Emodin attenuates high lipid-induced liver metastasis through the AKT and ERK pathways in vitro in breast cancer cells and in a mouse xenograft model

Li, Feng; Song, Xingguo; Zhou, Xiqiu; Chen, Lili; Zheng, Jinzhou

doi:10.1016/j.heliyon.2023.e17052

Cited by 3 publications

(1 citation statement)

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“…In addition, inhibition of cholesterol esterification, a feature of metastatic cancers using acyl-CoA: cholesterol acyltransferase inhibitors promotes ER stress-induced apoptosis in tumor cells ( Li et al, 2016 ). Natural product-derived medicines, such as emodin (an anthraquinone derivative), exert therapeutic effects on liver metastasis in HFD-induced obese and hyperlipidemic mice by inhibiting lipid synthesis ( Li et al, 2023a ).…”

Section: Therapeutic Exploitation Of Lipid Metabolism In Metastatic L...mentioning

confidence: 99%

Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD

Kim,

Hyun

2024

Molecules and Cells

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Section: Therapeutic Exploitation Of Lipid Metabolism In Metastatic L...mentioning

confidence: 99%

Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD

Kim,

Hyun

2024

Molecules and Cells

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Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases

Yu,

Zhao,

Zhao

2023

Front. Pharmacol.

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Rhubarb palmatum L., Polygonum multijiorum Thunb., and Polygonum cuspidatum Sieb. Et Zucc. are traditional Chinese medicines that have been used for thousands of years. They are formulated into various preparations and are widely used. Emodin is a traditional Chinese medicine monomer and the main active ingredient in Rhubarb palmatum L., Polygonum multijiorum Thunb., and Polygonum cuspidatum Sieb. Et Zucc. Modern research shows that it has a variety of pharmacological effects, including promoting lipid and glucose metabolism, osteogenesis, and anti-inflammatory and anti-autophagy effects. Research on the toxicity and pharmacokinetics of emodin can promote its clinical application. This review aims to provide a basis for further development and clinical research of emodin in the treatment of metabolic diseases. We performed a comprehensive summary of the pharmacology and molecular mechanisms of emodin in treating metabolic diseases by searching databases such as Web of Science, PubMed, ScienceDirect, and CNKI up to 2023. In addition, this review also analyzes the toxicity and pharmacokinetics of emodin. The results show that emodin mainly regulates AMPK, PPAR, and inflammation-related signaling pathways, and has a good therapeutic effect on obesity, hyperlipidemia, non-alcoholic fatty liver disease, diabetes and its complications, and osteoporosis. In addition, controlling toxic factors and improving bioavailability are of great significance for its clinical application.

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Therapeutic Potential of 1,8-Dihydroanthraquinone Derivatives for Breast Cancer

Okon,

Gaweł-Bęben,

Jarzab

et al. 2023

IJMS

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Breast cancer (BC) is the most common malignancy among women worldwide. In recent years, significant progress has been made in BC therapy. However, serious side effects resulting from the use of standard chemotherapeutic drugs, as well as the phenomenon of multidrug resistance (MDR), limit the effectiveness of approved therapies. Advanced research in the BC area is necessary to create more effective and safer forms of therapy to improve the outlook for individuals diagnosed with this aggressive neoplasm. For decades, plants and natural products with anticancer properties have been successfully utilized in treating various medical conditions. Anthraquinone derivatives are tricyclic secondary metabolites of natural origin that have been identified in plants, lichens, and fungi. They represent a few botanical families, e.g., Rhamnaceae, Rubiaceae, Fabaceae, Polygonaceae, and others. The review comprehensively covers and analyzes the most recent advances in the anticancer activity of 1,8-dihydroanthraquinone derivatives (emodin, aloe-emodin, hypericin, chrysophanol, rhein, and physcion) applied both individually, or in combination with other chemotherapeutic agents, in in vitro and in vivo BC models. The application of nanoparticles for in vitro and in vivo evidence in the context of 1,8-dihydroanthraquinone derivatives was also described.

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Emodin attenuates high lipid-induced liver metastasis through the AKT and ERK pathways in vitro in breast cancer cells and in a mouse xenograft model

Cited by 3 publications

References 37 publications

Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD

Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD

Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases

Therapeutic Potential of 1,8-Dihydroanthraquinone Derivatives for Breast Cancer

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