Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization

Chen, Chujun; Lin, Zhenming; Liu, Wenbin; Hu, Qiong; Wang, Jie; Zhuang, Xinhua; Guan, Sujuan; Wu, Xiaoting; Hu, Tingting; Quan, Shijian; Jin, Xiaobao; Shen, Juan

doi:10.1016/j.ejphar.2022.175329

Cited by 27 publications

(8 citation statements)

References 43 publications

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“…This disruption results in the accumulation of M1-type macrophages within the wound, releasing pro-inflammatory cytokines that induce oxidative stress and cellular damage, thus prolonging the inflammatory phase [ 35 ]. Numerous studies have emphasized the significance of macrophage polarization in the healing of DFUs [ [36] , [35] , [37] ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of unilateral tibial cortex transverse transport on bilateral diabetic foot ulcers: A propensity score matching study

Qin,

Nie,

et al. 2023

Journal of Orthopaedic Translation

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of unilateral tibial cortex transverse transport on bilateral diabetic foot ulcers: A propensity score matching study

Qin,

Nie,

et al. 2023

Journal of Orthopaedic Translation

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“…PC is used in a TCM to clear heat and dampness, reduce yellowing and disperse stasis. 27 PC active components emodin can accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization while physcion can protects rats against cerebral ischemia-reperfusion injury; 28 , 29 Resveratrol and polydatin can both serve as modulators of calcium mobilization in the cardiovascular system, and emodin-8-O-β-D-glucoside promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells. 30 , 31 Modern pharmacology has also shown that the effects of PC include improving intestinal flora disorders and treating coronavirus infection.…”

Section: Discussionmentioning

confidence: 99%

Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway

Lan,

Zheng,

et al. 2023

DDDT

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Objective Traditional Chinese medicine Polygonum cuspidatum (PC) has significant effects on reducing pain. In this study, we investigated the analgesic effects of the alcohol extract of PC on three types of inflammatory pain and explored its mechanism. Methods Potential targets for the analgesic effects of the main active components of PC alcohol extract were screened by network pharmacology and molecular docking. Three different inflammatory pain mouse models (acetic acid twisting, formalin foot swelling, and xylene ear swelling) were used to study the analgesic effects of PC. The expression of latent signaling pathways in L 4-6 spinal cord tissues in formalin foot swelling mice was evaluated using real-time qPCR (RT-qPCR), Western blot (WB), and immunohistochemistry (IHC) analyses. Results Network pharmacology analysis shows that PC analgesic mechanism is related to the MAPK/ERK signaling pathway. The five main active components of PC have good docking ability with JNK and p38. PC alcohol extract significantly reduced the pain behavior and alleviated inflammatory reactions in three mouse models, inhibited the mRNA and protein phosphorylation levels of JNK, ERK, p38, and CREB in spinal cord tissues. Conclusion PC alcohol extract can inhibit inflammation and alleviate pain, which is related to its inhibition of the MAPK/ERK signaling pathway in spinal cord. Thus, PC alcohol extract is a promising candidate for pain treatment.

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“…M2 macrophages can be subdivided into M2a, M2b, M2c, and M2d. M2 macrophages have a low antigen-presenting ability and mostly release anti-inflammatory factors ( 39 ). IL-4 or IL-13 can effectively counteract inflammatory damage and promote tissue healing by stimulating macrophages to differentiate into M2a cells and release anti-inflammatory cytokines such as IL-1RA, IL-10, and transforming growth factor-beta (TGF-β) ( 40 , 41 ) via the co-receptor IL-4Rα.…”

Section: Macrophage Polarizationmentioning

confidence: 99%

Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives

Wang,

et al. 2024

Front. Immunol.

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Extracellular vesicles (EVs) are important cell-to-cell communication mediators. This paper focuses on the regulatory role of tumor-derived EVs on macrophages. It aims to investigate the causes of tumor progression and therapeutic directions. Tumor-derived EVs can cause macrophages to shift to M1 or M2 phenotypes. This indicates they can alter the M1/M2 cell ratio and have pro-tumor and anti-inflammatory effects. This paper discusses several key points: first, the factors that stimulate macrophage polarization and the cytokines released as a result; second, an overview of EVs and the methods used to isolate them; third, how EVs from various cancer cell sources, such as hepatocellular carcinoma, colorectal carcinoma, lung carcinoma, breast carcinoma, and glioblastoma cell sources carcinoma, promote tumor development by inducing M2 polarization in macrophages; and fourth, how EVs from breast carcinoma, pancreatic carcinoma, lungs carcinoma, and glioblastoma cell sources carcinoma also contribute to tumor development by promoting M2 polarization in macrophages. Modified or sourced EVs from breast, pancreatic, and colorectal cancer can repolarize M2 to M1 macrophages. This exhibits anti-tumor activities and offers novel approaches for tumor treatment. Therefore, we discovered that macrophage polarization to either M1 or M2 phenotypes can regulate tumor development. This is based on the description of altering macrophage phenotypes by vesicle contents.

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Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization

Cited by 27 publications

References 43 publications

Efficacy and safety of unilateral tibial cortex transverse transport on bilateral diabetic foot ulcers: A propensity score matching study

Efficacy and safety of unilateral tibial cortex transverse transport on bilateral diabetic foot ulcers: A propensity score matching study

Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway

Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives

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