Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice

Luo, Shuang; Deng, Xiangliang; Liu, Qi; Pan, Zengfeng; Zhao, Zhongxiang; Zhou, Lian; Luo, Xia

doi:10.1016/j.intimp.2018.04.010

Cited by 42 publications

(27 citation statements)

References 25 publications

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“…It is reported that emodin (5, 10 and 20 mg/kg) treatment alleviates the symptoms and decreases the level of anti-flagellin in serum and suppresses the expressions of TLR5 and NF-κBp65 in colon of DSS-induced UC mice. Moreover, in vitro, emodin treatment inhibits the nuclear translocation of NF-κBp65 and decreases the release of IL-8 in flagellin-stimulated HT-29 cells via down-regulating the expressions of TLR5 and MyD88, up-regulating the expression of IκB [92]. Chrysophanol (5 mg/kg) treatment decreases the activation of NF-κBp65 and caspase-1 in DSS-treated colon tissue and LPS-stimulated murine peritoneal macrophages, which contributes to attenuation of overall clinical scores and various pathological markers of colitis via against inflammatory injury [93].…”

Section: Detoxificating and Purgative Medicinementioning

confidence: 93%

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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Nuclear factor-kappa B (NF-κB) is a kind of multi-functional nuclear transcription factor involved in regulating gene transcription to influence pathological evolution of inflammatory and immune diseases. Numerous literature evidence that NF-κB pathway plays an essential role in pathogenic development of ulcerative colitis (UC). UC is a chronic non-specific inflammatory bowel disease, and until now, therapeutic agents for UC including aminosalicylates, corticosteroids and immune inhibitors still cannot exert satisfied effects on patients. In recent years, Chinese medicines suggest the advantages of alleviating symptoms and signs, decreasing side-effects and recurrence, whose one of mechanisms is related to regulation of NF-κB pathway. In this review, we categorize Chinese medicines according to their traditional therapeutic functions, and summarize the characteristics of Chinese medicines targeting NF-κB pathway in UC treatment. It indicates that 85 kinds of Chinese medicines' compounds and formulae can directly act on NF-κBp65; while 58 Chinese medicines' ingredients and formulae indirectly suppress NF-κBp65 by regulation of its upstream or other related pathways. Moreover, by the analysis of Chinese medicines' category based on their traditional functions, we conclude the category of dampness-drying and detoxificating medicine targeting NF-κB pathway accounts for primary status for amelioration of UC. Simultaneously, this review also contributes to the choices of Chinese medicine category and provides curative potential of Chinese medicines for clinical UC treatment.

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Section: Detoxificating and Purgative Medicinementioning

confidence: 93%

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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“…Emodin downregulated the activation of NF-κB in a dose-dependent manner in SW1990 and PANC-1 cells (65,70,104). In flagellin-stimulated HT-29 cells, it was revealed that emodin downregulated the expression of toll-like receptor (TLR)5 and myeloid differentiation primary response 88 (MyD88), upregulated the expression of IκB, inhibited the nuclear translocation of NF-κB p65 and reduced the production of IL-8 (172). Pre-treatment of U87MG cells with emodin also significantly reduced NF-κB activation in a hyaluronic acid-induced cell invasion model in vitro (120).…”

Section: Inflammation and Immunomodulation [Tnf-α/nuclear Factor к-Light-chain-enhancer Of Activated B Cells (Nf-кb) Pathway]mentioning

confidence: 99%

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

2021

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Naturally occurring components from various species of Aloe have been used as traditional folk medicine since the ancient times. Over the last few decades, the therapeutic effects of extracts and phytochemical compounds obtained from Aloe vera have been proven in preclinical and clinical studies. Recently, compounds from other Aloe species apart from Aloe vera have been investigated for the treatment of different diseases, with a particular focus on cancer. In the present review, the effects of phytochemical compounds obtained from different Aloe species are discussed, with a specific focus on the effects on cell signalling in cancer and normal cells, and their selectivity and efficacy. This information will be useful for the application of Aloe-derived compounds as therapeutic agents, either alone or in combination with other standard drugs for cancer treatment. Contents 1. Introduction 2. Cell death initiation by the phytochemical compounds of Aloe 3. Anticancer selectivity 4. Cell cycle regulation 5. Cell signalling 6. Angiogenesis 7. Migration and invasion 8. Inflammation and immunomodulation (TNF-α/NF-κB pathway) 9. Recommendations for future applications 10. Conclusions

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“…Emodin was found to induce autophagy in L02 human hepatocytes by inhibiting PI3K/AKT/mTOR signaling pathway [29]. Emodin was found to protect mice from DSS-induced colitis via the regulation of TLR5/NF-κB signaling pathway [30], and significantly inhibit LPS-mediated NF-κB activation and DNA binding activity in RAW264.7 cells [31]. This is consistent with our computer-based research, and indicates that emodin can regulate PI3K-Akt signaling pathway to exert anti-inflammatory effects.…”

Section: Figure 7 Components-targets-pathways Network Of Caulis Sargentodoxaementioning

confidence: 99%

Revealing mechanism of Caulis Sargentodoxae for the treatment of ulcerative colitis based on network pharmacology approach

Liu

Zheng

et al. 2021

Bioscience Reports

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Objective: The traditional Chinese medicine Caulis Sargentodoxae is widely used in the treatment of ulcerative colitis (UC), but the mechanism remains unknown. The present study aims to reveal its effective components, targets and pathways through network pharmacology and bioinformatics approaches. Materials and methods: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was used to identify effective components. The ligand-based targets prediction was achieved through SwissTargetPrediction and TargetNet. UC-related targets were identified using Gene Expression Omnibus (GEO) data and DisGeNET. The common targets of disease and components were constructed and analyzed by PPI network. Lastly, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses are used to explain the functions of these common targets. Components-Targets-Pathways network was visualized and analyzed to further reveal the connection between the components and targets. Results: Eight active components and 102 key targets were identified to play an important role in UC. These targets were related to regulation of protein serine/threonine kinase activity, positive regulation of cell motility, response to molecule of bacterial origin, response to toxic substance, ERK1 and ERK2 cascade, peptidyl-tyrosine modification, inositol lipid-mediated signaling, cellular response to drug, regulation of inflammatory response and leukocyte migration. Moreover, HIF-1 signaling pathway and PI3K-Akt signaling pathway were the key targets involved in UC-related signaling pathways. Conclusion: The eight active components of Caulis Sargentodoxae mainly play a therapeutic role for UC through synergistic regulation of HIF-1 signaling pathway and PI3K-Akt signaling pathway.

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Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice

Cited by 42 publications

References 25 publications

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

Revealing mechanism of Caulis Sargentodoxae for the treatment of ulcerative colitis based on network pharmacology approach

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