2019
DOI: 10.1016/j.phymed.2018.11.018
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Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle

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Cited by 28 publications
(20 citation statements)
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“…Secondly, emodin upregulates the levels of GLP-1R and PPAR- γ decreased in HFD mice in our experiment. However, emodin also protects individuals from weight gain, hyperglycemia, and hyperlipidemia in this work and others [ 43 , 44 ]. To exclude these potential mechanisms of beneficial effect from emodin, mice with hyperglycemia were removed from this experiment.…”
Section: Discussionsupporting
confidence: 62%
“…Secondly, emodin upregulates the levels of GLP-1R and PPAR- γ decreased in HFD mice in our experiment. However, emodin also protects individuals from weight gain, hyperglycemia, and hyperlipidemia in this work and others [ 43 , 44 ]. To exclude these potential mechanisms of beneficial effect from emodin, mice with hyperglycemia were removed from this experiment.…”
Section: Discussionsupporting
confidence: 62%
“…Let-7c, miR-20b, and miR-22 show relatively greater variance compared to others. Preliminary evidence supports associations between miR-20b and risk for T2DM, including insulin uptake in skeletal muscle [ 39 ] and T2DM-related complications including diabetic retinopathy [ 40 ] and endothelial cell function [ 41 ]. Similarly, miR-22 has been associated with adipose tissue mass, insulin sensitivity, and glucose homeostasis [ 42 ] and diabetic cardiomyopathy [ 43 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, miR-214 was further proved to be a regulator of DPP4 in the adipocytes. Accumulated evidence demonstrate that miRNAs could exist pivotal regulatory effects in the pathogenesis of various diseases mediated by the target genes [24][25][26][27]. In the disease progression of IR, some members of miRNAs with critical roles have also been reported [28].…”
Section: Discussionmentioning
confidence: 99%