS) through childhood is tightly regulated by intrinsic, paracrine, endocrine, and external modulators, and perturbations in any of these factors, including those related to adrenal hormone imbalance, could result in consequences that affect the structure and function of the paediatric brain. Animal experiments and clinical studies demonstrated that the developing (i.e., paediatric) CNS seems to be particularly vulnerable to alterations induced by adrenal disorders and/or supraphysiological doses of corticosteroids. Physicians should be aware of potential neurological manifestations in children with adrenal dysfunction to achieve better prevention and timely diagnosis and treatment of these disorders. Further studies are needed to explore the potential neurological, cognitive, and psychiatric long-term consequences of high doses of prolonged corticosteroid administration in childhood.

show abstract

“…2007) or memory (Maheu et al . 2008; Mazzone et al . in press) processing of negative faces in patients with congenital adrenal hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with congenital adrenal hyperplasia (CAH), a disorder of both androgen excess and cortisol deficiency (Merke & Bornstein, 2005), exhibit impaired emotional memory, particularly for negative visual stimuli (Maheu et al . 2008) and show perturbed emotional face processing (Mazzone et al . in press).…”

Section: Introductionmentioning

confidence: 99%

Increased medial temporal lobe and striatal grey-matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study

Mueller¹,

Merke

Leschek

et al. 2010

Int. J. Neuropsychopharm.

Self Cite

View full text Add to dashboard Cite

Major questions remain about how sex hormones influence human brain development and cognition. Studies in humans and animals suggest a strong impact of androgen on the structure and function of the medial temporal lobe (MTL) and striatum. Using voxel-based morphometry (DARTEL), we compared MTL and striatal structures in 13 [mean age (±s.d.) 12.7 ± 3.2 yr, mean bone age 14.8 ± 3.2 yr] boys with familial male precocious puberty (FMPP), characterized by early excess androgen secretion, and 39 healthy age-matched boys (mean age 14.3 ± 2.5 yr). The FMPP group showed significantly larger grey-matter volume (GMV) in parahippocampal and fusiform gyri as well as putamen relative to controls. By comparison, larger GMV for controls relative to patients was only apparent in the precentral gyrus. Exploratory regression analyses that examined the impact of age on the current findings revealed a significant increase of GMV in the putamen with age in patients suffering from excess androgen but not in controls. Finally, current levels of free testosterone were obtained in the patient group. Analyses revealed a significant negative association indicating that FMPP boys with low levels of bioavailable testosterone exhibited high GMV in the bilateral striatum. The findings suggest a critical influence of androgen on human brain development and are discussed in relation to male-dominant psychiatric childhood disorders.

show abstract

Emotional Memory in Early Steroid Abnormalities: An fMRI Study of Adolescents With Congenital Adrenal Hyperplasia

Cited by 24 publications

References 91 publications

The triadic model perspective for the study of adolescent motivated behavior

The triadic model perspective for the study of adolescent motivated behavior

Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications

Increased medial temporal lobe and striatal grey-matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study

Contact Info

Product

Resources

About