Emollient efficacy and acceptability in the treatment of eczematous dry skin: A double-blind, randomised comparison of two UK-marketed products

Abstract

Objective: The aim of this study was to compare the moisturising efficacy and acceptability of physical characteristics of two commonly prescribed emollients licenced in the UK, Doublebase Dayleve gel (DELP) and Diprobase cream (DIPC). Methods: The study was a double-blind, concurrent bi-lateral comparison in female eczema subjects with dry skin. Results: In Part 1, comparing the area under the curve (AUC) change from baseline corneometer readings over 24 h following single applications of the emollients to the volar forearms of 34 subjects, the AUC for DELP was more than three times that seen for DIPC (p < 0.0001). In Part 2, comparing the same outcome measured over 5 days of twice daily applications to the lower legs in 36 subjects, the AUC for DELP was approximately five times that for DIPC (p < 0.0001). 69% of subjects “Like Slightly” or “Like Strongly” DELP compared to 33% for DIPC (p = 0.025). 72% indicated they would use DELP again compared to 33% for DIPC (p = 0.033). 75% of subjects preferred DELP, 17% preferred DIPC and 8% expressed no preference (p = 0.0004).

Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial

“…However, some research suggests that emollients that are ostensibly identical in their major constituents can still be experienced as different by the user. [19][20][21] Also, it cannot be assumed that the findings apply to non-study emollients. Missing electronic medical record data and the pragmatic nature of our design, in which the prescription was issued via the participant's general practitioner and usual pharmacy, meant that we were unable to confirm for some participants (29 [5%]) which emollients they initially received, and that nine (2%) participants received an emollient of the correct type but that was not study approved.…”

A real-world, non-interventional Indian study on clinical assessment of intense moisturizing formulation in dry skin disorders

“…In recent years, moisturizers account for the largest and important skin care product categories and are found to be beneficial in the management of dry skin associated with AD, psoriasis and ichthyosis. 3,4 Multiple guidelines recommend to apply moisturizer generously and frequently in order to maintain the hydration within the stratum corneum, thereby keeping the corneocytes "fluffed up" and closing the cracks leading to restoration of natural barrier function of the skin. 9 In our study, we evaluated real world effectiveness of MaxRich®; an intense moisturizer in the management of dry skin disorders like AD, psoriasis and ichthyosis.…”

“…In recent years, moisturizers account for the largest and important skin care product categories and are found to be beneficial in the management of dry skin associated with AD, psoriasis and ichthyosis. 3,4 The major function of moisturizers is to maintain the hydration within the stratum corneum and to overcome the skin dryness associated with certain diseases, they may be considered as therapeutic products. 5 There is abundance of moisturizers currently available in the market with different constituents and different claims.…”

A Double-Blind, Randomised Study Comparing the Skin Hydration and Acceptability of Two Emollient Products in Atopic Eczema Patients with Dry Skin

“…A sample size of 14 subjects was calculated to give 90% power to detect a difference in mean AUC of 524 between DELP and ZBC, using a 5% significance level. This difference in mean AUC was based on the results from a similar previous study [ 11 ]. Up to 20 subjects were therefore planned in order to allow for possible dropouts.…”