Emotional dysfunctions in neurodegenerative diseases

Löffler, Leonie; Radke, Sina; Morawetz, Carmen; Derntl, Birgit

doi:10.1002/cne.23816

Cited by 28 publications

(28 citation statements)

References 107 publications

(134 reference statements)

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“…For example, structural and functional deficits in the insula have been implicated in anxiety disorders [43, 44], in schizophrenia for disturbed affective processing [45], in psychopathy for abnormal social emotion processing such as empathetic pain processing [46], and in anorexia nervosa for distorted subjective feelings of one’s body [47]. Insula pathology has also been implicated in neurological disorders, including Huntington’s disease and multiple sclerosis for impaired processing of facial emotions [48], and Alzheimer’s disease for the loss of sense of self [49]. …”

Section: Pathological Roles Of the Insula In Psychiatric And Neurologmentioning

confidence: 99%

The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology

Namkung

Kim

Sawa

2017

Trends in Neurosciences

303

226

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Supported by recent human neuroimaging studies, the insula is re-emerging as an important brain area not only in the physiological understanding of the brain, but also in pathological contexts in clinical research. Here, we briefly introduce the anatomical and histological features of the human insula. We then summarize the physiological functions of the insula and underscore its pathological roles in psychiatric and neurological disorders that have long been underestimated. We finally propose possible strategies through which the role of the insula may be further understood for both basic and clinical neuroscience.

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Section: Pathological Roles Of the Insula In Psychiatric And Neurologmentioning

confidence: 99%

The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology

Namkung

Kim

Sawa

2017

Trends in Neurosciences

303

226

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“…Indeed, the cingulate cortex and amygdala are also known to be involved in the neurodegenerative process of PD (5–8). Therefore, a proportion of patients suffer from altered emotional processing (9, 10). …”

Section: Introductionmentioning

confidence: 99%

Altered Kinematics of Facial Emotion Expression and Emotion Recognition Deficits Are Unrelated in Parkinson’s Disease

et al. 2016

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BackgroundAltered emotional processing, including reduced emotion facial expression and defective emotion recognition, has been reported in patients with Parkinson’s disease (PD). However, few studies have objectively investigated facial expression abnormalities in PD using neurophysiological techniques. It is not known whether altered facial expression and recognition in PD are related.ObjectiveTo investigate possible deficits in facial emotion expression and emotion recognition and their relationship, if any, in patients with PD.MethodsEighteen patients with PD and 16 healthy controls were enrolled in this study. Facial expressions of emotion were recorded using a 3D optoelectronic system and analyzed using the facial action coding system. Possible deficits in emotion recognition were assessed using the Ekman test. Participants were assessed in one experimental session. Possible relationship between the kinematic variables of facial emotion expression, the Ekman test scores, and clinical and demographic data in patients were evaluated using the Spearman’s test and multiple regression analysis.ResultsThe facial expression of all six basic emotions had slower velocity and lower amplitude in patients in comparison to healthy controls (all Ps < 0.05). Patients also yielded worse Ekman global score and disgust, sadness, and fear sub-scores than healthy controls (all Ps < 0.001). Altered facial expression kinematics and emotion recognition deficits were unrelated in patients (all Ps > 0.05). Finally, no relationship emerged between kinematic variables of facial emotion expression, the Ekman test scores, and clinical and demographic data in patients (all Ps > 0.05).ConclusionThe results in this study provide further evidence of altered emotional processing in PD. The lack of any correlation between altered facial emotion expression kinematics and emotion recognition deficits in patients suggests that these abnormalities are mediated by separate pathophysiological mechanisms.

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“…For example, structural and functional deficits in the insula have been implicated in anxiety disorders [43,44], in schizophrenia for disturbed affective processing [45], in psychopathy for abnormal social emotion processing such as empathetic pain processing [46], and in anorexia nervosa for distorted subjective feelings of one's body [47]. Insula pathology has also been implicated in neurological disorders, including Huntington's disease and multiple sclerosis for impaired processing of facial emotions [48], and Alzheimer's disease for the loss of sense of self [49].…”

Section: Pathological Roles Of the Insula In Psychiatric And Neurologmentioning

confidence: 99%

The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology

Namkung¹,

Kim²,

Sawa³

2018

Trends in Neurosciences

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show abstract

Emotional dysfunctions in neurodegenerative diseases

Cited by 28 publications

References 107 publications

The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology

The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology

Altered Kinematics of Facial Emotion Expression and Emotion Recognition Deficits Are Unrelated in Parkinson’s Disease

The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology

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