Emotional Experience in Negative Symptoms of Schizophrenia—No Evidence for a Generalized Hedonic Deficit

Oorschot, Margreet; Lataster, Tineke; Thewissen, Viviane; Lardinois, M; Wichers, Marieke; Os, Jim van; Delespaul, Philippe; Myin-Germeys, Inez

doi:10.1093/schbul/sbr137

Cited by 149 publications

(162 citation statements)

References 35 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…Results from this study showed that patients have the capacity for normal hedonic reactions when they are experienced and measured in the moment, but reported anticipating less pleasure from future activities, specifically when the activities were goal directed, such as making dinner, doing an errand, working, or studying. Such dissociation of anticipatory motivation and hedonic reaction has also been shown using other approaches [9][10][11] and is supported by a recent extensive review. 12 Anticipatory pleasure is known to drive goal-directed behaviors aimed at achieving desired rewards.…”

Section: Patients Exhibit Deficits In Anticipatory Motivation Withoutsupporting

confidence: 66%

Schizophrenia in Translation: Dissecting Motivation in Schizophrenia and Rodents

Simpson

Waltz

Kellendonk

et al. 2012

Schizophrenia Bulletin

View full text Add to dashboard Cite

The negative symptoms of schizophrenia include deficits in motivation, for which there is currently no treatment available. animal models provide a powerful tool for identifying the potential pathophysiological mechanisms underlying the motivation deficits of schizophrenia with the aim of discovering novel treatment targets. The success of such an approach critically depends on meticulously detailed analysis of motivational phenotypes in patients and in animal models. here, we review the results of recent human behavioral and imaging studies of motivation, and we relate those findings to the results from animal studies, including a mouse model of striatal dopamine D2 receptor hyperfunction. The motivational deficit in patients with schizophrenia is not due to an inability to experience pleasure in the moment as hedonic reaction appears intact in patients. instead, the motivation deficit represents a reduced capacity for anticipating future pleasure resulting from goal-directed action. The diminished anticipation appears to be a consequence of an inability to accurately represent the expected reward values of actions. a strikingly similar phenotype in incentive motivation has also been described in mice with striatal dopamine D2 receptor hyperfunction. These convergent findings identify potential pathophysiological mechanisms that underlie the deficit in anticipatory motivation, and importantly, the mouse model provides a tool for investigating novel treatment strategies, which we discuss here.Key words: negative symptoms/anhedonia/incentive motivation/animal models Apathy, amotivation, or avolition was described by both Kraeplin and Bleuler as a core feature of schizophrenia.

show abstract

Section: Patients Exhibit Deficits In Anticipatory Motivation Withoutsupporting

confidence: 66%

Schizophrenia in Translation: Dissecting Motivation in Schizophrenia and Rodents

Simpson

Waltz

Kellendonk

et al. 2012

Schizophrenia Bulletin

View full text Add to dashboard Cite

show abstract

“…26 Furthermore, it has been demonstrated that individuals with a psychotic disorder show increased reactivity to positive events happening to them. 27 Specifically, they reported increased positive affect when a pleasant event was happening, suggesting an overall increased sensitivity to the environment, either positive or negative.…”

Section: Ecological Interventionist Causal Models In Psychosis Putatimentioning

confidence: 99%

“…30,31,33 However, individuals with schizophrenia and high negative symptoms have been found to show a stronger preference for being alone when in company and more social withdrawal in daily life. 27 Similarly, there is evidence of a greater preference for solitude, increased time alone, and lower positive affect in the daily life of individuals with subclinical social anhedonia. 28 While experience sampling studies have reported fewer goal-directed activities in individuals with schizophrenia, findings on a diminished effort in pursuit of complex goals in daily life remain equivocal.…”

Section: Ecological Interventionist Causal Models In Psychosis Putatimentioning

confidence: 99%

“…[27][28][29][30][31][32][33] Findings from these studies suggest that, surprisingly, deficits in expression and blunted affect in individuals with psychotic disorder are not associated with a reduced intensity of emotional experience in daily life. 30,31,33 However, individuals with schizophrenia and high negative symptoms have been found to show a stronger preference for being alone when in company and more social withdrawal in daily life.…”

Section: Ecological Interventionist Causal Models In Psychosis Putatimentioning

confidence: 99%

See 1 more Smart Citation

Ecological Interventionist Causal Models in Psychosis: Targeting Psychological Mechanisms in Daily Life

Reininghaus

Depp

Myin-Germeys

2015

SCHBUL

Self Cite

View full text Add to dashboard Cite

Integrated models of psychotic disorders have posited a number of putative psychological mechanisms that may contribute to the development of psychotic symptoms, but it is only recently that a modest amount of experience sampling research has provided evidence on their role in daily life, outside the research laboratory. A number of methodological challenges remain in evaluating specificity of potential causal links between a given psychological mechanism and psychosis outcomes in a systematic fashion, capitalizing on longitudinal data to investigate temporal ordering. In this article, we argue for testing ecological interventionist causal models that draw on real world and real-time delivered, ecological momentary interventions for generating evidence on several causal criteria (association, time order, and direction/sole plausibility) under real-world conditions, while maximizing generalizability to social contexts and experiences in heterogeneous populations. Specifically, this approach tests whether ecological momentary interventions can (1) modify a putative mechanism and (2) produce changes in the mechanism that lead to sustainable changes in intended psychosis outcomes in individuals' daily lives. Future research using this approach will provide translational evidence on the active ingredients of mobile health and in-person interventions that promote sustained effectiveness of ecological momentary interventions and, thereby, contribute to ongoing efforts that seek to enhance effectiveness of psychological interventions under real-world conditions.

show abstract

“…Negative beliefs about future performance in a particular activity (or defeatist performance beliefs) are thought to result from past experiences of failure (Rector et al, 2005;Rector, 2004;Grant and Beck, 2009;Horan et al, 2010;Avery et al, 2009). Low expectancy of pleasure is considered to arise through difficulties with anticipatory pleasure (predicting and pre-experiencing future pleasure), which is both impaired relative to non-clinical controls, and associated with ANS (Gard et al, 2007;Oorschot et al, 2013). We have summarised this body of research in a single anticipatory deficit model of ANS (Figure 1).…”

Section: Psychological Models Of Negative Symptoms In Psychosismentioning

confidence: 99%

Understanding and treating amotivation in people with psychosis: An experimental study of the role of guided imagery

Cox

Jolley

Johns

2016

Psychiatry Research

View full text Add to dashboard Cite

show abstract

Emotional Experience in Negative Symptoms of Schizophrenia—No Evidence for a Generalized Hedonic Deficit

Abstract: This study revealed no evidence for a generalized hedonic deficit in patients with psychotic spectrum disorders. Lower rather than higher levels of negative symptoms were associated with a pattern of emotional processing which was different from healthy controls.

Cited by 149 publications

References 35 publications

Schizophrenia in Translation: Dissecting Motivation in Schizophrenia and Rodents

Schizophrenia in Translation: Dissecting Motivation in Schizophrenia and Rodents

Ecological Interventionist Causal Models in Psychosis: Targeting Psychological Mechanisms in Daily Life

Understanding and treating amotivation in people with psychosis: An experimental study of the role of guided imagery

Contact Info

Product

Resources

About